[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-326655-105":3,"detail-sidebar-cat-0-en-105":85,"doc-detail-326655-en":134},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":78,"head_meta":80,"extra_data":82,"updated_unix":84},105,"en","the-clinical-effectiveness-of-one-dose-vaccination-with-an-hpv-vaccine-a-metaanalysis-of-902368-vaccinated-women","The clinical effectiveness of one-dose vaccination with an HPV vaccine - A metaanalysis of 902368 vaccinated women","","The analysis evaluates whether a single-dose HPV vaccination achieves clinical effectiveness comparable to standard two- or three-dose regimens amid real-world constraints on adherence and budgets. A systematic review and meta-analysis compare outcomes including prevention of HPV16, HPV18, and hrHPV infections, as well as reductions in HSIL/ASC-H and CIN2/3 incidence. Results indicate immunogenic protection for at least 8 years alongside lower infection and precancerous events. Further long-term research is recommended to confirm robust evidence for vaccination strategy decisions.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-clinical-effectiveness-of-one-dose-vaccination-with-an-hpv-vaccine-a-metaanalysis-of-902368-vaccinated-women/326655/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-clinical-effectiveness-of-one-dose-vaccination-with-an-hpv-vaccine-a-metaanalysis-of-902368-vaccinated-women/326655.png","ImageObject",300,407,{"name":42,"@type":43},"Jiven","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the study address about HPV vaccination dosing?","Question",{"text":63,"@type":64},"The study examines the comparative effectiveness of one-dose HPV vaccination versus two- and three-dose regimens.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which clinical outcomes are analyzed in the meta-analysis?",{"text":68,"@type":64},"It assesses prevention of HPV16, HPV18, and hrHPV infections, incidence of HSIL or ASC-H, and incidence of CIN2/3.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the study conclude about the effectiveness of a single-dose HPV vaccine?",{"text":72,"@type":64},"The results suggest a single-dose schedule may be as effective as two- or three-dose schedules, supported by immunogenic protection for at least 8 years and reductions in infections and precancerous occurrences.",{"name":74,"@type":61,"acceptedAnswer":75},"What further evidence does the study call for?",{"text":76,"@type":64},"It recommends additional research and longer follow-up durations to establish stronger evidence for vaccination strategy recommendations.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},326655,1790170697,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,115,119,124,127,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},7,"Healthcare",40,"healthcare",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":117,"slug":118},8,30,"research-report",{"id":120,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":122,"slug":123},9,"Religion & Spirituality",20,"religion-spirituality",{"id":122,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":122,"slug":126},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":101,"slug":133},19,"General","general",{"code":4,"msg":86,"data":135},{"doc_id":83,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":116,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":143,"language":144,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":12,"update_tm":148,"read_time":149,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","PLOS ONE  \nOPEN ACCESS  \nCitation: Setiawan D, Nurulita NA, Khoirunnisa SM, Postma MJ (2024) The clinical effectiveness of one-dose vaccination with an HPV vaccine: A metaanalysis of 902,368 vaccinated women. PLoS ONE 19(1): e0290808 . [https://doi.org/10.1371/journal](https://doi.org/10.1371/journal). pone.0290808  \nEditor: Gregory Halle-Ekane, University of Buea, CAMEROON  \nReceived: August 14, 2023  \nAccepted: November 7, 2023  \nPublished: January 5, 2024  \nPeer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here:  \n[https://doi.org/10.1371/journal.pone.0290808](https://doi.org/10.1371/journal.pone.0290808)  \n[Copyright:](Copyright:) © [2024 Setiawan](2024 Setiawan) et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: All relevant data are within the paper and its Supporting Information files.  \nRESEARCH ARTICLE  \nThe clinical effectiveness of one-dose vaccination with an HPV vaccine: A metaanalysis of 902,368 vaccinated women  \nDidik Setiawan1,2 *, Nunuk Aries Nurulita1, Sudewi Mukaromah Khoirunnisa3,4, Maarten J. Postma3,5,6  \n1 Faculty of Pharmacy, University of Muhammadiyah Purwokerto, Purwokerto, Indonesia, 2 Center for Health Economic Studies, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia, 3 Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, 4 Department of Pharmacy, Institute Teknologi Sumatera, Lampung Selatan, Indonesia, 5 Unit of Pharmaco-Therapy, Epidemiology & Economics (PTE2), Department of Pharmacy, University of Groningen, Groningen, The Netherlands, 6 Department of Economics, Econometrics & Finance, Faculty of Economics & Business, University of Groningen, Groningen, The Netherlands  \n* [d.didiksetiawan@gmail.com](d.didiksetiawan@gmail.com)  \nAbstract  \nBackground  \nThe comprehensive effectiveness of the HPV vaccine has been widely acknowledged. However, challenges such as dosing adherence and limited budgets have led to delays in HPV vaccination implementation in many countries. A potential solution to these issues could lie in a one-dose vaccination with an HPV vaccine, as indicated by promising outcomes in multiple studies.  \nMethods  \nIn this systematic review and meta-analysis, we examine the comparative effectiveness of the one-dose vaccination with an HPV vaccine against two-and three-dose regimens. Our investigation focuses on clinical efficacy, encompassing the prevention of HPV16, HPV18, and hrHPV infections, HSIL or ASC-H incidence, and CIN2/3 incidence.  \nResults  \nOur analysis suggests that a single-dose HPV vaccine may offer effectiveness on par with two-or three-dose schedules. This conclusion is drawn from its capacity to confer immunogenic protection for at least 8 years of follow-up, coupled with its ability to mitigate infections and pre-cancerous occurrences.  \nConclusion  \nWhile our findings underscore the potential of the one-dose vaccination with an HPV vaccine, further research and prolonged study durations are necessary to establish robust evidence supporting this recommendation. As such, continued investigation will be critical for informing vaccination strategies  \nFunding: These findings are the result of work supported by Universitas Muhammadiyah Purwokerto. Indonesia. The views expressed in this paper are those of the authors, and no official endorsement by Universitas Muhammadiyah Purwokerto is intended or should be inferred. NAN and MJP received no financial compensation for their contributions to this work. The funders had no role in study design, data coll","cbCaifSOiZ0FOwzM","https://ap.wps.com/l/cbCaifSOiZ0FOwzM","pdf",2710982,18,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Cervical cancer and HPV burden\n## Prevention strategies and vaccines","[{\"question\":\"What question does the study address about HPV vaccination dosing?\",\"answer\":\"The study examines the comparative effectiveness of one-dose HPV vaccination versus two- and three-dose regimens.\"},{\"question\":\"Which clinical outcomes are analyzed in the meta-analysis?\",\"answer\":\"It assesses prevention of HPV16, HPV18, and hrHPV infections, incidence of HSIL or ASC-H, and incidence of CIN2/3.\"},{\"question\":\"What does the study conclude about the effectiveness of a single-dose HPV vaccine?\",\"answer\":\"The results suggest a single-dose schedule may be as effective as two- or three-dose schedules, supported by immunogenic protection for at least 8 years and reductions in infections and precancerous occurrences.\"},{\"question\":\"What further evidence does the study call for?\",\"answer\":\"It recommends additional research and longer follow-up durations to establish stronger evidence for vaccination strategy recommendations.\"}]","The clinical effectiveness of one-dose vaccination with an HPV vaccine - A metaanalysis of 902368 vaccinated women | PDF",1789975007,45]