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This cross-sectional analysis examines baseline associations between HBV/HCV and cancer outcomes within the Taiwan Biobank adult population, while adjusting for a broad set of confounders spanning sociodemographic factors, lifestyle variables, and comorbidities. Results test whether infection status corresponds to higher cancer likelihood and clarify interpretive limits for causality, recommending further genotype-based research.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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is the study’s main objective regarding HBV and HCV?","Question",{"text":63,"@type":64},"To explore associations between hepatitis B and C infections and cancer at baseline in the Taiwan Biobank adult population while controlling for multiple confounding variables.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the associations between viral infections and cancer evaluated?",{"text":68,"@type":64},"A cross-sectional comparison used chi-square tests for demographic, lifestyle, and comorbidity distributions, followed by univariate and multivariate logistic regression to estimate odds ratios and 95% confidence intervals with adjustments.",{"name":70,"@type":61,"acceptedAnswer":71},"Can the study establish causality between HBV/HCV and cancer?",{"text":72,"@type":64},"No. Because the design is cross-sectional, causal inferences cannot be made, and a recall-by-genotype study is recommended to further investigate 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24:20 [https://doi.org/10.1007/s10238-023-01292-x](https://doi.org/10.1007/s10238-023-01292-x)  \nThe association between hepatic viral infections and cancers: a cross‑sectional study in the Taiwan adult population  \nMoreen Maliko1 · Fu‑Hsiung Su2,3 · Abram Bunya Kamiza4,5 · Ming‑Jang Su1,6 · Chih‑Ching Yeh1,7,8,9  \nReceived: 4 October 2023 / Accepted: 28 December 2023 / Published online: 27 January 2024 © The Author(s) 2024  \nAbstract  \nBackground Hepatitis B (HBV) and hepatitis C (HCV) viruses are diseases of global public health concern and are associated with liver cancer. Recent studies have revealed associations between hepatic viral infections and extrahepatic cancers. This study aimed to explore the associations between hepatitis B and C viruses and cancer at baseline in the Taiwan Biobank database while controlling for a wide range of confounding variables.  \nMethods In a cross-sectional study of adults aged > 20 years, we compared the distribution of demographic factors, lifestyle, and comorbidities between viral and nonviral hepatic groups using the chi-square test. Univariate and multivariate logistic regressions were performed to observe the associations between hepatitis B and C viral infections and cancers by estimating the odds ratio (OR) and 95% confidence interval (CI) . Multivariate regression analysis was adjusted for sociodemographic factors, lifestyle, and comorbidities.  \nResults From the database, 2955 participants were identified as having HCV infection, 15,305 as having HBV infection, and 140,108 as the nonviral group. HBV infection was associated with an increased likelihood of liver cancer (adjusted OR (aOR) = 6.60, 95% CI = 3.21–13.57, P \u003C 0 .001) and ovarian cancer (aOR = 4.63, 95% CI = 1.98–10. 83, P = 0.001) . HCV infection was observed to increase the likelihood of liver cancer (aOR = 4.90, 95% CI = 1.37–17.53, P = 0.015), ovarian cancer (aOR = 8.50, 95% CI = 1.78–40.69, P = 0.007), and kidney cancer (aOR = 12.89, 95% CI = 2.41–69.01, P = 0.003) . Conclusion Our findings suggest that hepatic viral infections are associated with intra-and extrahepatic cancers. However, being cross-sectional, causal inferences cannot be made. A recall-by-genotype study is recommended to further investigate the causality of these associations.  \nKeywords Hepatitis B virus · Hepatitis C virus · Cancer · Adults · Cross-sectional study  \nAbbreviations  \naOR Adjusted odds ratio BMI Body mass index  \nCI Confidence interval  \n* Chih-Ching Yeh [ccyeh@tmu.edu.tw](ccyeh@tmu.edu.tw)  \n1 School of Public Health, College of Public Health, Taipei Medical University, 10F Biomedical Technology Building, No.301, Yuantong Rd., Zhonghe Dist., New Taipei City 235603, Taiwan  \n2 Department of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City, Taiwan  \n3 School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan  \n4 Faculty of Health Sciences, Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa  \nDNA Deoxyribonucleic acid  \nECLIA Electrochemiluminescence assay HBsAg Hepatitis B surface antigen HBV Hepatitis B virus  \n5 The African Computational Genomic (TACG) Research Group, MRC/UVRI and LSHTM, Entebbe, Uganda  \n6 Department of Clinical Pathology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, Taiwan  \n7 Department of Public Health, College of Public Health, China Medical University, Taichung 406, Taiwan  \n8 Cancer Center, Wan Fang Hospital, Taipei Medical University, New Taipei City 116, Taiwan  \n9 Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, New Taipei City 235603, Taiwan  \nHCV Hepatitis C virus  \nNHIRD National health insurance research database  \nNTD National Taiwan dollar  \nOR Odds ratio  \nRNA Ribonucleic acid  \nTWB Taiwan biobank  \nWHO World Health Organization  \nIntroduction  \nViral hepatiti","cbCaibHMjdhKbCui","https://ap.wps.com/l/cbCaibHMjdhKbCui","pdf",831330,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Keywords\n# Abbreviations\n# Introduction","[{\"question\":\"What is the study’s main objective regarding HBV and HCV?\",\"answer\":\"To explore associations between hepatitis B and C infections and cancer at baseline in the Taiwan Biobank adult population while controlling for multiple confounding variables.\"},{\"question\":\"How were the associations between viral infections and cancer evaluated?\",\"answer\":\"A cross-sectional comparison used chi-square tests for demographic, lifestyle, and comorbidity distributions, followed by univariate and multivariate logistic regression to estimate odds ratios and 95% confidence intervals with adjustments.\"},{\"question\":\"Can the study establish causality between HBV/HCV and cancer?\",\"answer\":\"No. Because the design is cross-sectional, causal inferences cannot be made, and a recall-by-genotype study is recommended to further investigate causality.\"}]","The association between hepatic viral infections and cancers: a cross-sectional study in the Taiwan adult population | PDF",1789995328,33]