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A systematic search in PubMed, EMBASE, CENTRAL, and Web of Science (to May 1, 2023) included case-controls and cross-sectional studies measuring zinc status and/or intake, plus cohort evidence evaluating the association; studies without healthy controls were excluded and Joanna Briggs Institute criteria were used for quality assessment. Meta-analysis of 52 studies (163,909 participants) showed lower serum, hair, and prostatic zinc levels in patients, with limited publication bias, suggesting potential protective effects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-association-between-zinc-and-prostate-cancer-development-a-systematic-review-and-meta-analysis/330267/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-association-between-zinc-and-prostate-cancer-development-a-systematic-review-and-meta-analysis/330267.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about zinc and prostate cancer?","Question",{"text":112,"@type":113},"It evaluates whether zinc levels and/or zinc intake are associated with the development of prostate cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were studies selected and quality assessed?",{"text":117,"@type":113},"The authors searched PubMed, EMBASE, CENTRAL, and Web of Science up to May 1, 2023, included case-controls and cross-sectional studies plus cohorts with healthy controls, and used Joanna Briggs Institute for quality assessment.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the results show regarding zinc levels in prostate cancer patients?",{"text":121,"@type":113},"Serum, hair, and prostatic fluid or tissue zinc levels were significantly lower in prostate cancer patients, while nail zinc level and zinc intake showed no significant differences versus healthy controls.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330267,1790084731,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","PLOS ONE  \nOPEN ACCESS  \nCitation: Shahrokhi Nejad S, Golzari Z, Zangiabadian M, Salehi Amniyeh Khozani AA, Ebrahimi R, Nejadghaderi SA, et al. (2024) The association between zinc and prostate cancer development: A systematic review and metaanalysis. PLoS ONE 19(3): e0299398 . [https://doi](https://doi). org/10 .1371/journal.pone.0299398  \nEditor: Syed Amir Ashraf, University of Ha’il, SAUDI ARABIA  \nReceived: November 14, 2023  \nAccepted: February 9, 2024  \nPublished: March 20, 2024  \nCopyright: © 2024 Shahrokhi Nejad et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: All relevant data are within the manuscript and its Supporting Information files.  \nFunding: The author(s) received no specific funding for this work.  \nCompeting interests: The authors have declared that no competing interests exist.  \nRESEARCH ARTICLE  \nThe association between zinc and prostate cancer development: A systematic review and meta-analysis  \nShahrzad Shahrokhi Nejad1, Zahra Golzari1☯, Moein Zangiabadian2☯, Amir Abbas Salehi Amniyeh Khozani1☯, Rasoul Ebrahimi1☯, Seyed Aria Nejadghaderi1,3 *,  \nAzadeh Aletaha4,5 *  \n1 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 2 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran, 3 Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran, 4 Evidence Based Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, 5 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran  \n☯ These authors contributed equally to this work.  \n* [ariaghaderi@sbmu.ac.ir](ariaghaderi@sbmu.ac.ir), [ariang20@gmail.com](ariang20@gmail.com) (SAN); [azadeh.aletaha@gmail.com](azadeh.aletaha@gmail.com) (AA)  \nAbstract  \nBackground  \nProstate cancer is affecting males globally, with several complications. Zinc can play roles in cancers. We aimed to clarify the association between zinc levels or intake with prostate cancer development.  \nMethods  \nWe searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science until May 1, 2023. We included case-controls and cross-sectionals that measured zinc level and/or intake in patients with prostate cancer or cohorts that evaluated the association between zinc and prostate cancer development. Studies that did not have a healthy control group were excluded. Joanna Briggs Institute was used for quality assessment. Publication bias was evaluated using Egger’s and Begg’s tests and funnel plot.  \nResults  \nOverall, 52 studies (n = 44 case controls, n = 4 cohorts, and n = 4 cross sectionals) with a total number of 163909 participants were included. Serum (standardized mean difference (SMD): -1. 11; 95% confidence interval (CI): -1.67, -0.56), hair (SMD: -1.31; 95% CI: -2. 19,-0.44), and prostatic fluid or tissue zinc levels (SMD: -3.70; 95% CI: -4.90, -2.49) were significantly lower in prostate cancer patients. There were no significant differences in nail zinc level and zinc intake between those with prostate cancer and healthy controls. There was no publication bias except for serum and hair zinc levels based on Begg’s and Egger’s tests, respectively. The mean risk of bias scores were 4.61 in case-controls, eight in cohorts, and seven in cross-sectionals.  \nConclusions  \nOverall, high zinc levels might have a protective role in prostate cancer, which can be used as a therapeutic or preventive intervention. Future large-scale studies are needed to confirm the association","cbCaic2xMATsJRyz","https://ap.wps.com/l/cbCaic2xMATsJRyz","pdf",2188481,21,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What question does the study address about zinc and prostate cancer?\",\"answer\":\"It evaluates whether zinc levels and/or zinc intake are associated with the development of prostate cancer.\"},{\"question\":\"How were studies selected and quality assessed?\",\"answer\":\"The authors searched PubMed, EMBASE, CENTRAL, and Web of Science up to May 1, 2023, included case-controls and cross-sectional studies plus cohorts with healthy controls, and used Joanna Briggs Institute for quality assessment.\"},{\"question\":\"What did the results show regarding zinc levels in prostate cancer patients?\",\"answer\":\"Serum, hair, and prostatic fluid or tissue zinc levels were significantly lower in prostate cancer patients, while nail zinc level and zinc intake showed no significant differences versus healthy controls.\"}]","The association between zinc and prostate cancer development: A systematic review and meta-analysis | PDF",1789987947,53]