[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-349266-105":59,"doc-detail-349266-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-association-between-activity-patterns-and-malignant-neoplasms-of-female-genital-organs-a-prospective-cohort-study-of-uk-biobank","The association between activity patterns and malignant neoplasms of female genital organs: a prospective cohort study of UK biobank","","Objective: Clarify how the timing of physical activity influences the development and progression of malignant neoplasms of the female reproductive system. Methods: Using UK Biobank accelerometer data (49,540 women), participants were grouped by the timing of moderate-to-vigorous physical activity (morning, evening, mixed-time, midday-afternoon) and analyzed with Cox proportional hazards models per STROBE. Results: Over a median 12.6-year follow-up, evening and mixed-time patterns showed higher risks versus morning. Conclusions: MVPA timing during evening or mixed periods was linked to increased risk, while midday-afternoon showed no effect.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-association-between-activity-patterns-and-malignant-neoplasms-of-female-genital-organs-a-prospective-cohort-study-of-uk-biobank/349266/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-association-between-activity-patterns-and-malignant-neoplasms-of-female-genital-organs-a-prospective-cohort-study-of-uk-biobank/349266.png","ImageObject",300,407,{"name":92,"@type":93},"supergirl","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study objective regarding physical activity timing?","Question",{"text":112,"@type":113},"To investigate how patterns of physical activity timing relate to the risk of malignant neoplasms in the female reproductive system.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants categorized in this study?",{"text":117,"@type":113},"Based on when moderate-to-vigorous physical activity occurred during the day: morning, evening, mixed-time, and midday-afternoon, with morning as the reference group.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings on cancer risk by activity timing?",{"text":121,"@type":113},"After adjustment, evening and mixed-time groups had significantly higher hazards of malignant genital-organ neoplasms compared with morning, while no association was observed in the midday-afternoon group.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},349266,1790760558,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962088121634,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","TYPE Original Research PUBLISHED 25 May 2026  \nDOI 10.3389/fendo.2026.1845878  \nOPEN ACCESS  \nEDITED BY  \nBasilio Pecorino,  \nKore University of Enna, Italy  \nREVIEWED BY  \nGabriele Mazza, Umberto I Hospital, Italy Giorgio Arcarese,  \nKore University of Enna, Italy  \n*CORRESPONDENCE  \nDandan Zhang  \n[dandanzhang@hrbmu.edu.cn](dandanzhang@hrbmu.edu.cn)[ ](dandanzhang@hrbmu.edu.cn)Tianshu Han  \n [102403@hrbmu.edu.cn](102403@hrbmu.edu.cn)[ ](102403@hrbmu.edu.cn)†These authors have contributed equally to this work and share first authorship  \nRECEIVED 02 April 2026  \nREVISED 21 April 2026  \nACCEPTED 11 May 2026  \nPUBLISHED 25 May 2026  \nCITATION  \nLi X, Yu H, Teng Y, Guo H, Liu Y, Zhang D and Han T (2026) The association between activity patterns and malignant neoplasms of female genital organs: a prospective cohort study of UK biobank.  \nFront. Endocrinol. 17:1845878 .  \ndoi: 10.3389/fendo.2026.1845878  \nCOPYRIGHT  \n© 2026 Li, Yu, Teng, Guo, Liu, Zhang and Han. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nThe association between activity patterns and malignant neoplasms of female genital organs: a prospective cohort study of UK biobank  \nXuebing Li 1†, Hang Yu 1†, Yubing Teng 1, Huanyu Guo 1, Yuqing Liu 1, Dandan Zhang 1* and Tianshu Han 2*  \n1The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, 2 Harbin Medical University, Harbin, Heilongjiang, China  \nObjective: The role of physical activity timing in the development and progression of malignant neoplasms of the female reproductive system remains to be elucidated. Malignant neoplasms of female genital organs include those of the vulva, vagina, cervix, uterine corpus, uterus (part unspecified, site not further defined), ovaries, placenta, and other unspecified sites. This study aimed to investigate the association between patterns of physical activity and the risk of malignant neoplasms of the female reproductive system.  \nMethods: This study was reported in accordance with the STROBE guidelines for observational cohort studies. This research has been conducted using the UK Biobank Resource under Application ID: 103547 . This study included 49,540 female participants with valid accelerometer data from the UK Biobank at baseline . Physical activity patterns were defined based on the timing of moderate-to-vigorous physical activity (MVPA) occurrence throughout the day. According to the timing of MVPA, participants were categorized into four groups: morning, evening, mixed-time, and midday-afternoon groups, with the morning group serving as the reference. Cox proportional hazards models were employed to analyze the association between physical activity patterns and the incidence of malignant neoplasms of female genital organs.  \nResults: During a median follow-up of 12 . 6 years, 419 incident cases of malignant neoplasms of female genital organs were recorded. After adjusting for potential confounding factors, compared to women who engaged in morning exercise, those in the evening and mixed-time groups exhibited a significantly higher risk of developing reproductive system malignancies (Evening group: hazard ratio [HR] = 1.530, 95% confidence interval [CI]: 1.006–2.326; Mixed-time group: HR = 1.406, 95% CI: 1 .026–1. 928; P for trend \u003C0 . 05) .  \nConclusions: Compared to the morning group, engaging in MVPA during the evening or at mixed times was associated with an elevated risk of malignant  \nFrontiers in Endocrinology 01 [frontiersin.org](frontiersin.org)  \nneoplasms of the female reproductive system. This association was not observed in the midday-af","cbCaihWYBO3OKN8o","https://ap.wps.com/l/cbCaihWYBO3OKN8o","pdf",877360,13,"English","# Objective\n# Methods\n# Results\n# Conclusions\n# Keywords\n# Introduction","[{\"question\":\"What was the study objective regarding physical activity timing?\",\"answer\":\"To investigate how patterns of physical activity timing relate to the risk of malignant neoplasms in the female reproductive system.\"},{\"question\":\"How were participants categorized in this study?\",\"answer\":\"Based on when moderate-to-vigorous physical activity occurred during the day: morning, evening, mixed-time, and midday-afternoon, with morning as the reference group.\"},{\"question\":\"What were the main findings on cancer risk by activity timing?\",\"answer\":\"After adjustment, evening and mixed-time groups had significantly higher hazards of malignant genital-organ neoplasms compared with morning, while no association was observed in the midday-afternoon group.\"}]","The association between activity patterns and malignant neoplasms of female genital organs: a prospective cohort study of UK biobank | PDF",1790082506,33]