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Biopsies in 10 patients and immunohistochemistry in 7 evaluated tissue changes. Results showed significant pre- vs post-treatment improvements with reduced epidermal thickness, lymphocyte infiltration, and CD3/CD4/CD8/CD20/CD117 cells, with no adverse events reported.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-combination-of-mineral-salts-and-natural-antioxidants-agents-is-highly-effective-in-atopic-dermatitis/434294/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-combination-of-mineral-salts-and-natural-antioxidants-agents-is-highly-effective-in-atopic-dermatitis/434294.png","ImageObject",300,407,{"name":42,"@type":43},"WPS_1786070896","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the objective of the study on mineral salts and natural antioxidants?","Question",{"text":63,"@type":64},"To evaluate the efficacy of a treatment combining mineral salts and natural antioxidants agents for patients with intrinsic atopic dermatitis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was treatment efficacy measured in the patients with atopic dermatitis?",{"text":68,"@type":64},"Efficacy was assessed using EASI, SCORAD, BSA, and vIGA-AD, plus patient-reported POEM and DLQI, and the pruritus Numeric Rating Scale (NRS).",{"name":70,"@type":61,"acceptedAnswer":71},"What key biological and clinical changes were observed after treatment?",{"text":72,"@type":64},"Clinical and patient-reported measurements improved strongly, epidermal thickness decreased, and lymphocyte infiltration and CD3, CD4, CD8, CD20, and CD117 cells were reduced. 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A long-lasting cycle of itch-scratch roots results in substantial morbidities and discomfort. Treatment of patients with moderate to severe dermatitis is a challenge. To evaluate the efficacy of a treatment based on mineral salts and natural antioxidants agents inpatients with AD.\u003Cbr>Patients and Methods: In this prospective study, 34 patients with AD were treated for 14 days. Patients were evaluated before and after treatment. The effects were studied by the following clinical measurements: Eczema Area and Severity Index (EASI), Scoring Atopic Dermatitis (SCORAD), Body Surface Area (BSA), and Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD) . Patient-reported measurements were also assessed: Patient-Oriented Eczema Measure (POEM), Dermatology Life Quality Index (DLQI), and the pruritus Numeric Rating Scale (NRS) . Biopsies were performed in 10 patients and immunohistochemistry tests in 7 patients.\u003Cbr>Results: All clinical and patient-reported measurements showed a strong difference before and after treatment. The epidermis thickness was significantly reduced, as well as the lymphocyte infiltration and the reduction of CD3, CD4, CD8, CD20 and CD117 cells. No adverse events were observed.\u003Cbr>Conclusion: This study shows that the severity of intrinsic dermatitis was drastically reduced with the treatment of mineral salts and natural antioxidants agents. This topic treatment was very well tolerated without adverse events.\u003Cbr>Plain Language Summary:\u003Cbr>Atopic dermatitis is very frequent disease of the skin. The symptoms are itching and eczematous skin lesions. Patients suffering from atopic dermatitis can develop systemic infections, cardiovascular diseases and to some neuropsychiatric conditions, including depression, anxiety and hyperactivity disorders.\u003Cbr>The most widely used treatment so far are glucocorticoids, which have significant side effects.\u003Cbr>Based on the effects of Dead Sea Water and magnesium salts, we designed a formula with natural ingredients. We combined mineral salts and antioxidants agents.\u003Cbr>In our study, we included 34 patients with atopic dermatitis who used our compound for 14 days. All patients showed significant improvement in their skin, as can be seen in the photographs of the 33 patients shown. We have also performed biopsies before and after treatment, showing an important improvement in the skin.\u003Cbr>In short, we have developed a natural product that has no side effects that moisturizes the skin, cures itching, and has antioxidant activity.\u003Cbr>keywords: dermatitis, atopic, mineral salts, therapeutics, pruritus, scratching |\n| --- |\n| Introduction\u003Cbr>Atopic dermatitis (AD) is a chronic inflammatory skin disease with exclusive clinical manifestations depending on age groups, race, or ethnicity. It is an important public health problem with a prevalence of 10–20% in children and 1–3% in |\n\nReceived: 5 September 2025  \nAccepted: 18 December 2025  \nPublished: 31 December 2025  \nClinical, Cosmetic and Investigational Dermatology 2025:18 3695–3711 3695  \n© 2025 Yori et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at [https://www.dovepress.com/terms.php](https://ww","cbCaihKe1BXKhm0c","https://ap.wps.com/l/cbCaihKe1BXKhm0c","pdf",10533214,17,"English","# Objective\n# Patients and Methods\n# Results\n# Conclusion\n# Plain Language Summary\n# Introduction","[{\"question\":\"What was the objective of the study on mineral salts and natural antioxidants?\",\"answer\":\"To evaluate the efficacy of a treatment combining mineral salts and natural antioxidants agents for patients with intrinsic atopic dermatitis.\"},{\"question\":\"How was treatment efficacy measured in the patients with atopic dermatitis?\",\"answer\":\"Efficacy was assessed using EASI, SCORAD, BSA, and vIGA-AD, plus patient-reported POEM and DLQI, and the pruritus Numeric Rating Scale (NRS).\"},{\"question\":\"What key biological and clinical changes were observed after treatment?\",\"answer\":\"Clinical and patient-reported measurements improved strongly, epidermal thickness decreased, and lymphocyte infiltration and CD3, CD4, CD8, CD20, and CD117 cells were reduced. No adverse events were observed.\"}]","The Combination of Mineral Salts and Natural Antioxidants Agents Is Highly Effective in Atopic Dermatitis | PDF",1790668405,43]