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This study examined paired tumor and matched non-cancerous tissues from 92 HNSCC patients, assessing NEAT1 expression by RT-qPCR and relating it to clinical features, treatment, and survival outcomes, including effects related to arecoline.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-association-between-the-expression-level-of-nuclear-paraspeckle-assembly-transcript-1-and-the-survival-rate-of-head-and-neck-cancer-patients-after-treatment/329040/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-association-between-the-expression-level-of-nuclear-paraspeckle-assembly-transcript-1-and-the-survival-rate-of-head-and-neck-cancer-patients-after-treatment/329040.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main objective regarding NEAT1 in HNSCC?","Question",{"text":112,"@type":113},"To investigate whether NEAT1 expression levels are associated with survival outcomes in HNSCC patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were NEAT1 levels measured in the study?",{"text":117,"@type":113},"NEAT1 expression was analyzed using RT-qPCR on paired tumor tissues and matched non-cancerous tissues.",{"name":119,"@type":110,"acceptedAnswer":120},"What relationship did the study find between NEAT1 expression and patient survival?",{"text":121,"@type":113},"Downregulated NEAT1 expression was linked to higher overall survival rates, with a more pronounced effect in patients who did not receive chemotherapy or radiotherapy, while upregulated NEAT1 suggested a worse prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329040,1790722145,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Journal of Dental Sciences 19 (2024) 2074e2081  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \nScienceDirect  \njournal [homepage:](homepage: www. e-jds. com)[ www. e-jds. com](homepage: www. e-jds. com)  \nOriginal Article  \nThe association between the expression level of nuclear paraspeckle assembly transcript 1 and the survival rate of head and neck cancer patients after treatment  \nNan-Chin Lin a,b,cy, Shih-Min Hsia dy, Thanh-Hien Vu Nguyen a, Tong-Hong Wang e, Kuo-Ting Sun a, Kuo-Chou Chiu f,g,  \nYin-Hwa Shih h** , Tzong-Ming Shieh a*  \na School of Dentistry, College of Dentistry, China Medical University, Taichung, Taiwan b Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, Changhua, Taiwan c Department of Oral and Maxillofacial Surgery, Show Chwan Memorial Hospital, Changhua, Taiwan d School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan  \ne Tissue Bank, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan f Division of General Dentistry, Taichung Armed Forces General Hospital, Taichung, Taiwan g School of Dentistry, National Defense Medical Center, Taipei, Taiwan  \nh Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan  \nReceived 19 March 2024; Final revision received 2 May 2024 Available online 26 May 2024  \nKEYWORDS  \nNuclear paraspeckle assembly transcript 1;  \nLong non-coding RNA;  \nHead and necksquamous cell carcinoma; Survival outcomes;  \nOral cancer  \nAbstract Background/purpose: The long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) exhibits diverse and complicated functions in cancer progression. Despite reports suggesting both tumor-suppressive and oncogenic effects in various cancers, its specific role in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study aimed to investigate the association between NEAT1 expression levels and survival outcomesin HNSCC patients.  \nMaterials and methods: Paired tissue samples of tumor and non-cancerous matching tissues (NCMT) from 92 HNSCC patients were collected. NEAT1 expression was analyzed using RTqPCR. Clinical characteristics, treatment received, and survival rates of the patients were assessed to determine the correlation with NEAT1 expression and explore its association with alcohol, betel quid, and cigarette use. Additionally, we examined the effect of arecoline on  \n* Corresponding author. School of Dentistry, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan.  \n** Corresponding author. Department of Healthcare Administration, Asia University, No.500, Lioufeng Rd. , Wufeng, Taichung 41354, Taiwan.  \nE-mail addresses: [evashih@asia.edu.tw](evashih@asia.edu.tw) (Y.-H. Shih), [tmshieh@mail.cmu.edu.tw](tmshieh@mail.cmu.edu.tw) (T.-M. Shieh).  \ny These two authors had equal contribution to this work.  \n[https://doi.org/10.1016/j.jds.2024.05.001](https://doi.org/10.1016/j.jds.2024.05.001)  \n1991-7902/ª 2024Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. This isan open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \nNEAT1 expression in normal human oral keratinocytes (NHOK) and fibroblasts (NHOF) . Results: The study revealed a significant downregulation of NEAT1 expression in oral cancer tissues compared to NCMT. Meanwhile, arecoline increased NEAT1 expression in NHOK and NHOF cells. However, patients with downregulated NEAT1 expression exhibited higher overall survival rates, particularly in those who did not receive chemotherapy or radiotherapy. Conclusion: NEAT1 expression levels are associated with survival outcomes in HNSCC patients, with upregulated expression indicating a worse prognosis, suggesting this lncRNA might contribute to cancer aggressiveness, especially in ","cbCaiavJjtkO8YCG","https://ap.wps.com/l/cbCaiavJjtkO8YCG","pdf",759067,"English","# Abstract\n## Background/purpose\n## Materials and methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the study’s main objective regarding NEAT1 in HNSCC?\",\"answer\":\"To investigate whether NEAT1 expression levels are associated with survival outcomes in HNSCC patients.\"},{\"question\":\"How were NEAT1 levels measured in the study?\",\"answer\":\"NEAT1 expression was analyzed using RT-qPCR on paired tumor tissues and matched non-cancerous tissues.\"},{\"question\":\"What relationship did the study find between NEAT1 expression and patient survival?\",\"answer\":\"Downregulated NEAT1 expression was linked to higher overall survival rates, with a more pronounced effect in patients who did not receive chemotherapy or radiotherapy, while upregulated NEAT1 suggested a worse prognosis.\"}]","The association between the expression level of nuclear paraspeckle assembly transcript 1 and the survival rate of head and neck cancer patients after treatment | PDF",1789982192]