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From 2549 records, 25 studies were included, mapping curcumin effects across prostate, ovarian, cervical, bladder, and renal cancers.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-association-between-anti-neoplastic-effects-of-curcumin-and-urogenital-cancers-a-systematic-review/329190/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-association-between-anti-neoplastic-effects-of-curcumin-and-urogenital-cancers-a-systematic-review/329190.png","ImageObject",300,407,{"name":42,"@type":43},"Sage","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study’s primary aim regarding curcumin and urogenital cancers?","Question",{"text":63,"@type":64},"To systematically review the anti-neoplastic effects of curcumin on urogenital cancers by assessing how curcumin regulates different microRNA expressions.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which studies were included and which were excluded in the systematic review?",{"text":68,"@type":64},"Included were English in vitro and observational studies evaluating curcumin’s prevention or treatment of urogenital cancers via microRNA expression. Excluded were in vivo or in silico studies.",{"name":70,"@type":61,"acceptedAnswer":71},"How did curcumin influence cell behavior according to the review’s conclusion?",{"text":72,"@type":64},"Curcumin inhibited cell proliferation and induced apoptosis in different urogenital cancers by suppressing oncogenic microRNAs or provoking tumor suppressor microRNAs.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},329190,1790088055,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Wiley  \nBioMed Research International  \nVolume 2024, Article ID 9347381, 11 pages [https://doi.org/10.1155/2024/9347381](https://doi.org/10.1155/2024/9347381)  \nReview Article  \nThe Association Between Anti-Neoplastic Effects of Curcumin and Urogenital Cancers: A Systematic Review  \nSadegh Mazaheri-Tehrani , 1,2 Shiva Rouzbahani ,3 and Motahar Heidari-Beni 4 1Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of NonCommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran  \n2Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran  \n3Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA  \n4Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of NonCommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran  \nCorrespondence should be addressed to Motahar Heidari-Beni; [heidari.motahar@gmail.com](heidari.motahar@gmail.com)  \nReceived 15 April 2024; Revised 24 September 2024; Accepted 4 October 2024  \nAcademic Editor: Cristiano Capurso  \nCopyright © 2024 Sadegh Mazaheri-Tehrani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nBackground: Curcumin is a polyphenol compound with anticancer effects. We aimed to review the anti-neoplastic effects ofcurcumin on urogenital cancers, by regulating different microRNA expressions.  \nMethods: A systematic search was conducted in Medline (PubMed), Embase, Scopus, and Web of Science up to the end of August  \n2024. All English, in vitro, and observational studies that evaluated the effect of curcumin on preventing or treating urogenital cancers through its impact on microRNA expression were included. In vivo or silico studies were excluded.  \nResult: A total of 2549 records were found. Finally, 25 studies were included. Twelve studies assessed the effect of curcumin on prostate cancer, six studies on ovarian cancer, three studies on cervical cancer, three studies on bladder cancer, and one study on renal cancer. MicroRNAs are small noncoding RNAs that regulate the post-transcriptional pathways. They possess pivotal roles in different fundamental mechanisms in cells such as differentiation, migration, apoptosis, and proliferation. Curcumin exerts its anticancer effects on urogenital neoplasms by upregulating tumor suppressor microRNAs (miR-143, miR-145, miRLet-7, miR-101, miR-3127, miR-3178, miR-1275, miR-3198, miR-1908, miR-770, miR-1247, miR-411, miR-34a, miR-383, miR- 708, miR-483, miR-199a, miR-335, miR-503, miR-10b, miR-551a, miR-9, miR-203, miR-7110, miR-29b, and miR-126) and downregulating oncogenic microRNAs (miR-21, miR-210, miR-382, miR-654, miR-494, miR-193b, miR-671, miR-222, miR- 23b, miR-664, miR-183, miR-214, miR-320a, miR-23a, miR-30a, miR-320d, miR-1285, miR-32, miR-181a, miR-205, miR-216a, miR-1246, and miR-106b) .  \nConclusion: Cell proliferation is inhibited, and cell apoptosis is induced by curcumin in different urogenital cancers through suppressing oncogenic microRNAs or provoking tumor suppressor microRNAs.  \nKeywords: curcumin; microRNAs; neoplasms; urogenital neoplasms  \n1. Introduction  \nProstate, bladder, kidney, testis, ovary, uterus, and cervix cancers are the most common types of urogenital neoplasms [1] . Based on global cancer statistics, approximately 20.3% of all cancers and 14.7% of all deaths due to malignancies are related to urogenital cancers [2] . Primary prevention, early  \ndiagnosis, and reducing exposure to carcinogens decrease mortality due to cancer. [3, 4] .  \nGenetic and epigenetic alterations can affect cancer initiation and progression through activation of oncogenic genes or inactivation of tumor suppressor genes [5] . Findings have shown some beneficial effe","cbCaigD7sIIWgy43","https://ap.wps.com/l/cbCaigD7sIIWgy43","pdf",939816,11,"English","# Background\n# Methods\n# Results\n## Disease-specific findings\n# Conclusion\n# Introduction\n# Materials and Methods","[{\"question\":\"What was the study’s primary aim regarding curcumin and urogenital cancers?\",\"answer\":\"To systematically review the anti-neoplastic effects of curcumin on urogenital cancers by assessing how curcumin regulates different microRNA expressions.\"},{\"question\":\"Which studies were included and which were excluded in the systematic review?\",\"answer\":\"Included were English in vitro and observational studies evaluating curcumin’s prevention or treatment of urogenital cancers via microRNA expression. Excluded were in vivo or in silico studies.\"},{\"question\":\"How did curcumin influence cell behavior according to the review’s conclusion?\",\"answer\":\"Curcumin inhibited cell proliferation and induced apoptosis in different urogenital cancers by suppressing oncogenic microRNAs or provoking tumor suppressor microRNAs.\"}]","The Association Between Anti-Neoplastic Effects of Curcumin and Urogenital Cancers - A Systematic Review | PDF",1789982993,28]