[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-331762-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-331762-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-association-between-ephx1-gene-polymorphisms-and-lung-cancer-among-jordanian-people","The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People","","Genetic susceptibility to lung cancer is investigated through the microsomal epoxide hydrolase (EPHX1) gene. A case-control study screened 218 Jordanian participants (108 lung cancer patients and 110 matched controls) from Jordan University Hospital and King Hussein Cancer Center. Polymerase chain reaction–restriction fragment-length polymorphism (PCR-RFLP) identified two common EPHX1 polymorphisms in exons 3 and 4 (Tyr113His and His139Arg). No significant genotype differences emerged between patients and controls, or across age, gender, or tobacco consumption.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-association-between-ephx1-gene-polymorphisms-and-lung-cancer-among-jordanian-people/331762/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-association-between-ephx1-gene-polymorphisms-and-lung-cancer-among-jordanian-people/331762.png","ImageObject",300,407,{"name":42,"@type":43},"Ophelia","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study objective regarding EPHX1 and lung cancer?","Question",{"text":63,"@type":64},"To determine whether EPHX1 gene polymorphisms are linked to lung cancer susceptibility in Jordanian patients.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were EPHX1 polymorphisms detected in this case-control study?",{"text":68,"@type":64},"Polymerase chain reaction–restriction fragment-length polymorphism (PCR-RFLP) was used to detect two common polymorphisms located in exons 3 and 4 of EPHX1.",{"name":70,"@type":61,"acceptedAnswer":71},"Did EPHX1 polymorphisms show an association with lung cancer risk in the Jordanian population?",{"text":72,"@type":64},"No. The study found no significant genotype differences between patients and controls and concluded that common EPHX1 polymorphisms are not significant lung cancer risk factors in this population.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331762,1790832812,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","RESEARCH ARTICLE  \nEditorial Process: Submission:05/05/2024 Acceptance:11/14/2024  \nThe Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People  \nTamara E. Al-Qudah1, Said Ismail1, Dana Abdeen1, Nidaa A. Ababneh2, Faisal Khatib 1, Mohamed K. Al-Essa 1, Feras Hawari3, Nathir Obeidat4, Nabil J . Alkayed1,5 *, Yanal Shafagoj1  \nAbstract  \nObjective: Genetic susceptibility to lung cancer is the subject of extensive research. We investigated whether polymorphisms in the microsomal epoxide hydrolase (EPHX1) gene is linked to lung cancer susceptibility in Jordanian patients. Methods: In this case-control study a total of 218 subjects from Jordan University Hospital and King Hussein Cancer Center were screened (108 lung cancer patients and 110 matched controls). Polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) was used to detect the two common polymorphisms in EPXH1 located in exons 3 and 4; namely, amino acid substitution from tyrosine to histidine at residue 113 of exon 3 (Tyr113His; low activity allele) and amino acid substitution from histidine to arginine at residue 139 of exon 4 (His139Arg; high activity allele). Results: There was no significant difference in genotype distribution between control subjects and lung cancer patients. In addition, no differences were found when evaluated according to age, gender or tobacco consumption. For exon 3 the adjusted OR was 0.970 (95% CI 0.473-1.991) for the Tyr113/His113 genotype and 0.692 (95% CI 0.301 – 1.590) for the Tyr113/Tyr113 genotype, respectively. For exon 4 the adjusted OR was 0.596 (95% CI 0.297-1.197) for the His139/Arg139 genotype and 0.882 (95% CI 0.117-6.660) for theArg139/Arg139 genotype, respectively. Logistic regression analysis did not show differences in EPXH1 distributions between patients and controls when categorized according to predicted microsomal epoxide hydrolase activity. Therefore, common polymorphisms within EPHX1 do not appear to be significant risk factors for lung cancer development in the Jordanian population. Conclusion: No associations were observed between lung cancer risk and EPXH1 polymorphisms in the Jordanian population.  \nKeywords: EPXH1 polymorphism-Jordan-lung cancer-microsomal epoxide hydrolase  \nAsian Pac J Cancer Prev, 25 (11), 3913-3919  \nIntroduction  \nLung cancer represents a significant healthcare burden due to its high incidence and mortality rate. As reported by the GLOBOCAN 2020 database, it is the second most common type of cancer in the world, accounting for 11.4% of all new cancer cases, and has the highest mortality rate, accounting for 18.0% of total cancer deaths. In men, it is the leading cause of cancer morbidity and mortality, while in women, it ranks third in terms of incidence, preceded only by breast and colorectal cancer, and second in mortality, following breast cancer. In most countries, the survival of lung cancer patients at 5 years after diagnosis is only 10% to 20%; this high mortality rate is largely attributed to delayed diagnosis [1, 2] . According to the 23rd annual report of the incidence of cancer in Jordan  \npublished in 2018, lung cancer is the fourth most common type of cancer among the Jordanian population and the most common cause of cancer deaths in Jordanian males [3] .  \nVariuos risk factors have been identified, including active and passive tobacco smoking [4], genetic predisposition [5], and occupational exposure to certain chemicals and pollutants [6] . The most significant risk factor for the development of lung cancer is tobacco smoking, primarily due to the diverse carcinogenic agents present in the tobacco smoke, including polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. It is estimated that around 90% of lung cancer cases can be linked to the long-term inhalation of tobacco smoke [4, 5], nevertheless only 10%–20% of long-term smokers will ultimately develop lung cancer, which strongly suggests  \n1Department of Physiology and ","cbCaikD4hftxEVtB","https://ap.wps.com/l/cbCaikD4hftxEVtB","pdf",402937,"English","# Abstract\n# Introduction","[{\"question\":\"What was the study objective regarding EPHX1 and lung cancer?\",\"answer\":\"To determine whether EPHX1 gene polymorphisms are linked to lung cancer susceptibility in Jordanian patients.\"},{\"question\":\"How were EPHX1 polymorphisms detected in this case-control study?\",\"answer\":\"Polymerase chain reaction–restriction fragment-length polymorphism (PCR-RFLP) was used to detect two common polymorphisms located in exons 3 and 4 of EPHX1.\"},{\"question\":\"Did EPHX1 polymorphisms show an association with lung cancer risk in the Jordanian population?\",\"answer\":\"No. The study found no significant genotype differences between patients and controls and concluded that common EPHX1 polymorphisms are not significant lung cancer risk factors in this population.\"}]","The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People | PDF",1789995008,18]