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Neutrophil-to-lymphocyte ratio, derived NLR, monocyte-to-lymphocyte ratio, and hemoglobin-to-red cell distribution width ratio are analyzed alongside IL-6, IL-1β, IL-18, and TNF-α. Mendelian randomization integrates plasma proteome-wide GWAS with UK Biobank frailty genetics to infer causality, and GO/KEGG mapping clarifies mechanisms. Findings identify key predictors (notably NLR, dNLR, HRR) and inflammation-linked cytokines, highlighting JAK-STAT signaling as a driver connecting chronic inflammation to frailty and suggesting therapeutic targets.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-association-between-frailty-and-inflammatory-biomarkers-in-the-elderly-research-report/427509/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-association-between-frailty-and-inflammatory-biomarkers-in-the-elderly-research-report/427509.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-12","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which inflammatory markers were evaluated in relation to frailty?","Question",{"text":112,"@type":113},"The study assessed blood-derived indices (NLR, dNLR, MLR, HRR) from routine tests and quantified cytokines including IL-6, IL-1β, IL-18, and TNF-α.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What did the adjusted analyses identify as independent predictors of frailty?",{"text":117,"@type":113},"Adjusted analyses found NLR, dNLR, and HRR as independent frailty predictors, with elevated IL-6 and TNF-α also correlating with frailty.",{"name":119,"@type":110,"acceptedAnswer":120},"How was causality investigated in this study?",{"text":121,"@type":113},"Causality was evaluated using Mendelian randomization integrating plasma proteome-wide GWAS data with UK Biobank frailty genetics, then supported by functional pathway analyses using GO and KEGG.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427509,1790764738,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","852 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.2886  \nTHE ASSOCIATION BETWEEN FRAILTY AND INFLAMMATORY BIOMARKERS IN THE ELDERLY  \nXiaotian Shi, 1Qing Ma, 1Wen Tang, 1Shan Wang, 1 Huayu Yang, 1Deqiang Zhang, 1Yuanyuan Li1, and Ying Sun1, 1. Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing, China (People’s Republic)  \nObjectives: This study aims to characterize associations between frailty and systemic inflammation using blood-derived indices and cytokines, and identify causal mechanisms through proteogenomic integration. Methods: We analyzed neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), monocyte-to-lymphocyte ratio (MLR), and hemoglobin-to-red cell distribution width ratio (HRR) from routine blood tests. Serum interleukin-6 (IL-6), IL-1β, IL-18, and tumor necrosis factor-α (TNF-α) were quantified. Mendelian randomization (MR) integrated plasma proteome-wide genome-wide association study (GWAS) data (N =54,219) with UK Biobank frailty genetics (n=175,226) for causal inference. Functional annotation of differentially expressed proteins employed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Results: Adjusted analyses identified NLR (OR=1.57, 95%CI=1.07–2.30), dNLR (OR=1.59, 1.11–2.27), and HRR (OR=0.13, 0.03–0.44) as independent frailty predictors. Elevated IL-6 (OR= 1.14, 1.01–1.30) and TNF-α(OR=1.21, 1.07–1.36) correlated with frailty. MR revealed 26 plasma proteins causally linked to frailty, including five inflammation-associated proteins. Pathway analysis demonstrated JAK-STAT signaling enrichment, connecting chronic inflammation to frailty pathogenesis. Conclusions: NLR, dNLR and HRR serve as accessible frailty biomarkers, while IL-6 and TNF-α are cytokine drivers of frailty. The MR-validated plasma proteome implicates JAK-STAT axis activation as a key mechanism driving inflammation-associated frailty, providing therapeutic targets for this geriatric syndrome.","cbCaiurqLQKJLEaA","https://ap.wps.com/l/cbCaiurqLQKJLEaA","pdf",770026,"English","# Objectives\n## Methods\n## Results\n## Conclusions","[{\"question\":\"Which inflammatory markers were evaluated in relation to frailty?\",\"answer\":\"The study assessed blood-derived indices (NLR, dNLR, MLR, HRR) from routine tests and quantified cytokines including IL-6, IL-1β, IL-18, and TNF-α.\"},{\"question\":\"What did the adjusted analyses identify as independent predictors of frailty?\",\"answer\":\"Adjusted analyses found NLR, dNLR, and HRR as independent frailty predictors, with elevated IL-6 and TNF-α also correlating with frailty.\"},{\"question\":\"How was causality investigated in this study?\",\"answer\":\"Causality was evaluated using Mendelian randomization integrating plasma proteome-wide GWAS data with UK Biobank frailty genetics, then supported by functional pathway analyses using GO and KEGG.\"}]","THE ASSOCIATION BETWEEN FRAILTY AND INFLAMMATORY BIOMARKERS IN THE ELDERLY - Research report | PDF",1790644049]