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A large Norwegian cohort study analyzed associations between BMI and incident vulvar and vaginal cancers, using multivariable Cox regression to estimate hazard ratios and 95% confidence intervals. The analysis included 889,441 Norwegian women aged 16–75 at baseline from 1963–1975, followed for 30.1 million person-years. Results evaluated BMI categories and per-5 kg/m² increments, reporting subtype-specific and early-adulthood or early-onset effects, with implications for further mechanistic research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-association-between-body-mass-index-and-vulvar-and-vaginal-cancer-incidence-findings-from-a-large-norwegian-cohort-study/331725/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-association-between-body-mass-index-and-vulvar-and-vaginal-cancer-incidence-findings-from-a-large-norwegian-cohort-study/331725.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study designed to examine regarding BMI and these cancers?","Question",{"text":112,"@type":113},"The study assessed whether body mass index (BMI) is associated with the incidence of vulvar and vaginal cancer in a large cohort of Norwegian women.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many participants and person-years were included in the analysis?",{"text":117,"@type":113},"The dataset included 889,441 women aged 16–75 years at baseline, with follow-up totaling 30.1 million person-years.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the results suggest about BMI and cancer risk?",{"text":121,"@type":113},"Higher BMI was associated with increased risk of vulvar and vaginal cancers overall, with suggestive stronger associations for BMI in early adulthood and for early-onset vaginal cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331725,1790700800,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Cancer Causes & Control (2025) 36:191–198 [https://doi.org/10.1007/s10552-024-01930-z](https://doi.org/10.1007/s10552-024-01930-z)  \nThe association between body mass index and vulvar and vaginal cancer incidence: findings from a large Norwegian cohort study  \nDagfinn Aune1,2,3 · Marie Nordsletten4 · Tor Åge Myklebust5,6 · Trude Eid Robsahm1 · Bjørn Steen Skålhegg7 · Tom Mala4,8 · SherazYaqub4,8 · Usman Saeed4  \nReceived: 29 July 2024 / Accepted: 14 October 2024 / Published online: 27 October 2024 © The Author(s) 2024  \nAbstract  \nBackground There is limited evidence of potential associations between body mass index (BMI) and risk of vulvar and vaginal cancer. We explored these associations in a large cohort of Norwegian women.  \nMethods The analytical dataset included 889,441 women aged 16–75 years at baseline in 1963–1975. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between BMI and vulvar and vaginal cancer incidence.  \nResults During 30.1 million person-years of follow-up, 1748 incident vulvar and 408 incident vaginal cancer cases occurred. The HRs (95% CIs) for vulvar cancer for a BMI of 15- \u003C 18 .5, 18.5- \u003C 25, 25- \u003C 30, 30- \u003C 35, ≥ 35 were 0.62 (0 .38–1.01), 1.00 (reference), 1.23 (1 . 10–1.40), 1.43 (1 .23–1.66) and 1.72 (1 .35–2.20, ptrend \u003C 0 .001), and per 5 kg/m2 increment was 1.20 (1.13–1.26). The corresponding HRs (95% CIs) for vaginal cancer were 1.05 (0.52–2.15), 1.00, 0.89 (0.71–1.12), 0.95 (0 .68–1.34), and 2.01 (1 .29–3. 13, ptrend \u003C 0 .001), respectively, and per 5 kg/m2 was 1.11 (0 .99–1.25) . The HR (95% CI) per 5 kg/m2 increase in BMI at ages 16–29 was 1.28 (1 .07–1.54, n = 250 cases) for vulvar and 1.53 (1 .11–2. 11, n = 66 cases) for vaginal cancers. The HR (95% CI) per 5 kg/m2 for early-onset (\u003C 50 years age at diagnosis) vulvar cancer was 0.92 (0 .66–1.28, n = 87 cases) and 1.70 (1.05–2.76, n = 21 cases) for vaginal cancer.  \nConclusion These results further support the associations between higher BMI and increased risk of vulvar and vaginal cancers, with suggestive stronger associations between BMI in early adulthood for both cancers and for early-onset vaginal cancer. Further studies are needed to elucidate these findings and investigate the underlying mechanisms.  \nKeywords Body mass index · Vulvar cancer · Vaginal cancer · Cohort  \nIntroduction  \nVulvar and vaginal cancers are rare with an overall incidence rate globally of 0.9 cases per 100,000 person-years and 0.4 cases per 100,000 person-years, respectively, and a total of  \n* Dagfinn Aune[d.aune@imperial.ac.uk](d.aune@imperial.ac.uk)  \n1 Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway  \n2 Department of Nutrition, Oslo New University College, Oslo, Norway  \n3 Department of Epidemiology and Biostatistics, School of Public Health, White City Campus, 90 Wood Lane, London W12 0BZ, UK  \n4 Department of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway  \n45,000 and 18,000 cases occurred globally in 2020 [1] . Risk factors include human papilloma virus (HPV) infection [2, 3], sexual habits [2–4], various pre-cancerous lesions [3, 5], genital warts [2–4, 6–8], vulvar lichen sclerosis [3], conditions associated with immunosuppression such as HIV [3],  \n5 Department of Registration, Cancer Registry of Norway,  \nNorwegian Institute of Public Health, Oslo, Norway  \n6 Department of Research and Innovation, Møre and Romsdal Hospital Trust, Ålesund, Norway  \n7 Division for Molecular Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway  \n8 Institute for Clinical Medicine, University of Oslo, Oslo, Norway  \nsystemic lupus erythematosus [9] and organ transplantation [3, 10, 11], diethylstilbestrol use [12], alcoholism [13] and smoking [2, 4, 14] .  \nExcess weight is a risk factor for 12 cancers according to the World Cancer Research Fund [15], however, limited d","cbCaia2nHGYDtINb","https://ap.wps.com/l/cbCaia2nHGYDtINb","pdf",619840,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods","[{\"question\":\"What was the study designed to examine regarding BMI and these cancers?\",\"answer\":\"The study assessed whether body mass index (BMI) is associated with the incidence of vulvar and vaginal cancer in a large cohort of Norwegian women.\"},{\"question\":\"How many participants and person-years were included in the analysis?\",\"answer\":\"The dataset included 889,441 women aged 16–75 years at baseline, with follow-up totaling 30.1 million person-years.\"},{\"question\":\"What did the results suggest about BMI and cancer risk?\",\"answer\":\"Higher BMI was associated with increased risk of vulvar and vaginal cancers overall, with suggestive stronger associations for BMI in early adulthood and for early-onset vaginal cancer.\"}]","The association between body mass index and vulvar and vaginal cancer incidence: findings from a large Norwegian cohort study | PDF",1789994887]