[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332770-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332770-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-causal-relationship-between-gut-microbiota-and-2-neoplasms-a-two-sample-mendelian-randomization-study","The causal relationship between gut microbiota and 2 neoplasms - A two-sample Mendelian randomization study","","Previous research indicates a close link between bone neoplasm development and differences in specific gut microbiota abundance, but causal direction remains unclear. This two-sample Mendelian randomization study evaluates genetic associations between gut microbiota taxa and malignant (MNBAC) and benign (BNBAC) bone and articular cartilage neoplasms using pooled GWAS data. Primary causal effects are estimated with inverse-variance weighted methods, with horizontal pleiotropy assessed by MR pleiotropy residual sum, outlier testing, and MR-Egger intercept. Reverse causality is evaluated by inverse MR analysis, suggesting multiple protective and risk taxa.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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question does the study address about gut microbiota and bone neoplasms?","Question",{"text":63,"@type":64},"It investigates whether gut microbiota taxa have a causal relationship with two types of bone and articular cartilage neoplasms: malignant (MNBAC) and benign (BNBAC).","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How are causal effects between gut microbiota and neoplasms estimated?",{"text":68,"@type":64},"The study uses a two-sample Mendelian randomization approach, evaluating SNPs from pooled GWAS data and applying inverse-variance weighted as the main method.",{"name":70,"@type":61,"acceptedAnswer":71},"Did the analysis find reverse causality from bone neoplasms to gut microbiota?",{"text":72,"@type":64},"No reverse causal relationship was found between the studied bone neoplasms and the referenced gut microbiota taxa.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332770,1790159044,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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malignant and benign neoplasms of bone and articular cartilage A two-sample Mendelian randomization study  \nJia Lv, DDa ,* , Xiuyu Qin, MDb , Jiani Wang, MDc , Jian Li, DDd , Junjun Bai, DDa , Yanping Lan, MDa  \n\n| Abstract\u003Cbr>Previous research has demonstrated a close connection between the development of bone neoplasms and variations in the abundance of specific gut microbiota. It remains unclear, however, how the gut microbiota and bone neoplasms are causally related. Hence, in our study, we aim to clarify this relationship between gut microbiota and 2 neoplasms, malignant neoplasm of bone and articular cartilage (MNBAC) and benign neoplasm of bone and articular cartilage (BNBAC), by employing a two-sample Mendelian randomization (MR) approach. In this study, single nucleotide polymorphisms (SNPs) from genome-wide association studies-pooled data related to bone neoplasms and gut microbiota abundance were evaluated. The inverse variance weighted was employed as the major method for assessing the aforementioned causal relationship. Furthermore, the horizontal multiplicity was evaluated utilizing the Mendelian randomization pleiotropy residual sum and outlier and the MR-Egger intercept test. Finally, inverse MR analysis was performed to assess reverse causality. Inverse variance weighted results indicate a potential genetic relationship between 4 gut microbiota and MNBAC, and 3 gut microbiota and BNBAC. On the one hand, Eubacterium eligens group (OR = 0. 16, 95% CI = 0.04–0.67, P = .01), Odoribacter (OR = 0.23, 95% CI = 0.06–0.84, P = .03), Slackia (OR = 0.35, 95% CI = 0.13–0.93, P = .04), and Tyzzerella3 (OR = 0.44, 95% CI = 0.24–0.82, P = .01) exhibited a protective effect against MNBAC. On the other hand, of the 3 gut microbes identified as potentially causally related to BNBAC, Oscillibacter (OR = 0.79, 95% CI = 0.63–0.98, P = .03) and Ruminococcus torques group (OR = 0.62, 95% CI = 0.39–0.98, P = .04) were regarded as protective strains of B, while Eubacterium ruminantium group (OR = 1.24, 95% CI = 1.04–1.47, P = .02) was considered to bea risk factor for increasing the incidence of BNBAC. Additionally, the bone neoplasms were not found to have a reverse causal relationship with the above 7 gut microbiota taxa. Four gut microbiota showed causal effects on MNBAC, and 3 gut microbiota demonstrated causality in BNBAC, providing insights into the design of future interventions to reduce the burden of neoplasms. |\n| --- |\n| Abbreviations: BNBAC = benign neoplasm of bone and articular cartilage, GWAS = genome-wide association studies, IVs = instrumental variables, IVW = inverse variance weighted, MNBAC = malignant neoplasm of bone and articular cartilage, MR = Mendelian randomization, SNPs = single nucleotide polymorphisms. |\n| Keywords: articular, bone, causal inference, gut microbiota, Mendelian randomization study, neoplasm |\n\n1. Introduction  \nBone neoplasms, which include both primary and metastatic neoplasms, represent a rare and heterogeneous group of neoplasms that occur in the bone. According to the publication of the fifth edition of the World Health Organization’s classification of tumors of soft tissue and bone in 2020, Choi et al summarized and stated that among primary bone tumors, benign bone tumors include osteoid osteoma, osteochondroma, and  \nchondroma, while malignant bone tumors include osteosarcoma, chondrosarcoma, fibrosarcoma of bone, Ewing sarcoma, and chordoma. [1] For the majority of bone tumors, localized pain, swelling, and functional restrictions are the primary clinical symptoms. When it comes to the location of growth, bone tumors occur more frequently in the epiphyses of long bones, such as the femur, tibia, and humerus.[2] Compared with benign bone tumors, malignant bone tumors cause significantly more  \nThe authors have no funding and conflicts of interest to disclose. The datasets generated during and/o","cbCaiofqMZVk9Htd","https://ap.wps.com/l/cbCaiofqMZVk9Htd","pdf",962384,"English","# Introduction\n## Background and classification of bone neoplasms\n## Clinical features and distribution\n# Methods (from abstract)\n## Two-sample Mendelian randomization approach\n## Assessment of pleiotropy and reverse causality","[{\"question\":\"What question does the study address about gut microbiota and bone neoplasms?\",\"answer\":\"It investigates whether gut microbiota taxa have a causal relationship with two types of bone and articular cartilage neoplasms: malignant (MNBAC) and benign (BNBAC).\"},{\"question\":\"How are causal effects between gut microbiota and neoplasms estimated?\",\"answer\":\"The study uses a two-sample Mendelian randomization approach, evaluating SNPs from pooled GWAS data and applying inverse-variance weighted as the main method.\"},{\"question\":\"Did the analysis find reverse causality from bone neoplasms to gut microbiota?\",\"answer\":\"No reverse causal relationship was found between the studied bone neoplasms and the referenced gut microbiota taxa.\"}]","The causal relationship between gut microbiota and 2 neoplasms - A two-sample Mendelian randomization study | PDF",1789999433]