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Glucose transporter 1 (GLUT1) shows correlations with miRNAs, but the contribution of miRNA10a combined with glucose upregulation to oral squamous cell carcinoma (OSCC) in diabetes remains unclear. This pilot study assessed miRNA10a and GLUT1 expression in OSCC, precancerous, and healthy tissues using quantitative RT-PCR, reporting fold-change differences and statistical group comparisons.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-association-of-mirna10a-and-glucose-transporters-in-oral-squamous-cell-carcinoma-with-diabetes-a-pilot-study/326852/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-association-of-mirna10a-and-glucose-transporters-in-oral-squamous-cell-carcinoma-with-diabetes-a-pilot-study/326852.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the aim of this pilot study?","Question",{"text":112,"@type":113},"To investigate the expression levels of miRNA10a and GLUT1 in OSCC patients with diabetes and to evaluate related differences across OSCC, precancerous, and healthy tissues.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were miRNA10a and GLUT1 expression levels measured?",{"text":117,"@type":113},"Expression levels were measured in tissues using quantitative reverse transcriptase polymerase chain reaction (RT-PCR) and reported as fold change, followed by one-way ANOVA to test group differences.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the results show about miRNA10a and GLUT1?",{"text":121,"@type":113},"RT-PCR indicated increased miRNA10a and GLUT1 expression in OSCC compared with precancerous and healthy tissue, with a positive correlation between miRNA10a and GLUT1 expression levels.",{"name":123,"@type":110,"acceptedAnswer":124},"Why are miRNA10a and GLUT1 considered potentially important therapeutically?",{"text":125,"@type":113},"Upregulated miRNA10a was suggested to correlate with OSCC proliferation via GLUT1 overexpression, particularly under hyperglycemic conditions, supporting their potential as therapeutic targets in cancer management.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},326852,1790852499,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Open Access Original  \nArticle DOI: 10.7759/cureus.51752  \nReceived 10/20/2023  \nReview began 12/08/2023  \nReview ended 12/26/2023  \nPublished 01/06/2024  \n© Copyright 2024  \nR et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nThe Association of miRNA10a and Glucose Transporters in Oral Squamous Cell Carcinoma With Diabetes: A Pilot Study  \nSukanth R 1 , Priyadharshini R Jr. 2 , Selvaraj Jayaraman 3 , Sinduja Palati 2  \n1. Department of General Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND 2. Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND  \n3. Centre of Molecular Medicine and Diagnostics, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND  \nCorresponding author: Priyadharshini R Jr., [priyadharshinir.sdc@saveetha.com](priyadharshinir.sdc@saveetha.com)  \nAbstract  \nIntroduction: MicroRNAs (miRNAs) are well-established post-translational non-coding RNAs that play crucial roles in mRNA degradation and repression. Glucose transporter 1 (GLUT1) showed correlation along with various miRNA, specifically miRNA10a expression in lung cancers. The role of miRNA10a along with glucose upregulation leading to cancer proliferation in oral squamous cell carcinoma (OSCC) is unknown. This study aimed to investigate the expression levels of miRNA10a and GLUT1 in OSCC patients with diabetes.  \nMaterials and methods: miRNA10a and GLUT1 expression were estimated in OSCC, precancerous, and healthy tissues using quantitative reverse transcriptase polymerase chain reaction (RT-PCR) . miRNA10a and GLUT1 expression levels were recorded as fold change. Further, a one-way analysis of variance (ANOVA) test was performed to find whether there is any difference in miRNA10a and GLUT1 expression between OSCC, precancerous, and healthy tissues.  \nResults: The RT-PCR findings revealed an increased expression of miRNA10a and GLUT1 in OSCC compared to precancerous and healthy tissue. There is a positive correlation between miRNA10a and GLUT1 expression levels in both potentially malignant and control tissues, with a marked increase in cancerous tissue. This study demonstrated the significance of upregulated miRNA10a expression, indicating a direct correlation with OSCC proliferation via GLUT1 overexpression. Specifically, miRNA10a exhibited a fold change of 1 .2±0.072 in potentially malignant tissue and 1.4±0.05 in cancer tissue, while GLUT1 exhibited a fold change of 1 .25±0.092 in potentially malignant tissue and 0 .092±0.08 in cancer tissue, respectively.  \nConclusion: This research highlights the role of miRNA10a in cancer progression by facilitating proliferation through the regulation of GLUT1 in cancerous tissues, particularly in hyperglycemic conditions. This mechanism further contributes to increased glucose transport in cancer patients, which may potentially impede tumor prognosis. These findings underscore the potential significance of targeting miRNA10a and GLUT1 as therapeutic interventions in cancer management.  \nCategories: Pathology, Dentistry, Oncology  \nKeywords: expression, squamous cell carcinoma, mirna, innovative, glut  \nIntroduction  \nHead and neck cancer (HNC) represents a significant global health concern, with an estimated 888,000 new cases and 453,000 fatalities in 2018. Among these cases, oral squamous cell carcinoma (OSCC) stands out asthe seventh most prevalent cancer worldwide, ranking fifth among males and twelfth among females.  \nOSCC 's development is intricately linked to risk factors such as smoking, alco","cbCailBjzvAUswPS","https://ap.wps.com/l/cbCailBjzvAUswPS","pdf",227606,"English","# Abstract\n# Introduction\n## Head and neck cancer burden\n## OSCC risk factors and prognosis\n## Molecular metabolic pathways and GLUT1\n## miRNAs as biomarkers\n# Materials and methods\n# Results\n# Conclusion\n# References and citation","[{\"question\":\"What was the aim of this pilot study?\",\"answer\":\"To investigate the expression levels of miRNA10a and GLUT1 in OSCC patients with diabetes and to evaluate related differences across OSCC, precancerous, and healthy tissues.\"},{\"question\":\"How were miRNA10a and GLUT1 expression levels measured?\",\"answer\":\"Expression levels were measured in tissues using quantitative reverse transcriptase polymerase chain reaction (RT-PCR) and reported as fold change, followed by one-way ANOVA to test group differences.\"},{\"question\":\"What did the results show about miRNA10a and GLUT1?\",\"answer\":\"RT-PCR indicated increased miRNA10a and GLUT1 expression in OSCC compared with precancerous and healthy tissue, with a positive correlation between miRNA10a and GLUT1 expression levels.\"},{\"question\":\"Why are miRNA10a and GLUT1 considered potentially important therapeutically?\",\"answer\":\"Upregulated miRNA10a was suggested to correlate with OSCC proliferation via GLUT1 overexpression, particularly under hyperglycemic conditions, supporting their potential as therapeutic targets in cancer management.\"}]","The Association of miRNA10a and Glucose Transporters in Oral Squamous Cell Carcinoma With Diabetes: A Pilot Study | PDF",1789975559,18]