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Circular RNAs (circRNAs), covalently closed endogenous RNAs, are increasingly recognized as regulators of glycolytic phenotypes. This review summarizes circRNA mechanisms linking glucose-metabolism to gastrointestinal cancer biology, including control of glycolysis enzymes, transporters, and key signaling pathways, and evaluates circRNAs as diagnostic and prognostic biomarkers and therapeutic targets.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-crosstalk-and-clinical-implications-of-circrnas-and-glucose-metabolism-in-gastrointestinal-cancers-review/383509/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-crosstalk-and-clinical-implications-of-circrnas-and-glucose-metabolism-in-gastrointestinal-cancers-review/383509.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role does aerobic glycolysis play in gastrointestinal cancer progression?","Question",{"text":113,"@type":114},"Aerobic glycolysis converts glucose to lactate even under sufficient oxygen, supporting ATP production and biosynthesis while promoting progression and immunosuppression.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do circRNAs influence glucose metabolism in gastrointestinal cancers?",{"text":118,"@type":114},"CircRNAs regulate glucose metabolism by modulating glycolysis-associated enzymes and transporters and by affecting pivotal signaling pathways.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are glucose-metabolism-associated circRNAs important clinically?",{"text":122,"@type":114},"They may serve as new diagnostic and prognostic biomarkers and as therapeutic targets for gastrointestinal cancers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},383509,1790493422,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cancers   \nReview  \nThe Crosstalk and Clinical Implications of CircRNAs and Glucose Metabolism in Gastrointestinal Cancers  \nXiaonuan Luo 1, Yin Peng 1, Xinmin Fan 1, Xiaoxun Xie 2, Zhe Jin 1 and Xiaojing Zhang 1, *  \nCitation: Luo, X.; Peng, Y.; Fan, X.; Xie, X.; Jin, Z.; Zhang, X. The Crosstalk and Clinical Implications of CircRNAs and Glucose Metabolism in Gastrointestinal Cancers. Cancers 2023, 15, 2229. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/cancers15082229](10.3390/cancers15082229)  \nAcademic Editors: Maria Cristina Sini and Grazia Palomba  \nReceived: 21 February 2023  \nRevised: 5 April 2023  \nAccepted: 6 April 2023  \nPublished: 10 April 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention and Regional Immunity and Diseases, Department of Pathology, Basic Medicine School, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China; [xiaonuanluo@126.com](xiaonuanluo@126.com) (X.L.)  \n2 Department of Histology and Embryology, School of Pre-Clinical Medicine, Guangxi Medical University, Nanning 530021, China  \n* Correspondence: [apple432801@szu.edu.cn](apple432801@szu.edu.cn); Tel.: +86-0755-86671904  \nSimple Summary: Glucose metabolism reprogramming is a hallmark of cancer. In tumor cells, the majority of glucose is converted to lactate despite the presence of sufficient oxygen and functional mitochondria, thereby contributing to cancer progression and immunosuppression. Circular RNAs are a type of endogenous single-stranded RNAs characterized by covalently circular structures. Recent studies have revealed that circular RNAs regulate glucose metabolism in various cancers. In this review, we discuss the molecular mechanisms by which circular RNAs regulate glucose metabolism in gastrointestinal cancers. Furthermore, we consider the potential of glucose-metabolismassociated circular RNAs as new biomarkers and therapeutic targets for gastrointestinal cancers.  \nAbstract: The majority of glucose in tumor cells is converted to lactate despite the presence of sufficient oxygen and functional mitochondria, a phenomenon known as the “Warburg effect” or “aerobic glycolysis”. Aerobic glycolysis supplies large amounts of ATP, raw material for macromolecule synthesis, and also lactate, thereby contributing to cancer progression and immunosuppression. Increased aerobic glycolysis has been identified as a key hallmark of cancer. Circular RNAs (circRNAs) are a type of endogenous single-stranded RNAs characterized by covalently circular structures. Accumulating evidence suggests that circRNAs influence the glycolytic phenotype of various cancers. In gastrointestinal (GI) cancers, circRNAs are related to glucose metabolism by regulating specific glycolysis-associated enzymes and transporters as well as some pivotal signaling pathways. Here, we provide a comprehensive review of glucose-metabolism-associated circRNAs in GI cancers. Furthermore, we also discuss the potential clinical prospects of glycolysis-associated circRNAs as diagnostic and prognostic biomarkers and therapeutic targets in GI cancers.  \nKeywords: circular RNAs; glucose metabolism; gastrointestinal cancers; biomarkers; therapeutic targets  \n1. Introduction  \nGastrointestinal (GI) cancers include gastric cancer (GC), hepatocellular carcinoma (HCC), colorectal cancer (CRC), esophageal cancer (EC) and pancreatic cancer (PC) [1] . GI cancers are among the most prevalent tumors worldwide, accounting for approximately 35.4% of all cancer-related deaths and about 26.3% of the global cancer incidence [2] . The primary treatment for GI cancers is the surg","cbCaidsuKsB1C99x","https://ap.wps.com/l/cbCaidsuKsB1C99x","pdf",2093739,21,"English","# Introduction\n# Glucose metabolism and the Warburg effect\n# CircRNAs and regulation of glycolysis\n# Clinical implications in gastrointestinal cancers\n## Diagnostic and prognostic biomarkers\n## Therapeutic targets","[{\"question\":\"What role does aerobic glycolysis play in gastrointestinal cancer progression?\",\"answer\":\"Aerobic glycolysis converts glucose to lactate even under sufficient oxygen, supporting ATP production and biosynthesis while promoting progression and immunosuppression.\"},{\"question\":\"How do circRNAs influence glucose metabolism in gastrointestinal cancers?\",\"answer\":\"CircRNAs regulate glucose metabolism by modulating glycolysis-associated enzymes and transporters and by affecting pivotal signaling pathways.\"},{\"question\":\"Why are glucose-metabolism-associated circRNAs important clinically?\",\"answer\":\"They may serve as new diagnostic and prognostic biomarkers and as therapeutic targets for gastrointestinal cancers.\"}]","The Crosstalk and Clinical Implications of CircRNAs and Glucose Metabolism in Gastrointestinal Cancers - Review | PDF",1790257415,53]