[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-368435-105":59,"doc-detail-368435-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","the-causal-relationships-between-mitochondria-and-six-types-of-cancer-a-mendelian-randomization-study","The causal relationships between mitochondria and six types of cancer - a Mendelian randomization study","","Mitochondria influence tumorigenesis through energy metabolism, redox balance, and apoptosis, yet the causal impact of mitochondrial traits on cancer risk remains insufficiently defined. This study used Mendelian randomization to test 82 mitochondrial-related exposures for causal effects on six major cancers: hepatic, colorectal, lung, esophageal, thyroid, and breast. Two-sample MR with IVW estimation and sensitivity analyses assessed heterogeneity, pleiotropy, and directionality, identifying mitochondrial variants linked to altered cancer risks.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-causal-relationships-between-mitochondria-and-six-types-of-cancer-a-mendelian-randomization-study/368435/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-causal-relationships-between-mitochondria-and-six-types-of-cancer-a-mendelian-randomization-study/368435.png","ImageObject",300,407,{"name":92,"@type":93},"Jacob","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main objective of this Mendelian randomization study?","Question",{"text":113,"@type":114},"To evaluate whether mitochondrial traits have causal effects on the risk of six major cancer types using genetic instruments.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which statistical framework and sensitivity analyses were used?",{"text":118,"@type":114},"Two-sample MR with inverse variance weighted (IVW) estimation, complemented by MR-Egger regression and weighted median, plus Cochran’s Q, MR-Egger intercept, leave-one-out, and the Steiger test.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the study conclude about mitochondria and cancer susceptibility?",{"text":122,"@type":114},"Specific mitochondrial-related genetic traits showed causal effects on the risk of several common cancers, suggesting mitochondria contribute across cancer types via shared mechanisms and potential prevention/therapy targets.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},368435,1790216142,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Tang et al. BMC Cancer (2025) 25:794 BMC Cancer  \n[https://doi.org/10.1186/s12885-025-14201-0](https://doi.org/10.1186/s12885-025-14201-0)  \nRESEARCH Open Access  \nThe causal relationships between mitochondria and six types of cancer:  \na Mendelian randomization study  \nJincheng Tang 1†, Jingting Zhang 1†, Renyi Yang 1, Hongyao Chen 1, Xiaopeng Yu 1, Wei Peng2* and Puhua Zeng2*  \nAbstract  \nBackground Mitochondria play a multifaceted role in tumorigenesis, influencing energy metabolism, redox balance, and apoptosis. However, whether mitochondrial traits causally affect cancer risk remains unclear. This study aimed to evaluate the potential causal effects of 82 mitochondrial-related exposures on six major cancers—hepatic, colorectal, lung, esophageal, thyroid, and breast—using Mendelian randomization (MR) .  \nMethods Two-sample MR analysis was performed using the inverse variance weighted (IVW) method, with  \nMR-Egger regression and weighted median as complementary approaches. Sensitivity analyses (Cochran’s Q test, MR-Egger intercept, leave-one-out) and the Steiger test were applied to assess heterogeneity, pleiotropy, and causal directionality.  \nResults We observed a negative correlation between“39S ribosomal protein L34, mitochondrial”, and others,  \nwith hepatic cancer, while“[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial”, and others exhibited a positive correlation with hepatic cancer.“Phenylalanine-tRNA ligase, mitochondrial”, and others demonstrated a negative association with colorectal cancer, whereas“Methyl malonyl-CoA epimerase, mitochondrial”, and others exhibited a positive correlation with colorectal cancer.“Succinate dehydrogenase assembly factor 2, mitochondrial” exhibited a negative correlation with lung cancer, while“Superoxide dismutase [Mn], mitochondrial levels” showed a positive correlation with lung cancer.“Lon protease homolog, mitochondrial” demonstrated a positive correlation with esophageal cancer.“Iron-sulfur cluster assembly enzyme ISCU, mitochondrial”, and others exhibited a negative correlation with thyroid cancer, while“Diablo homolog, mitochondrial”, and others showed a positive correlation with thyroid cancer.“ADP-ribose pyrophosphatase, mitochondrial”, and others exhibited a negative correlation with breast cancer, while“39S ribosomal protein L34, mitochondrial”, and others showed a positive correlation with breast cancer.  \nConclusions This study provides MR-based evidence that specific mitochondrial-related traits have causal effects on the risk of several common cancers. Notably, certain single-nucleotide polymorphisms (SNPs) acted as instrumental  \n†Jincheng Tang and Jingting Zhang contributed equally to this work.  \n*Correspondence: Wei Peng [pengwei120120@163.com](pengwei120120@163.com)[ ](pengwei120120@163.com)Puhua Zeng [zph120@126.com](zph120@126.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](veco","cbCaidKJfwcUfwCG","https://ap.wps.com/l/cbCaidKJfwcUfwCG","pdf",3740568,13,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Keywords\n# Introduction","[{\"question\":\"What was the main objective of this Mendelian randomization study?\",\"answer\":\"To evaluate whether mitochondrial traits have causal effects on the risk of six major cancer types using genetic instruments.\"},{\"question\":\"Which statistical framework and sensitivity analyses were used?\",\"answer\":\"Two-sample MR with inverse variance weighted (IVW) estimation, complemented by MR-Egger regression and weighted median, plus Cochran’s Q, MR-Egger intercept, leave-one-out, and the Steiger test.\"},{\"question\":\"What did the study conclude about mitochondria and cancer susceptibility?\",\"answer\":\"Specific mitochondrial-related genetic traits showed causal effects on the risk of several common cancers, suggesting mitochondria contribute across cancer types via shared mechanisms and potential prevention/therapy targets.\"}]","The causal relationships between mitochondria and six types of cancer - a Mendelian randomization study | PDF",1790176935,33]