[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380699-105":59,"doc-detail-380699-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-capability-of-heterogeneous-gd-t-cells-in-cancer-treatment","The capability of heterogeneous gd T cells in cancer treatment","","Heterogeneous γδ T cells constitute a specialized T lymphocyte subset increasingly highlighted in cancer immunotherapy. Positioned at the interface of innate and adaptive immunity, these cells display a broad tumor-recognition capacity and can directly identify and eliminate tumor cells without dependence on HLA-antigen presentation. They can also present tumor antigens to αβ T cells, enhancing antitumor efficacy. Distinct γδ T cell subpopulations may exert anti-tumor or pro-tumor functions within the tumor microenvironment, and understanding their functional plasticity supports their strategic use in malignant tumor treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-capability-of-heterogeneous-gd-t-cells-in-cancer-treatment/380699/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-capability-of-heterogeneous-gd-t-cells-in-cancer-treatment/380699.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-26","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes γδ T cells distinct from classical CD4+ and CD8+ αβ T cells?","Question",{"text":112,"@type":113},"γδ T cells are named for the γ and δ chains in their T cell receptor, rather than the α and β chains found in classical αβ T cells (CD4+ and CD8+). They represent a transitional state between adaptive and innate immunity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do γδ T cells contribute to antitumor effects in cancer treatment?",{"text":117,"@type":113},"They can directly identify and eliminate tumor cells without relying on HLA-antigen presentation. They also can present tumor antigens to αβ T cells, thereby amplifying antitumor efficacy.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is functional heterogeneity of γδ T cells important?",{"text":121,"@type":113},"Different γδ T cell subpopulations can show distinct immune functions, including anti-tumor or pro-tumor roles within the tumor microenvironment. Strategically harnessing these heterogeneous cohorts is pivotal for their integration into tumor-specific immunotherapeutic approaches.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380699,1790386201,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","TYPE Review  \nPUBLISHED 24 November 2023 DOI 10.3389/fimmu.2023.1285801  \nOPEN ACCESS  \nEDITED BY Yao Wang,  \nChinese PLA General Hospital, China  \nREVIEWED BY Min Chen,  \nChongqing Medical University, China Likai Tan,  \nThe Chinese University of Hong Kong, China Ruoyang Liu,  \nUnicet Biotech, China Michael Uhlin,  \nKarolinska Institutet, Sweden  \n*CORRESPONDENCE Pengju Wang  \n [wangpengju@zzu.edu.cn](wangpengju@zzu.edu.cn)[ ](wangpengju@zzu.edu.cn)Yafeng Wang  \n[yfwang@zzu.edu.cn](yfwang@zzu.edu.cn)  \nRECEIVED 30 August 2023  \nACCEPTED 06 November 2023  \nPUBLISHED 24 November 2023  \nCITATION  \nYan W, Dunmall LSC, Lemoine NR, Wang Y, Wang Y and Wang P (2023) The capability of heterogeneous gd T cells in cancer treatment.  \nFront. Immunol. 14:1285801 .  \ndoi: 10.3389/fimmu.2023.1285801  \nCOPYRIGHT  \n© 2023 Yan, Dunmall, Lemoine, Wang, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe capability of heterogeneous gd T cells in cancer treatment  \nWenyi Yan 1, Louisa S. Chard Dunmall 2, Nicholas R. Lemoine 1,2, Yaohe Wang 1,2, Yafeng Wang 3* and Pengju Wang 1*  \n1Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, State Key Laboratory of Esophageal Cancer Prevention & Treatment, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China, 2Centre for Biomarkers & Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom, 3State Key Laboratory of Esophageal Cancer Prevention & Treatment, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China  \ngd T cells, a specialized subset of T lymphocytes, have garnered significant attention within the realm of cancer immunotherapy. Operating at the nexus between adaptive and innate immunological paradigms, these cells showcase a profound tumor discernment repertoire, hinting at novel immunotherapeutic strategies. Significantly, these cells possess the capability to directly identify and eliminate tumor cells without reliance on HLA-antigen presentation. Furthermore, gd T cells have the faculty to present tumor antigens to ab T cells, amplifying their anti-tumoral efficacy. Within the diverse and heterogeneous subpopulations of gd T cells, distinct immune functionalities emerge, manifesting either anti-tumor or pro-tumor roles within the tumor microenvironment. Grasping and strategically harnessing these heterogeneous gd T cell cohorts is pivotal to their integration in tumor-specificimmunotherapeutic modalities. The aim of this review is to describe the heterogeneity of the gd T cell lineage and the functional plasticity it generatesin the treatment of malignant tumors. This review endeavors to elucidate the intricate heterogeneity inherent to the gd T cell lineage, the consequential functional dynamics in combating malignancies, the latest advancements from clinical trials, and the evolving landscape of gd T cell-based oncological interventions, while addressing the challenges impeding the field.  \nKEYWORDS  \ngd T cells, T cell subsets, heterogeneity, CAR-gd T, adoptive cell transfer therapy, cancer immunotherapy  \n1 Introduction  \nThere is a distinct and conserved population ofT lymphocytes called gd T cells, named for the g and d chains making up the T cell receptor (TCR) that sets them apart from the classical T cells (CD4+ and CD8+) that contain ab TCRs. They represent a distinctive subset of T cells that exist in a transitional state between the adaptive and innate immune systems (1–3) . Functionally, there is com","cbCaidzl1zO8iZiw","https://ap.wps.com/l/cbCaidzl1zO8iZiw","pdf",2060448,14,"English","# Introduction\n# Development and differentiation of human γδ T cells","[{\"question\":\"What makes γδ T cells distinct from classical CD4+ and CD8+ αβ T cells?\",\"answer\":\"γδ T cells are named for the γ and δ chains in their T cell receptor, rather than the α and β chains found in classical αβ T cells (CD4+ and CD8+). They represent a transitional state between adaptive and innate immunity.\"},{\"question\":\"How do γδ T cells contribute to antitumor effects in cancer treatment?\",\"answer\":\"They can directly identify and eliminate tumor cells without relying on HLA-antigen presentation. They also can present tumor antigens to αβ T cells, thereby amplifying antitumor efficacy.\"},{\"question\":\"Why is functional heterogeneity of γδ T cells important?\",\"answer\":\"Different γδ T cell subpopulations can show distinct immune functions, including anti-tumor or pro-tumor roles within the tumor microenvironment. Strategically harnessing these heterogeneous cohorts is pivotal for their integration into tumor-specific immunotherapeutic approaches.\"}]","The capability of heterogeneous gd T cells in cancer treatment | PDF",1790241371,35]