[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332987-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332987-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-crosstalk-between-non-coding-rnas-and-oxidative-stress-in-cancer-progression","The crosstalk between non-coding RNAs and oxidative stress in cancer progression","","Cancer incidence among younger populations is rising, while conventional chemotherapy and drug responses are weakened by cancer-genome instability relative to more targeted treatments. Non-coding RNAs (ncRNAs) help shape genetic networks governing cancer growth and invasion by influencing mRNA production or protein binding. The review highlights that the bidirectional interaction between ncRNAs and oxidative stress—driven by harmful radicals—directly connects to cancer gene expression and signaling, offering mechanistic insight for identifying new cancer treatment strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-crosstalk-between-non-coding-rnas-and-oxidative-stress-in-cancer-progression/332987/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-crosstalk-between-non-coding-rnas-and-oxidative-stress-in-cancer-progression/332987.png","ImageObject",300,407,{"name":42,"@type":43},"Valentina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How do non-coding RNAs influence cancer-related genetic networks?","Question",{"text":63,"@type":64},"They shape genetic networks involved in cancer cell growth and invasion by affecting messenger RNA production or protein binding. They also regulate multiple cellular processes in cancer cells and the tumor microenvironment.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is oxidative stress in the context of cancer progression?",{"text":68,"@type":64},"Oxidative stress is characterized by excessive reactive oxygen species (ROS) that overwhelm antioxidant defenses, disrupting cellular redox balance. ROS correlate with carcinogenesis and malignant tumor progression.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is the ncRNA–oxidative stress crosstalk considered important for therapy development?",{"text":72,"@type":64},"Because oxidative stress impacts cancer gene expression and signaling, and ncRNAs respond to oxidative stress and in turn regulate downstream biological processes. Understanding this mechanism supports discovering new cancer treatment strategies.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332987,1790143642,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","+ MODEL  \nGenes & Diseases (2025) 12, 101286  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \nScienceDirect  \njournal [homepage:](homepage: www. keaipublishing. com/en/journals/genes-diseases)[ www. keaipublishing. com/en/journals/genes-diseases](homepage: www. keaipublishing. com/en/journals/genes-diseases)  \nREVIEW ARTICLE  \nThe crosstalk between non-coding RNAsand oxidative stress in cancer progression  \nQiqi Sun, Xiaoyong Lei* , Xiaoyan Yang **  \nSchool of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China  \nReceived 11 September 2023; received in revised form 7 February 2024; accepted 21 February 2024 Available online 10 April 2024  \nKEYWORDSAngiogenesis; Autophagy; Cancer;  \nCancer energy metabolism; Epithelial mesenchymal transformation; Non-coding RNAs; Oxidative stress  \nAbstract As living standards elevate, cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing years. One of the reasons is that instability in the cancer genome reduces the effectiveness of conventional drug treatments and chemotherapy, compared with more targeted therapies. Previous research has discovered non-coding RNAs’ crucial role in shaping genetic networks involved in cancer cell growth and invasion through their influence on messenger RNA production or protein binding. Additionally, the interaction between non-coding RNAs and oxidative stress, a crucial process in cancer advancement, cannot be overlooked. Essentially, oxidative stress results from the negative effects of radicals within the body and ties directly to cancer gene expression and signaling. Therefore, this review focuses on the mechanism between non-coding RNAsand oxidative stress in cancer progression, which is conducive to finding new cancer treatment strategies.ª 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. , Ltd. This is an open access article under the CC BY license ( [http://creativecommons.org/](http://creativecommons.org/)[ ](http://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/) ) .  \nIntroduction  \nWith the advancement of medical technology, cancer mortality keeps dropping, but on account of its highly heterogeneous nature, combating cancer remains challenging. According to Hanahan et al, cancer cells share several key properties, including the ability to evade growth suppressors, resist cell death, proliferate  \ncontinuously and replicate immortality, and exhibit genomic instability. Additionally, they regulate cellular energy, suppress immune disruption, induce angiogenesis, activate invasion and metastasis, and promote tumorrelated inflammation1 (Fig. 1) .  \nNon-coding RNAs (ncRNAs) constitute a class of RNAs that do not encode proteins, comprising approximately 98% of all RNAs.2 They are categorized into three main groups:  \n* Corresponding author.  \n** Corresponding author.  \nE-mail addresses: [1622214323@qq.com](1622214323@qq.com) (X. Lei), [yyangxiaoyan@163.com](yyangxiaoyan@163.com) (X. Yang).  \nPeer review under responsibility of Chongqing Medical University.  \n[https://doi.org/10.1016/j.gendis.2024.101286](https://doi.org/10.1016/j.gendis.2024.101286)  \n2352-3042/ª 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)).  \nFigure 1 Non-coding RNAs and oxidative stress work together in various stages of cancer progression, including cancer cell growth and reproduction, cancer cell invasion, tumor microenvironment shaping, epithelial interstitial conversion, energy metabolism, and angiogenesis.  \nmicroRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs) . miRNAs, with an average length of 22 nucleotides, play fundamental roles in regu","cbCaieb6qzcySK5J","https://ap.wps.com/l/cbCaieb6qzcySK5J","pdf",2472661,22,"English","# Introduction\n## Hallmarks and challenges in cancer progression\n## Non-coding RNAs (ncRNAs): classes and functions\n# Oxidative stress and its regulation in cancer\n## Reactive oxygen species and redox imbalance\n## Signaling pathways and targeted exploitation\n# ncRNAs and oxidative stress interplay in cancer (review focus)","[{\"question\":\"How do non-coding RNAs influence cancer-related genetic networks?\",\"answer\":\"They shape genetic networks involved in cancer cell growth and invasion by affecting messenger RNA production or protein binding. They also regulate multiple cellular processes in cancer cells and the tumor microenvironment.\"},{\"question\":\"What is oxidative stress in the context of cancer progression?\",\"answer\":\"Oxidative stress is characterized by excessive reactive oxygen species (ROS) that overwhelm antioxidant defenses, disrupting cellular redox balance. ROS correlate with carcinogenesis and malignant tumor progression.\"},{\"question\":\"Why is the ncRNA–oxidative stress crosstalk considered important for therapy development?\",\"answer\":\"Because oxidative stress impacts cancer gene expression and signaling, and ncRNAs respond to oxidative stress and in turn regulate downstream biological processes. Understanding this mechanism supports discovering new cancer treatment strategies.\"}]","The crosstalk between non-coding RNAs and oxidative stress in cancer progression | PDF",1790000294,55]