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This narrative review synthesizes factors promoting oncogenesis, invasiveness, and the ability of renal cell carcinoma to generate secondary skin disease. Cellular stress response is presented as a central mechanism behind distant cancer-induced dermatologic events, followed by classification of malignant and non-malignant skin complications, plus treatment-related cutaneous consequences.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-cellular-stress-and-cutaneous-manifestations-in-renal-cell-carcinomas-a-narrative-review/330950/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-cellular-stress-and-cutaneous-manifestations-in-renal-cell-carcinomas-a-narrative-review/330950.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the central concept linking renal cell carcinoma to skin manifestations?","Question",{"text":112,"@type":113},"The review highlights the cellular stress response as a leading cause of dermatological events induced by cancers at distant sites.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the article categorize cutaneous complications associated with renal cancer?",{"text":117,"@type":113},"It groups them into malignant manifestations (including metastases and cutaneous malignancies linked to renal cancer), non-malignant indirect cutaneous manifestations, and treatment consequences.",{"name":119,"@type":110,"acceptedAnswer":120},"Which genetic changes are emphasized for common RCC subtypes?",{"text":121,"@type":113},"The article notes VHL gene mutation in ccRCC and describes MET mutations and chromosome-7 amplification for papillary type I, while papillary type II involves fumarate hydratase mutations and altered Nrf2-antioxidant response pathway activity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330950,1790136714,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Journal of  \nClinical Medicine  \nReview  \nThe Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review  \nCorina Daniela Ene 1,2, Ilinca Nicolae 3, Mircea Tampa 4,5, *, Simona Roxana Georgescu 4,5,*, Cosmin Ene 6,7, Clara Matei 4, Iulia Maria Teodora Leulescu 5, Cristina Iulia Mitran 8, Madalina Irina Mitran 8 and Cristina Capusa 1,2  \nCitation: Ene, C.D.; Nicolae, I.; Tampa, M.; Georgescu, S.R.; Ene, C.; Matei, C.; Leulescu, I.M.T.; Mitran, C.I.; Mitran, M.I.; Capusa, C. The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review. J. Clin. Med. 2024, 13, 3640 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)jcm13133640  \nAcademic Editor: Saum Ghodoussipour  \nReceived: 21 May 2024  \nRevised: 14 June 2024  \nAccepted: 19 June 2024  \nPublished: 21 June 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Nephrology,‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania; [corina.ene@umfcd.ro](corina.ene@umfcd.ro) (C.D.E.); [cristina.capusa@umfcd.ro](cristina.capusa@umfcd.ro) (C.C.)  \n2 Department of Nephrology,‘Carol Davila’Nephrology Hospital, 010731 Bucharest, Romania  \n3 Research Department,‘Victor Babes’ Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania; [drnicolaei@yahoo.ro](drnicolaei@yahoo.ro)  \n4 Department of Dermatology,‘Carol Davila’ University of Medicine and Pharmacy,  \n020021 Bucharest, Romania; [matei_clara@yahoo.com](matei_clara@yahoo.com)  \n5 Department of Dermatology,‘Victor Babes’ Clinical Hospital for Infectious Diseases,  \n030303 Bucharest, Romania; [iulialeulescu@gmail.com](iulialeulescu@gmail.com)  \n6 Department of Urology,‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania; [cosmin85_ene@yahoo.com](cosmin85_ene@yahoo.com)  \n7 Department of Urology,“Saint John” Clinical Emergency Hospital, 13 Vitan-Barzesti,  \n042122 Bucharest, Romania  \n8 Department of Microbiology,‘Carol Davila’ University of Medicine and Pharmacy,  \n020021 Bucharest, Romania; [cristina.iulia.mitran@gmail.com](cristina.iulia.mitran@gmail.com) (C.I.M.);  \n[madalina.irina.mitran@gmail.com](madalina.irina.mitran@gmail.com) (M.I.M.)  \n* Correspondence: [dermatology.mt@gmail.com](dermatology.mt@gmail.com) (M.T.); [srg.dermatology@gmail.com](srg.dermatology@gmail.com) (S.R.G.)  \nAbstract: The carcinomas originating from the renal cortex are the most aggressive renal malignancies, with a high tendency for metastasis. Understanding the incidence of cutaneous manifestations caused by renal carcinomas is a challenge. In the first part, this article summarizes a series of factors that promote oncogenesis, invasiveness, and the ability of renal cell carcinoma (RCC) to develop secondary cutaneous manifestations. It is postulated that the cellular stress response is one of the leading causes of developing dermatological events induced by cancers located at distant sites. Furthermore, the paper provides an overview of cutaneous complications associated with renal cancer, categorized as malignant manifestations (metastases, synchronous or metachronous cutaneous malignancies associated with renal cancer), non-malignant indirect cutaneous manifestations associated with renal cancer, and treatment consequences. The data presented in this article suggest that recognizing certain cutaneous disorders could assist the physician in the early identification of renal neoplasms and could lead to a better prognosis.  \nKeywords: renal cell carcinoma; cellular stress; secondary cutaneous manifestations  \n1. Introduction  \nIn recent decades, significant progress has been made in unde","cbCailZDGDsbLJjD","https://ap.wps.com/l/cbCailZDGDsbLJjD","pdf",1041784,18,"English","# Introduction\n# Renal cancer epidemiology and molecular mechanisms\n# Renal cell carcinoma subtypes and genetic drivers\n# Aggressiveness, metastasis patterns, and prognosis\n# Cellular stress response and pathways","[{\"question\":\"What is the central concept linking renal cell carcinoma to skin manifestations?\",\"answer\":\"The review highlights the cellular stress response as a leading cause of dermatological events induced by cancers at distant sites.\"},{\"question\":\"How does the article categorize cutaneous complications associated with renal cancer?\",\"answer\":\"It groups them into malignant manifestations (including metastases and cutaneous malignancies linked to renal cancer), non-malignant indirect cutaneous manifestations, and treatment consequences.\"},{\"question\":\"Which genetic changes are emphasized for common RCC subtypes?\",\"answer\":\"The article notes VHL gene mutation in ccRCC and describes MET mutations and chromosome-7 amplification for papillary type I, while papillary type II involves fumarate hydratase mutations and altered Nrf2-antioxidant response pathway activity.\"}]","The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas - A Narrative Review | PDF",1789990845,45]