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In a cohort of 473 patients, clinicopathological characteristics, recurrence patterns, prognosis, and genetic alterations were compared between early and late recurrence groups. Early recurrence showed larger tumors, more invasive features, advanced T/N/TNM stage and worse 5-year overall survival, with subtype-specific genetic distinctions. Multivariate analysis identified age, recurrence, and pathological N categories as independent prognostic factors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-clinicopathological-and-genetic-differences-among-gastric-cancer-patients-with-no-recurrence-early-recurrence-and-late-recurrence-after-curative-surgery/436873/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-clinicopathological-and-genetic-differences-among-gastric-cancer-patients-with-no-recurrence-early-recurrence-and-late-recurrence-after-curative-surgery/436873.png","ImageObject",300,407,{"name":92,"@type":93},"Putri","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were early and late recurrence defined after curative surgery?","Question",{"text":112,"@type":113},"Early recurrence was defined as recurrence occurring within 2 years, while late recurrence was defined as recurrence occurring at 2 years or later.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What clinicopathological differences were observed between early and late recurrence?",{"text":117,"@type":113},"Patients with early recurrence had larger tumors, fewer superficial-type tumors, more lymphovascular invasion, more advanced pathological T and N categories and TNM stages, and worse 5-year overall survival.",{"name":119,"@type":110,"acceptedAnswer":120},"Which genetic alterations were most associated with early versus late recurrence?",{"text":121,"@type":113},"For intestinal-type gastric cancer, patients with no recurrence had more Helicobacter pylori infection, while for diffuse-type cancer, PIK3CA amplification frequency was highest in early recurrence. ARID1A mutations were more common in patients with single-site recurrence.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436873,1790794551,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","J Chin MedAssoc  \nOriginal article  \nThe clinicopathological and genetic differences among gastric cancer patients with no recurrence, early recurrence, and late recurrence after curative surgery  \nMeng-Chao Chena,b, Hsuan-Yu Suc,d, Yen-Hao Sue,f,g,h, Kuo-Hung Huangc,d,i,*, Wen-Liang Fangc,d,i, Chii-Wann Lina, Ming-Huang Chend,j, Yee Chaod,j, Su-Shun Lod,k, Anna Fen-Yau Lid,l, Chew-Wun Wuc,d  \naDepartment of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ROC; bDepartment of Neurosurgery, China Medical University Hospital, Taipei Branch, Taipei, Taiwan, ROC; cDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; dSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; eDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; fDivision of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC; gDivision of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; hTMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan, ROC; iGastric Cancer Medical Center, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; jCenter of Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; kDepartment of Surgery, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan, ROC; lDepartment of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC  \nAbstract  \nBackground: To date, few reports have investigated the genetic alterations and clinicopathological features among gastric cancer (GC) patients with no tumor recurrence, early recurrence, and late recurrence following curative surgery.  \nMethods: A total of 473 GC patients undergoing curative surgery were included. The clinicopathological characteristics, patient prognosis, recurrence patterns, and genetic alterations were compared between GC patients with early recurrence and late recurrence.  \nResults: Among the 473 GC patients, 119 had early recurrence (\u003C2 years) and 45 had late recurrence (≥2 years) . Patients with early recurrence had tumor size larger than 5 cm, fewer superficial-type tumors, more lymphovascular invasion, more advanced pathological T and N categories and Tumor, Node, Metastasis (TNM) stages, and worse 5-year overall survival than patients with late recurrence and no recurrence. For intestinal-type GC, patients with no tumor recurrence had more Helicobacter pylori infection than patients with early recurrence and late recurrence; for diffuse-type GC patients, the frequency of PIK3CA amplification was the highest in early recurrence, followed by late recurrence and no recurrence. GC patients with single-site recurrence had more ARID1A mutations than those with multiple-site recurrence. Multivariate analysis demonstrated that age, tumor recurrence, and pathological N categories were independent prognostic factors.  \nConclusion: PIK3CA amplifications were more common in diffuse-type GC with early recurrence, whereas ARID1A mutations were more common in patients with single-site recurrence. Targeted therapy and immunotherapy might be helpful for these patients.  \nKeywords: ARID1A; Early recurrence; Gastric cancer; Genetic alteration; Late recurrence; PIK3CA amplification  \n* Address correspondence. Dr. Kuo-Hung Huang, Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail address: khhuang@vghtpe.gov.tw](ROC. E-mail address: khhuang@vghtpe.gov.tw) (K.-H. Huang). Author Contributions: Dr. Meng-Chao Chen and Dr. Hsuan-Yu Su contributed equally to this article.  \nConflicts of interest: Dr. Yee Chao, an editorial board member at Journal of the Chinese Medical Association, had no role i","cbCaij6PUrG0VkXj","https://ap.wps.com/l/cbCaij6PUrG0VkXj","pdf",612638,"English","# Introduction\n# Background\n# Methods\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"How were early and late recurrence defined after curative surgery?\",\"answer\":\"Early recurrence was defined as recurrence occurring within 2 years, while late recurrence was defined as recurrence occurring at 2 years or later.\"},{\"question\":\"What clinicopathological differences were observed between early and late recurrence?\",\"answer\":\"Patients with early recurrence had larger tumors, fewer superficial-type tumors, more lymphovascular invasion, more advanced pathological T and N categories and TNM stages, and worse 5-year overall survival.\"},{\"question\":\"Which genetic alterations were most associated with early versus late recurrence?\",\"answer\":\"For intestinal-type gastric cancer, patients with no recurrence had more Helicobacter pylori infection, while for diffuse-type cancer, PIK3CA amplification frequency was highest in early recurrence. ARID1A mutations were more common in patients with single-site recurrence.\"}]","The clinicopathological and genetic differences among gastric cancer patients with no recurrence, early recurrence, and late recurrence after curative surgery | PDF",1790679310]