[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-442949-en":59,"doc-seo-442949-105":80},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":72,"language_code":73,"site_id":74,"html_lang":73,"table_of_contents":75,"faqs":76,"seo_title":77,"seo_description":66,"update_tm":78,"read_time":79},442949,3985747870733,"acoobca","https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","The Carillon device in the treatment of patients with functional mitral regurgitation - Device Evaluation - clinical overview","Functional mitral regurgitation (FMR), driven by left ventricular and mitral annulus dilation rather than primary valve damage, is common in heart failure and worsens prognosis. The Carillon® Mitral Contour System is a minimally invasive trans-coronary-venous indirect annuloplasty that reduces annular dimensions and improves leaflet coaptation while avoiding transseptal access. Its leaflet-sparing extracardiac mechanism preserves options for future transcatheter therapies and supports left ventricular pacing for CRT. This article summarizes clinical studies, real-world registries, and effectiveness for FMR, plus future application perspectives.","FUTURE CARDIOLOGY  \n2026, VOL. 22, NO. 1, 23–32  \n[https://doi.org/10.1080/14796678.2025.2606568](https://doi.org/10.1080/14796678.2025.2606568)  \n| DEVICE EVALUATION   \u003Cbr>The Carillon device in the treatment of patients with functional mitral regurgitation\u003Cbr>Piotr Kałmuckia, Karolina Owsikb, Artur Baszkoa and Tomasz Siminiaka\u003Cbr>aInterventional Cardiology, Poznań University of Medical Sciences, Poznan, Poland; bDepartment Interventional Cardiology, HCP Medical Centre, Poznan, Poland |  |  |\n| --- | --- | --- |\n| ABSTRACT\u003Cbr>Functional mitral regurgitation (FMR), secondary to left ventricle and mitral annulus dilation, is a frequent and prognostically adverse complication of heart failure. Several different transcatheter approaches were developed as therapeutic options in high-risk patients. Among them, the Carillon® Mitral Contour System, which offers a minimally invasive, trans- coronary-venous approach to indirect annuloplasty that reduces annular dimensions and improves leaflet coaptation without the need for transseptal access or manipulation of the mitral valve apparatus. A key advantage of Carillon lies in its extracardiac, leaflet-sparing mechanism. By acting from the lumen of coronary sinus and great cardiac vein, the device preserves the possibility of future interventions such as transcatheter edge-to-edge repair, direct annuloplasty, or even valve replacement, while still allowing successful placement of left ventricular pacing leads for cardiac resynchronization therapy. The current article provides the Carillon device characteristics and technical aspects of implantation procedure. The paper is an overview of the clinical studies and real-world registries conducted on the Carillon device, and the effectiveness of this treatment for functional mitral regurgitation. We also discuss possible future perspectives of the Carillon device applications like treating patients with mild FMR, in combination with other treatment modalities, approaches or atrial form of FMR.\u003Cbr>PLAIN LANGUAGE SUMMARY\u003Cbr>Functional mitral regurgitation is a condition in which the mitral valve leaks because the heart’s main pumping chamber, the left ventricle, is enlarged or weakened. This leakage can make heart failure symptoms worse and reduce quality of life. Many patients with functional mitral regurgitation cannot have open-heart surgery because of their overall health or advanced heart failure. The Carillon Mitral Contour System is a minimally invasive device placed through a vein in the neck. It works by gently reshaping the area around the mitral valve to help it close more completely and reduce backward blood flow. Unlike some other procedures, it does not require crossing into the heart chambers and does not affect the valve leaflets, which allows future treatment options to remain available. Clinical studies have shown that Carillon therapy can reduce the degree of regurgitation, improve heart size and function, and help patients feel better and stay out of the hospital. Ongoing large studies are continuing to determine whether these improvements lead to longer survival. |  | ARTICLE HISTORY\u003Cbr>Received 23 October 2025 Accepted 16 December 2025\u003Cbr>KEYWORDS\u003Cbr>Carillon; coronary sinus; functional mitral regurgitation; heart failure; mitral annuloplasty |\n| 1. Introduction | approach that prioritizes guideline-directed medical therapy |  |\n| Functional mitral valve regurgitation (FMR) is defined as | (GDMT), or cardiac resynchronization therapy (CRT) [6, 12–14], |  |\n| a condition caused not by intrinsic valvular pathology, but by | which may reduce the severity of mitral regurgitation and |  |\n| left ventricular (LV) dysfunction and dilation of ischemic or non- | improve outcomes. However, benefits of GDMT are often lim- |  |\n| ischemic origin [1–3]. The predominant etiologies comprise | ited and inconsistent, achieved in fewer than half of patients |  |\n| complications of myocardial infarction and dilated cardiomyo- | with FMR who a","cbCaiqndnXD7Ywz2","https://ap.wps.com/l/cbCaiqndnXD7Ywz2","pdf",3468236,"English","en",105,"# Abstract\n## Plain Language Summary\n## Article Background and Rationale\n## Device Approach and Technical Considerations\n## Clinical Evidence and Real-World Registries\n## Safety, Outcomes, and Future Perspectives","[{\"question\":\"What causes functional mitral regurgitation (FMR) and why is it clinically important?\",\"answer\":\"FMR results from left ventricular dysfunction and dilation that lead to mitral annulus enlargement, not intrinsic valve pathology. It is associated with higher cardiovascular mortality and morbidity and increased heart failure hospitalizations.\"},{\"question\":\"How does the Carillon® Mitral Contour System work?\",\"answer\":\"The device is delivered via a trans-coronary-venous approach and performs indirect annuloplasty by gently reshaping the mitral annulus region. It improves leaflet coaptation, reduces regurgitation, and is leaflet-sparing.\"},{\"question\":\"What advantages does Carillon offer regarding future treatment options?\",\"answer\":\"Because it acts without needing transseptal access and preserves the valve leaflets, future interventions such as transcatheter edge-to-edge repair, direct annuloplasty, or even valve replacement remain feasible. It also supports placement of left ventricular pacing leads for CRT.\"}]","The Carillon device in the treatment of patients with functional mitral regurgitation - Device Evaluation - clinical overview | PDF",1790702278,25,{"code":4,"msg":81,"data":82},"ok",{"site_id":74,"language":73,"slug":83,"title":65,"keywords":84,"description":66,"schema_data":85,"social_meta":139,"head_meta":141,"extra_data":143,"updated_unix":144},"the-carillon-device-in-the-treatment-of-patients-with-functional-mitral-regurgitation-device-evaluation-clinical-overview","",{"@graph":86,"@context":138},[87,101,121],{"@type":88,"itemListElement":89},"BreadcrumbList",[90,94,96,99],{"item":91,"name":92,"@type":93,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":95,"name":9,"@type":93,"position":14},"https://docshare.wps.com/document/",{"item":97,"name":35,"@type":93,"position":98},"https://docshare.wps.com/document/healthcare/",3,{"item":100,"name":65,"@type":93,"position":19},"https://docshare.wps.com/document/the-carillon-device-in-the-treatment-of-patients-with-functional-mitral-regurgitation-device-evaluation-clinical-overview/442949/",{"url":100,"name":65,"@type":102,"image":103,"author":108,"headline":65,"publisher":110,"fileFormat":113,"inLanguage":73,"description":66,"dateModified":114,"datePublished":115,"encodingFormat":113,"isAccessibleForFree":116,"interactionStatistic":117},"DigitalDocument",{"url":104,"@type":105,"width":106,"height":107},"https://docshare.wps.com/thumbnails/the-carillon-device-in-the-treatment-of-patients-with-functional-mitral-regurgitation-device-evaluation-clinical-overview/442949.png","ImageObject",300,407,{"name":63,"@type":109},"Person",{"url":91,"name":111,"@type":112},"DocShare","Organization","application/pdf","2026-10-01","2026-09-29",true,{"@type":118,"interactionType":119,"userInteractionCount":19},"InteractionCounter",{"@type":120},"ViewAction",{"@type":122,"mainEntity":123},"FAQPage",[124,130,134],{"name":125,"@type":126,"acceptedAnswer":127},"What causes functional mitral regurgitation (FMR) and why is it clinically important?","Question",{"text":128,"@type":129},"FMR results from left ventricular dysfunction and dilation that lead to mitral annulus enlargement, not intrinsic valve pathology. It is associated with higher cardiovascular mortality and morbidity and increased heart failure hospitalizations.","Answer",{"name":131,"@type":126,"acceptedAnswer":132},"How does the Carillon® Mitral Contour System work?",{"text":133,"@type":129},"The device is delivered via a trans-coronary-venous approach and performs indirect annuloplasty by gently reshaping the mitral annulus region. It improves leaflet coaptation, reduces regurgitation, and is leaflet-sparing.",{"name":135,"@type":126,"acceptedAnswer":136},"What advantages does Carillon offer regarding future treatment options?",{"text":137,"@type":129},"Because it acts without needing transseptal access and preserves the valve leaflets, future interventions such as transcatheter edge-to-edge repair, direct annuloplasty, or even valve replacement remain feasible. It also supports placement of left ventricular pacing leads for CRT.","https://schema.org",{"og:url":100,"og:type":140,"og:title":65,"og:site_name":111,"og:description":66},"article",{"robots":142,"canonical":100},"index,follow",{"doc_id":61,"site_id":74},1790736721]