[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331005-105":59,"doc-detail-331005-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","the-application-of-organoids-in-cancers-associated-with-pathogenic-infections","The application of organoids in cancers associated with pathogenic infections","","Cancers associated with pathogen infections are becoming key threats to human health worldwide, making it essential to clarify pathogen-driven carcinogenesis mechanisms. Mechanistic work has often depended on animal and 2D cell culture models, yet these approaches are inadequate for rapid modeling of diseases linked to new pathogens. Organoid models can reproduce structural and genetic features of target tissues in vitro, offering new platforms for studying pathogen-induced oncogenic pathways. This review focuses on four pathogen-associated cancers and discusses organoid limitations to optimize future models and therapies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/the-application-of-organoids-in-cancers-associated-with-pathogenic-infections/331005/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/the-application-of-organoids-in-cancers-associated-with-pathogenic-infections/331005.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are organoid models considered important for cancers linked to pathogenic infections?","Question",{"text":112,"@type":113},"Organoids can replicate structural and genetic characteristics of target tissues in vitro, enabling more effective study of pathogen-induced oncogenic mechanisms than animal models or 2D cultures.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which pathogen-associated cancer types are covered in the review?",{"text":117,"@type":113},"The review summarizes organoid applications in gastric cancer linked to Helicobacter pylori, liver cancer associated with HBV or HCV, colorectal cancer caused by Escherichia coli, and cervical cancer related to HPV.",{"name":119,"@type":110,"acceptedAnswer":120},"What limitations of organoid technology are addressed for future research?",{"text":121,"@type":113},"The review proposes several limitations of organoid technology and suggests optimizing organoid models to advance treatment strategies for cancers associated with pathogen infections.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331005,1790196553,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Clinical and Experimental Medicine (2024) 24:168 [https://doi.org/10.1007/s10238-024-01435-8](https://doi.org/10.1007/s10238-024-01435-8)  \nThe application of organoids in cancers associated with pathogenic infections  \nYuyu Zhang1,3,4,5 · Tao Liu1,2,3,4,5 · Wenting He1,2,3,4,5  \nReceived: 15 April 2024 / Accepted: 12 July 2024 / Published online: 25 July 2024 © The Author(s) 2024  \nAbstract  \nCancers associated with pathogen infections are gradually becoming important threats to human health globally, and it is of great significance to study the mechanisms of pathogen carcinogenesis. Current mechanistic studies rely on animal and two-dimensional (2D) cell culture models, but traditional methods have been proven insufficient for the rapid modeling of diseases caused by new pathogens. Therefore, research focus has shifted to organoid models, which can replicate the structural and genetic characteristics of the target tissues or organs in vitro, providing new platforms for the study of pathogen-induced oncogenic mechanisms. This review summarizes the application of organoid technology in the studies of four pathogenassociated cancers: gastric cancer linked to Helicobacter pylori, liver cancer associated with hepatitis B virus or hepatitis C virus, colorectal cancer caused by Escherichia coli, and cervical cancer related to human papillomavirus. This review also proposes several limitations of organoid technology to optimize organoid models and advance the treatment of cancer associated with pathogen infections in the future.  \nKeywords Organoids · H. pylori · E. coli · HBV · HPV · Cancers  \nIntroduction  \nIn recent years, cancer has emerged as one of the most prevalent diseases, which is seriously harmful to human health and is a leading cause of mortality worldwide. The factors that cause the occurrence and development of cancer are multifaceted, including external physical factors (electric radiation, ultraviolet rays), chemical factors (nitrosamines,  \n* Tao Liu [liut@lzu.edu.cn](liut@lzu.edu.cn)  \n* Wenting He[hewt@lzu.edu.cn](hewt@lzu.edu.cn)  \n1 Department of the Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China  \n2 Second Hospital of Lanzhou University, Lanzhou University, Lanzhou 730000, China  \n3 Gansu Provincial Key Laboratory of Environmental Oncology, Lanzhou 730030, China  \n4 Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University, Lanzhou 730030, China  \n5 Digestive System Tumor Translational Medicine Engineering Research Center of Gansu Province, Lanzhou 730030, China  \naflatoxins), poor lifestyle habits (smoking, drinking, staying up late), genetic factors (gene mutations or deletions), and pathogenic infections. Notably, cancers associated with pathogen infections are also gradually becoming important threats to human health globally, such as gastric cancer linked to Helicobacter pylori (H. pylori), liver cancer linked to hepatitis B virus (HBV) or hepatitis C virus (HCV), colorectal cancer associated with Escherichia coli (E. coli), and cervical cancer caused by human papillomavirus (HPV) . The global 2022 incidence and mortality rates of gastric, liver, colorectal, and cervical cancers, and prevalence rates of these four cancers over the five-year period from 2018 to 2022 are shown in Table 1(data were obtained from Global Cancer Observatory), which also includes the percentage of these four pathogen-associated cancers in relation to overall cancers.  \nClassically, pathogen infection studies utilized cancer cell lines or animal models, but both of which have their disadvantages. Standard transformed cancer cell lines often cannot reproduce the essential characteristics of their corresponding cells in vivo counterparts [5] . Similarly, animal models may not always provide a faithful representation of human disease on account of differences between species [5]. Moreover, pathogens typically exhibit a limited species  ","cbCaiuqvfJDqFugF","https://ap.wps.com/l/cbCaiuqvfJDqFugF","pdf",1418132,11,"English","# Abstract\n# Introduction\n## Epidemiology and cancer burden\n## Limitations of classical models\n## Advantages of organoids\n# Organoid sources and disease modeling","[{\"question\":\"Why are organoid models considered important for cancers linked to pathogenic infections?\",\"answer\":\"Organoids can replicate structural and genetic characteristics of target tissues in vitro, enabling more effective study of pathogen-induced oncogenic mechanisms than animal models or 2D cultures.\"},{\"question\":\"Which pathogen-associated cancer types are covered in the review?\",\"answer\":\"The review summarizes organoid applications in gastric cancer linked to Helicobacter pylori, liver cancer associated with HBV or HCV, colorectal cancer caused by Escherichia coli, and cervical cancer related to HPV.\"},{\"question\":\"What limitations of organoid technology are addressed for future research?\",\"answer\":\"The review proposes several limitations of organoid technology and suggests optimizing organoid models to advance treatment strategies for cancers associated with pathogen infections.\"}]","The application of organoids in cancers associated with pathogenic infections | PDF",1789991055,28]