[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-383416-105":59,"doc-detail-383416-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-baff-april-system-in-cancer-review","The BAFF-APRIL System in Cancer - review","","B cell-activating factor (BAFF; CD257/TNFSF13B/BLyS) and proliferation-inducing ligand (APRIL; CD256/TNFSF13) are members of the TNF family that shape B-cell differentiation, survival, and humoral immunity. They signal through shared and distinct pathways via receptors including BCMA, TACI, and BAFF-R, with species-specific features. Evidence links dysregulated BAFF-APRIL expression to impaired immune homeostasis, loss of tolerance, and enhanced cancer proliferation and invasion. The review synthesizes roles in hematological and solid cancers and highlights emerging targeted therapies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-baff-april-system-in-cancer-review/383416/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-baff-april-system-in-cancer-review/383416.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are BAFF and APRIL, and why are they important in cancer?","Question",{"text":112,"@type":113},"BAFF and APRIL are TNF-family ligands that regulate B-cell differentiation, survival, and function. Aberrant BAFF-APRIL production disrupts immune homeostasis and is associated with increased cancer cell proliferation and invasion.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which receptors mediate BAFF and APRIL signaling?",{"text":117,"@type":113},"BAFF and APRIL interact with receptors including BCMA and TACI, while BAFF specifically also binds BAFF-R. These receptor interactions control immune tolerance and contribute to cancer-related pathogenic processes.",{"name":119,"@type":110,"acceptedAnswer":120},"How do expression patterns of BAFF and APRIL differ in healthy tissues versus tumors?",{"text":121,"@type":113},"BAFF is highly expressed in peripheral blood mononuclear cells and secondary lymphoid organs, whereas APRIL is detectable at low levels in healthy tissues. APRIL becomes upregulated in many tumor cell lines, and both are influenced by immune stimulation signals.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383416,1791288446,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","cancers   \nReview  \nThe BAFF-APRIL System in Cancer  \nMd Ashik Ullah 1 and Fabienne Mackay 1,2,3,4, *  \nCitation: Ullah, M.A.; Mackay, F. The BAFF-APRIL System in Cancer. Cancers 2023, 15, 1791. [https://](https://)[ ](https://)[doi.org/10.3390/cancers15061791](doi.org/10.3390/cancers15061791)  \nAcademic Editor: Lorraine A. O'Reilly  \nReceived: 19 January 2023  \nRevised: 13 March 2023  \nAccepted: 13 March 2023  \nPublished: 16 March 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Laboratory of B-Lymphocytes in Autoimmunity and Malignancies, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia  \n2 The Department of Microbiology and Immunology, Faculty of Medicine, Dentistry and Health Sciences, School of Biomedical Sciences, University of Melbourne, Parkville, VIC 3010, Australia  \n3 The Department of Immunology and Pathology, Monash University, Prahran, VIC 3004, Australia  \n4 Faculty of Medicine, University of Queensland, Brisbane, QLD 4006, Australia  \n* Correspondence: [fabienne.mackay@qimrberghofer.edu.au](fabienne.mackay@qimrberghofer.edu.au); Tel.: +61-73-362-0203  \nSimple Summary: The ligands BAFF and APRIL and their cognate receptors are critical for the differentiation, survival, and function of B cells and, as such, the maintenance of humoral immunity. The BAFF-APRIL system also modulates, either directly or indirectly, the function of other immune and non-immune cells. Clinical and experimental evidence suggests that aberrant BAFF-APRIL production impairs immune homeostasis, breaks immune tolerance, and aggravates cancer cell proliferation and invasion. Here, we have reviewed the latest understanding of the role of the BAFF-APRIL system in cancer. Greater clarity on the exact involvement of these two factors in cancer will pave the way for identifying new biomarkers for early diagnosis and developing novel therapeutic strategies.  \nAbstract: B cell-activating factor (BAFF; also known as CD257, TNFSF13B, BLyS) and a proliferationinducing ligand (APRIL; also known as CD256, TNFSF13) belong to the tumor necrosis factor (TNF) family. BAFF was initially discovered as a B-cell survival factor, whereas APRIL was first identified asa protein highly expressed in various cancers. These discoveries were followed by over two decades of extensive research effort, which identified overlapping signaling cascades between BAFF and APRIL, controlling immune homeostasis in health and driving pathogenesis in autoimmunity and cancer, the latter being the focus of this review. High levels of BAFF, APRIL, and their receptors have been detected in different cancers and found to be associated with disease severity and treatment response. Here, we have summarized the role of the BAFF-APRIL system in immune cell differentiation and immune tolerance and detailed its pathogenic functions in hematological and solid cancers. We also highlight the emerging therapeutics targeting the BAFF-APRIL system in different cancer types.  \nKeywords: BAFF; APRIL; BAFF-R; TACI; BCMA; B Cell; hematological cancers; solid cancers  \n1. Introduction  \nBAFF and APRIL are homotrimeric type II transmembrane proteins that are proteolytically cleaved to produce soluble forms [1,2] . The soluble forms of these ligands are detected as homo-and heterotrimeric molecules, while BAFF also exists as 20-trimer assemblies under certain conditions [3–5] . Human BAFF and APRIL bind with high affinity to two receptors: B-cell maturation antigen (BCMA; also known as TNFRSF17) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI; also known as TNFRSF13B) [6,7] . There are species differences, however, as murine BAFF b","cbCaiuaqOKl8FIqo","https://ap.wps.com/l/cbCaiuaqOKl8FIqo","pdf",1840016,32,"English","# Simple Summary\n# Abstract\n# Keywords\n# 1. Introduction\n# 2. Expression Profile of BAFF, APRIL and Receptors","[{\"question\":\"What are BAFF and APRIL, and why are they important in cancer?\",\"answer\":\"BAFF and APRIL are TNF-family ligands that regulate B-cell differentiation, survival, and function. Aberrant BAFF-APRIL production disrupts immune homeostasis and is associated with increased cancer cell proliferation and invasion.\"},{\"question\":\"Which receptors mediate BAFF and APRIL signaling?\",\"answer\":\"BAFF and APRIL interact with receptors including BCMA and TACI, while BAFF specifically also binds BAFF-R. These receptor interactions control immune tolerance and contribute to cancer-related pathogenic processes.\"},{\"question\":\"How do expression patterns of BAFF and APRIL differ in healthy tissues versus tumors?\",\"answer\":\"BAFF is highly expressed in peripheral blood mononuclear cells and secondary lymphoid organs, whereas APRIL is detectable at low levels in healthy tissues. APRIL becomes upregulated in many tumor cell lines, and both are influenced by immune stimulation signals.\"}]","The BAFF-APRIL System in Cancer - review | PDF",1790256877,81]