[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332246-105":59,"doc-detail-332246-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-bioenergetic-landscape-of-cancer-review","The bioenergetic landscape of cancer - Review","","Bioenergetic remodeling of core energy metabolism is essential to cancer cell initiation, survival, and progression through ATP and metabolic intermediate supply, alongside maintenance of redox homeostasis. Mitochondria, conserved for energetic plasticity and adaptive potential, couple ATP synthesis to oxidation of diverse substrates from multiple metabolic pathways. Targeting this mitochondrial bioenergetic system—by limiting metabolite availability, inhibiting respiratory Complexes, modifying organelle structure, or reducing coupling efficiency—may constrain carcinogenic potential and tumor progression. The review highlights therapeutic opportunities in mitochondrial targeting.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-bioenergetic-landscape-of-cancer-review/332246/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-bioenergetic-landscape-of-cancer-review/332246.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is bioenergetic remodeling important for cancer cells?","Question",{"text":112,"@type":113},"It supports cancer cell initiation, survival, and progression by enabling ATP and metabolic intermediate availability and by controlling redox homeostasis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do mitochondria contribute to cancer survival and progression?",{"text":117,"@type":113},"They provide required energy and metabolites, influence signaling to confer plasticity, and support ATP synthesis driven by cellular respiration.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategies does the review suggest for targeting cancer bioenergetics?",{"text":121,"@type":113},"Limiting oxidative efficiency or restricting mitochondrial bioenergetic functions via metabolite availability control, respiratory Complex inhibition, organelle structural changes, or coupling-efficiency disruption.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332246,1790192755,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Review  \nThe bioenergetic  \nlandscape of cancer  \nElizabeth R.M. Zunica1, Christopher L. Axelrod1, L. Anne Gilmore2, Erich Gnaiger 3, John P. Kirwan1, *  \nABSTRACT  \nBackground: Bioenergetic remodeling of core energy metabolism is essential to the initiation, survival, and progression of cancer cells through exergonic supply of adenosine triphosphate (ATP) and metabolic intermediates, as well as control of redox homeostasis. Mitochondria are evolutionarily conserved organelles that mediate cell survival by conferring energetic plasticity and adaptive potential. Mitochondrial ATP synthesis is coupled to the oxidation of a variety of substrates generated through diverse metabolic pathways. As such, inhibition of the mitochondrial bioenergetic system by restricting metabolite availability, direct inhibition of the respiratory Complexes, altering organelle structure, or coupling efficiency may restrict carcinogenic potential and cancer progression.  \nScope of Review: Here, we review the role of bioenergetics as the principal conductor of energetic functions and carcinogenesis while highlighting the therapeutic potential of targeting mitochondrial functions.  \nMajor Conclusions: Mitochondrial bioenergetics significantly contribute to cancer initiation and survival. As a result, therapies designed to limit oxidative efficiency may reduce tumor burden and enhance the efficacy of currently available antineoplastic agents.  \n􀀁 2024 The Author(s) . Published by Elsevier GmbH. This is an open access article under the CC BY-NC license ([http://creativecommons.org/licenses/by-nc/4.0/](http://creativecommons.org/licenses/by-nc/4.0/)) .  \nKeywords Mitochondria; Cancer; Bioenergetics; Energy transformation; Cell survival  \n1. BACKGROUND  \nCancer cells require energy to grow, perform work, transform, and replicate. Like all eukaryotic cells, adenosine triphosphate (ATP) in cancer cells serves as the principal form of chemical energy, which is made available through a variety of energy transformation processes. Over the past 100 years, multiple theories have emerged attempting to explain how and why bioenergetic adaptation occurs in cancer. However, it is now generally accepted that nutrient availability and need influence cancer cell metabolism heterogeneity and that a dynamic interplay between cancer cells and the tumor microenvironment (TME) enable metabolic flexibility to support tumor growth, cancer progression, and evasion of death [1e3] .  \nMitochondria are essential to cancer survival and progression by providing the energy and metabolites required to initiate and sustain growth, as well as modulate signaling process to confer plasticity in changing environments [4] . Bioenergetics govern the dynamic, multifaceted biology of mitochondria and more broadly, the cell, and are critical to cancer cell initiation, survival, and progression. A primary mechanism whereby mitochondria aid in cell survival is through the synthesis of ATP resulting from cellular respiration. However, the specific influence of mitochondrial respiratory function to survival of cancer cells or tumors remains incompletely understood.  \nHere, we review cancer cell metabolism with a specific focus on mitochondrial bioenergetics as a principal conductor of carcinogenesis and cancer progression. More specifically, we highlight how conserved bioenergetic processes are hijacked and/or used to support neoplastic  \nformation, expansion, and cellular resilience. We discuss recent advances in the perturbation of energetic processes as it pertains to carcinogenic potential and the development of targeted therapies for cancer treatment.  \n2. BIOENERGETICS AS THE CONDUCTOR OF MITOCHONDRIAL FUNCTIONS  \n2.1. Mitochondrial structure is critical for function  \nMitochondria evolved to be highly conserved organelles of eukaryotic cells due to their remarkable ability to enable energy transformation and support biosynthetic demand [5,6] . In mammals, mitochondrial bioenergetics encompasses the ener","cbCainU0S84fRGeX","https://ap.wps.com/l/cbCainU0S84fRGeX","pdf",1867895,16,"English","# Abstract\n# Background\n# Bioenergetics as the conductor of mitochondrial functions\n## Mitochondrial structure is critical for function","[{\"question\":\"Why is bioenergetic remodeling important for cancer cells?\",\"answer\":\"It supports cancer cell initiation, survival, and progression by enabling ATP and metabolic intermediate availability and by controlling redox homeostasis.\"},{\"question\":\"How do mitochondria contribute to cancer survival and progression?\",\"answer\":\"They provide required energy and metabolites, influence signaling to confer plasticity, and support ATP synthesis driven by cellular respiration.\"},{\"question\":\"What therapeutic strategies does the review suggest for targeting cancer bioenergetics?\",\"answer\":\"Limiting oxidative efficiency or restricting mitochondrial bioenergetic functions via metabolite availability control, respiratory Complex inhibition, organelle structural changes, or coupling-efficiency disruption.\"}]","The bioenergetic landscape of cancer - Review | PDF",1789997513]