[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332998-105":59,"doc-detail-332998-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-burden-of-cancer-in-metabolic-dysfunction-associated-steatotic-liver-disease","The burden of cancer in metabolic dysfunction-associated steatotic liver disease","","Metabolic dysfunction-associated steatotic liver disease (MASLD) is identified as the most prevalent chronic liver disease worldwide and a major public health challenge. MASLD commonly progresses to cirrhosis and hepatocellular carcinoma, and recent evidence links it to extrahepatic cancers. Central mechanisms include insulin resistance and hyperinsulinemia. This narrative review aims to summarize the main etiopathogenic pathways driving cancer development in patients with MASLD.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-burden-of-cancer-in-metabolic-dysfunction-associated-steatotic-liver-disease/332998/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-burden-of-cancer-in-metabolic-dysfunction-associated-steatotic-liver-disease/332998.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is MASLD and why is it considered a major public health problem?","Question",{"text":112,"@type":113},"MASLD is described as the most prevalent chronic liver disease worldwide. It is emphasized as a major public health issue due to its frequent progression and cancer associations.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cancers are frequently associated with MASLD?",{"text":117,"@type":113},"MASLD is linked to hepatocellular carcinoma (HCC) and has also been reported as frequently associated with extrahepatic cancers.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanisms are discussed as contributors to cancer development in MASLD?",{"text":121,"@type":113},"Insulin resistance and hyperinsulinemia are highlighted as key mechanisms. The review also discusses systemic inflammation, metabolic dysregulation, altered insulin receptor isoforms, impaired apoptosis, and DNA damage leading to mutations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332998,1790148864,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Rom J Morphol Embryol 2024, 65(4):627–635 ISSN (print) 1220–0522, ISSN (online) 2066–8279 doi: 10.47162/RJME.65.4.09  \nREVIEW  \nR J M E  \nRomanian Journal of Morphology & Embryology  \n[http://www.rjme.ro/](http://www.rjme.ro/)  \nThe burden of cancer in metabolic dysfunction-associated steatotic liver disease  \nBIANCA FLORENTINA PÎRVU1), DIANA CLENCIU2), LUIZA ANDREEA BELDIE1), CRISTINA CAMELIA DICA1),  \nMARILENA ALEXANDRA BURTICALĂ1), TIBERIU ŞTEFĂNIŢĂ ŢENEA-COJAN3), ADINA MITREA2), ANCA MARIA AMZOLINI4), ION CRISTIAN EFREM5), GABRIEL FLORIN RĂZVAN MOGOŞ3), IONELA MIHAELA VLADU2)  \n1) Department of Diabetes, Nutrition and Metabolic Diseases, Emergency County Clinical Hospital, Craiova, Romania  \n2) Department of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania  \n3) Department of General Surgery, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania  \n4) Department of Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania  \n5) Department of Medical Semiology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania  \nAbstract  \nMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and has become a major public health problem. MASLD frequently progresses to cirrhosis and hepatocellular carcinoma, but recent studies also show a frequent association with extrahepatic cancers. One of the mechanisms involved in both locations is insulin resistance and hyperinsulinemia. The aim of this narrative review was to present the main etiopathogenic mechanisms involved in cancer development in patients with MASLD.  \nKeywords: metabolic dysfunction-associated steatotic liver disease, cancer, insulin resistance, metabolic syndrome, insulin receptor isoforms.  \n􀀕 Introduction  \nMetabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has emerged as a primary risk factor for cancer, particularly hepatocellular carcinoma (HCC) and given its strong and complex relationship with metabolic syndrome that impacts hepatic and extrahepatic tissues, its influence extends beyond the liver, creating a systemic environment conductive to carcinogenesis in extrahepatic tissues as well [1, 2]. Recent studies have shown the global prevalence of MASLD ranges between 30–33%[3]. As the prevalence of MASLD has increased, so has the incidence of MASLD-related HCC [4] . Significant long-term risks are associated with MASLD progression, as individuals with MASLD can develop cirrhosis and HCC [5] . HCC represents a significant health issue, with a high mortality rate and representing up to 80% of primary liver cancers [6] . Furthermore, this surge in MASLD-associated HCCis of particular concern, because of its effects on broader demographics. For example, in Western nations, the growing rise and burden of metabolic disorders impacts heavily on the growing incidence of HCC [7] . Studies project an increase rate in all countries, with an alarming 130% increase in USA between 2016–2030 underscoring the urgent need for public health strategies to address the underlaying metabolic risk factors [8] .  \nMASLD and metabolic syndrome are deeply intertwined,  \nexcessive fat accumulation in liver cells leads to progressive liver damage, fibrosis and heightens the risk of HCC [1, 9] . Changes in the metabolic environment can lead to alterationsin the normal activity of liver, which has a unique role in regulating metabolism through its dual blood supply, from both portal and systemic circulation [9]. The pathological process within MASLD, contributes to a persistent state of systemic inflammation, hyperinsulinemia and metabolic dysregulation that exerts systemic effects on gastrointestinal (GI), renal, heart and muscle tissues and alters the normal activation of various signaling cascades [3] . ","cbCair8K21gUf5Xy","https://ap.wps.com/l/cbCair8K21gUf5Xy","pdf",1621914,"English","# Abstract\n# Introduction\n# MASLD progression and pathogenesis","[{\"question\":\"What is MASLD and why is it considered a major public health problem?\",\"answer\":\"MASLD is described as the most prevalent chronic liver disease worldwide. It is emphasized as a major public health issue due to its frequent progression and cancer associations.\"},{\"question\":\"Which cancers are frequently associated with MASLD?\",\"answer\":\"MASLD is linked to hepatocellular carcinoma (HCC) and has also been reported as frequently associated with extrahepatic cancers.\"},{\"question\":\"What mechanisms are discussed as contributors to cancer development in MASLD?\",\"answer\":\"Insulin resistance and hyperinsulinemia are highlighted as key mechanisms. The review also discusses systemic inflammation, metabolic dysregulation, altered insulin receptor isoforms, impaired apoptosis, and DNA damage leading to mutations.\"}]","The burden of cancer in metabolic dysfunction-associated steatotic liver disease | PDF",1790000316,23]