[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-435956-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-435956-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-cerebellar-involvement-in-essential-tremor-the-connecting-roads","The cerebellar involvement in essential tremor: the connecting roads","","Essential tremor (ET) is the most prevalent movement disorder worldwide, affecting about 1% of the general population and up to 5% of people over 65. It presents as involuntary rhythmic oscillations, mainly postural and kinetic tremors in the upper limbs. Genetic, neuropathological, neurophysiological, and neuroimaging studies reveal functional, neurotransmitter-related, and structural abnormalities in the cerebello-thalamo-cortical circuit. Overall findings position ET as a neurodegenerative syndrome with diverse etiologies, while underscoring cerebellar involvement.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-cerebellar-involvement-in-essential-tremor-the-connecting-roads/435956/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-cerebellar-involvement-in-essential-tremor-the-connecting-roads/435956.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-07","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",16,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is essential tremor and who is commonly affected?","Question",{"text":63,"@type":64},"Essential tremor is a prevalent movement disorder marked by involuntary rhythmic oscillations, mainly postural and kinetic tremors in the upper limbs. It affects about 1% of the general population and about 5% of individuals over 65.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do current studies connect essential tremor to the cerebellum?",{"text":68,"@type":64},"The review links ET to cerebellar involvement through evidence from genetic, neuropathological, neurophysiological, and neuroimaging studies. Findings indicate abnormalities and altered connectivity within the cerebello-thalamo-cortical circuit.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the aim and scope of the narrative review?",{"text":72,"@type":64},"The review aims to synthesize findings across studies addressing ET pathophysiology, neuropathology, genetics, clinical features, neuroimaging, and treatment approaches, specifically emphasizing the cerebellum’s role in ET.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},435956,1790768250,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":113,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Article published online: 2025-10-27  \nReview Article 1  \nThe cerebellar involvement in essential tremor: the connecting roads  \nCarlos Henrique Ferreira Camargo 1 Léo Coutinho 1 Luís Eduardo B. M. Zubko2 Gustavo L. Franklin3,4 Hélio Afonso Ghizoni Teive 1,2  \n1 Universidade Federal do Paraná, Programa de Pós-Graduação em Medicina Interna, Disciplina de Doenças Neurodegenerativas, Curitiba PR, Brazil.  \n2 Universidade Federal do Paraná, Departamento de Clínica Médica, Serviço de Neurologia, Curitiba PR, Brazil.  \n3 Universidade Federal do Paraná, Departamento de Clínica Médica, Serviço de Clínica Médica, Curitiba PR, Brazil.  \n4 Pontifícia Universidade Católica do Paraná, Faculdade de Medicina, Departamento de Clínica Médica, Curitiba PR, Brazil.  \nArq. Neuro-Psiquiatr. 2025;83(10):s00451812324 .  \nAddress for correspondence Carlos Henrique Ferreira Camargo (email: [chcamargo@uol.com.br](chcamargo@uol.com.br))  \nAbstract  \nKeywords  \n► Essential Tremor  \n► Cerebellum  \n► Purkinje Cells  \n► Inferior Olivary Complex  \n► Cholinergic Antagonists  \nEssential tremor (ET) is the most prevalent movement disorder globally, affecting about 1% of the general population and 5% of those aged over 65 years. Characterized by involuntary, rhythmic oscillations, it primarily manifests as postural and kinetic tremors, predominantly in the upper limbs. Genetic studies, neuropathological examinations, neurophysiological assessments, and various neuroimaging techniques have demonstrated functional, neurotransmitter-related, and structural abnormalities within the cerebello-thalamo-cortical circuit. These findings collectively portray ET as aneurodegenerative syndrome with diverse etiologies and clinical manifestations, highlighting the involvement of the cerebellum.  \nINTRODUCTION  \nEssential tremor (ET) is the most prevalent movement disorder globally, affecting about 1% of the general population and 5% of those over 65.1 Characterized by involuntary, rhythmic oscillations, ET primarily manifests as postural and kinetic tremors, predominantly in the upper limbs, with a frequency ranging from 4 to 12Hz. While it traditionally affects the hands, in approximately 95% of the cases, other areas can also be involved, such as the head, tongue, legs, voice, face, chin, and torso.2  \nHistorically, ET was first differentiated from Parkinson’s disease (PD) by James Parkinson in 1817, a distinction  \nreceived April 9, 2025  \nreceived in its final form July 15, 2025  \naccepted July 27, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1812324 . ISSN 0004-282X.  \nEditor-in-Chief: Ayrton Roberto Massaro.  \nAssociate Editor: Orlando G. P. Barsottini.  \npublished posthumously in 1872 by Jean-Matin Charcot.3–5 The term essential tremor (initially from the Italian “tremoresemplice essenziale”) was coined by Pietro Burresi in 1874 and, over the years, the understanding of ET has evolved significantly.6 Once considered a monosymptomatic condition, recent studies have challenged this view, documenting additional motor signs and a range of nonmotor features, thus recognizing it as a complex neurodegenerative syndrome with diverse causes and manifestations.7,8  \nNeuroimaging and functional studies have played a crucial role in enhancing our understanding of ET, particularly highlighting the cerebellum’s involvement. These studies have demonstrated structural and functional abnormalities  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Revinter Publicações Ltda. , Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil  \n2 Cerebellum and essential tremor Camargo et al.  \nin this area, associated with altered connectivi","cbCaigmMuyZu8X1w","https://ap.wps.com/l/cbCaigmMuyZu8X1w","pdf",3039311,12,"English","# Abstract\n# Introduction\n# Methods","[{\"question\":\"What is essential tremor and who is commonly affected?\",\"answer\":\"Essential tremor is a prevalent movement disorder marked by involuntary rhythmic oscillations, mainly postural and kinetic tremors in the upper limbs. It affects about 1% of the general population and about 5% of individuals over 65.\"},{\"question\":\"How do current studies connect essential tremor to the cerebellum?\",\"answer\":\"The review links ET to cerebellar involvement through evidence from genetic, neuropathological, neurophysiological, and neuroimaging studies. Findings indicate abnormalities and altered connectivity within the cerebello-thalamo-cortical circuit.\"},{\"question\":\"What is the aim and scope of the narrative review?\",\"answer\":\"The review aims to synthesize findings across studies addressing ET pathophysiology, neuropathology, genetics, clinical features, neuroimaging, and treatment approaches, specifically emphasizing the cerebellum’s role in ET.\"}]","The cerebellar involvement in essential tremor: the connecting roads | PDF",1790676090]