[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-337992-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-337992-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-cervical-cancer-related-distribution-coinfection-and-risk-of-15-hpv-types-in-baoan-shenzhen-in-20172023-abstract","The cervical cancer related distribution, coinfection and risk of 15 HPV types in Baoan, Shenzhen, in 2017–2023 - Abstract","","Cervical cancer is a major malignant tumor, driven primarily by human papillomavirus (HPV) infection, making screening and early treatment central to prevention. To support region-specific screening strategies, records of HPV genotyping, TCT, and colposcopy with biopsy were retrospectively collected for 63,906 women screened at Shenzhen Baoan Shiyan People’s Hospital and affiliated institutions from 2017.01 to 2023.05. Colposcopy identified 814 high-grade CIN among 10,238 examinations; among 763 high-grade CIN with both TCT and HPV results, most cytology-normal cases remained HPV-positive. High-grade CIN rates in coinfections were lower than predicted single-infection rates, and HPV 52, 58, and 16 were most common, suggesting HPV coinfection does not increase cervical cancer risk.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-cervical-cancer-related-distribution-coinfection-and-risk-of-15-hpv-types-in-baoan-shenzhen-in-20172023-abstract/337992/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-cervical-cancer-related-distribution-coinfection-and-risk-of-15-hpv-types-in-baoan-shenzhen-in-20172023-abstract/337992.png","ImageObject",300,407,{"name":42,"@type":43},"Liam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What data sources were used to evaluate cervical cancer risk in Baoan, Shenzhen from 2017 to 2023?","Question",{"text":63,"@type":64},"Screening records included HPV genotyping results, TCT results, and colposcopy inspections with biopsy from Shenzhen Baoan Shiyan People’s Hospital and related community health centers between 2017.01 and 2023.05.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which HPV types were reported as the most common in Baoan, Shenzhen?",{"text":68,"@type":64},"HPV 52, 58, and 16 were identified as the most common HPV types in Baoan, Shenzhen.",{"name":70,"@type":61,"acceptedAnswer":71},"Do HPV coinfections increase the risk of cervical cancer based on the reported findings?",{"text":72,"@type":64},"The results suggested that HPV coinfections should not increase the risk for cervical cancers, with high-grade CIN rates in coinfections lower than estimated rates from related single infections.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},337992,1790094158,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Li et al. Virology Journal (2024) 21:164 [https://doi.org/10.1186/s12985-024-02439-2](https://doi.org/10.1186/s12985-024-02439-2)  \nVirology Journal  \nRESEARCH Open Access  \nThe cervical cancer related distribution,   coinfection and risk of 15 HPV types in Baoan, Shenzhen, in 2017–2023  \nRukai Li 1*, Weiwei Meng 1, Yunhai Zuo 1, Yanli Xu 1 and Shaonan Wu 1  \nAbstract  \nCervical cancer is one of the most common malignant tumours. Human papillomavirus (HPV) infection is the main cause of this cancer so that it could be prevented by screening and early treatment. Developing reginal screen protocols of maximum public health efficacy requires in-depth understandings of local HPV distribution and consequential cancer risks. Therefore, test results of HPV genotyping, cytology testing (TCT) and col poscopy inspection with biopsy were collected in this retrospective research. Data included by this research involved 63,906 women received screen related tests from Shenzhen Baoan Shiyan People’s Hospital and the subsidiary institutes between 2017.01 and 2023.05. 10,238 col poscopies were performed in this period collecting 8,716 samples and 814 high-grade CIN were discovered. Within the 763 high-grade CIN cases with both TCT and HPV testing results, 232 were tested cytologically normal but only 30 were negative in HPV test. Besides, the rates of high-grade CIN observed in coinfection were all lower than the estimated rates generated from related single infection. HPV 52, 58 and 16 were found to be the most common types in Baoan, Shenzhen. The result also suggested that HPV coinfections should not increase risk for cervical cancers.  \nKeywords HPV, TCT, Col poscopy, Cervical cancer, Coinfection  \nIntroduction  \nCervical cancer is the fourth most common female malignant tumour [1, 2] with more than 500,000 new cases worldwide causing about 250,000 death in China each year [3]. Standard screening procedure for cervical cancer includes ThinPrep cytologic tests (TCTs), human papillomavirus (HPV) infection test and colposcopy guided biopsy [4]. HPV infection is one of the most common sexually transmitted diseases and a primary cause of cervical cancer [5]. Based on carcinogenicity, subtypes  \n*Correspondence: Rukai Li [rkli2024@163.com](rkli2024@163.com)  \n1Shenzhen Baoan Shiyan People’s Hospital, No. 11 Jixiang Road, Shiyan, Baoan District, Shenzhen 518108, China  \nHPV can be divided into high-risk types, including 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59, and low-risk types such as 6, 11, 66, 73 and 82 [6]. Low-risk HPV types often cause warts not progressing into cancers.  \nCervical cancers are preventable through controlling HPV infections. HPV are mainly transmitted through skin-to-skin or skin-to-mucosa contact by targeting mucosal tissues, causing cancers in vulva, vagina, penis or anus [7]. Apart from cervical cancer screening, another effective measure to prevent cervical cancer is HPV vaccination [8]. By the time this article was written, there were 3 HPV vaccines available in the market, covering HPV types 16, 18 (bivalent) and 6, 11, 16, 18 (quadrivalent) and 6, 11, 16, 18, 31, 33, 45, 52, 58 (nonavalent) respectively. However, these vaccines were not included by national immunisation program due to high price and  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, y","cbCaidyriPFU5ksA","https://ap.wps.com/l/cbCaidyriPFU5ksA","pdf",1543582,"English","# Abstract\n# Introduction\n# Methodology\n## Patient enrolment criteria and screening protocol","[{\"question\":\"What data sources were used to evaluate cervical cancer risk in Baoan, Shenzhen from 2017 to 2023?\",\"answer\":\"Screening records included HPV genotyping results, TCT results, and colposcopy inspections with biopsy from Shenzhen Baoan Shiyan People’s Hospital and related community health centers between 2017.01 and 2023.05.\"},{\"question\":\"Which HPV types were reported as the most common in Baoan, Shenzhen?\",\"answer\":\"HPV 52, 58, and 16 were identified as the most common HPV types in Baoan, Shenzhen.\"},{\"question\":\"Do HPV coinfections increase the risk of cervical cancer based on the reported findings?\",\"answer\":\"The results suggested that HPV coinfections should not increase the risk for cervical cancers, with high-grade CIN rates in coinfections lower than estimated rates from related single infections.\"}]","The cervical cancer related distribution, coinfection and risk of 15 HPV types in Baoan, Shenzhen, in 2017–2023 - Abstract | PDF",1790021469]