[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-367100-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-367100-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-anticancer-perspective-of-tangeretin-a-small-review","The Anticancer Perspective of Tangeretin - A Small Review","","Cancer threatens human life and health, and plant-derived natural compounds have shown inhibitory effects against tumors. Tangeretin, a widely occurring citrus flavonoid, demonstrates anticancer activity by suppressing growth, proliferation, and metastasis. Mechanisms include modulation of JAK/STAT signaling, activation of caspase-3 pathways, and regulation of cancer cell cycles. Tangeretin can also synergize with chemotherapy agents such as cisplatin, reducing resistance and improving treatment effectiveness. This review summarizes tangeretin effects across multiple cancers.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-anticancer-perspective-of-tangeretin-a-small-review/367100/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-anticancer-perspective-of-tangeretin-a-small-review/367100.png","ImageObject",300,407,{"name":42,"@type":43},"Emma Wilson","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What anticancer effects does tangeretin have?","Question",{"text":63,"@type":64},"Tangeretin inhibits cancer cell growth, proliferation, and metastasis. It is described as regulating signaling pathways and the cell cycle of tumor cells.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does tangeretin exert its anticancer mechanisms?",{"text":68,"@type":64},"It is reported to act through JAK/STAT signaling and caspase-3 signal transduction, and to influence the cell cycle, including blockade in the G1/S phase.",{"name":70,"@type":61,"acceptedAnswer":71},"Does tangeretin work with chemotherapy drugs?",{"text":72,"@type":64},"Yes. The document states that tangeretin can work with other chemotherapy drugs such as cisplatin to reduce drug resistance and improve therapeutic outcomes.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},367100,1790359921,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":108},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Review  \nThe Anticancer Perspective of Tangeretin: A Small Review  \nYuan Xu 1, Xi Yan 2,*, Junpeng Zhuang 1 and Haijun Hao 1, *  \nAcademic Editor: Ricardo Calhelha  \nReceived: 28 November 2024  \nRevised: 29 December 2024  \nAccepted: 10 January 2025  \nPublished: 13 January 2025  \nCitation: Xu, Y.; Yan, X.; Zhuang, J.; Hao, H. The Anticancer Perspective of Tangeretin: A Small Review. Molecules  \n2025, 30, 300. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/molecules30020300](10.3390/molecules30020300)  \n[Copyright:](Copyright:) © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China; [2022160084@buct.edu.cn](2022160084@buct.edu.cn) (Y.X.); [zhuangjp@mail.buct.edu.cn](zhuangjp@mail.buct.edu.cn) (J.Z.)  \n2 College of Chemistry, Beijing Normal University, Beijing 100875, China  \n* [Correspondence: yanxi@bnu.edu.cn](Correspondence: yanxi@bnu.edu.cn) (X.Y.); [hjhao@mail.buct.edu.cn](hjhao@mail.buct.edu.cn) (H.H.)  \nAbstract: Cancer is an important disease that threatens human life and health. Many natural compounds from plants have been found to have a better inhibitory effect on cancer, and flavonoids are one of them. Tangeretin, a flavonoid, is widely present in a variety of citrus plants and has been shown to have a variety of biological activities that can inhibit tumor cells. Tangeretin can inhibit the growth, proliferation, and metastasis of cancer cells by acting on JAK/STAT (Janus Kinase/signal transducer and activator of transcription) and caspase-3 signal transduction and by regulating the cell cycle of tumor cells. Tangeretin can also work with other chemotherapy drugs, such as cisplatin, to reduce the drug resistance of cancer cells and improve the therapeutic effect of chemotherapy drugs. This review summarizes the effects of tangeretin on various cancers.  \nKeywords: flavonoids; tangeretin; biological activity; anticancer substance; chemotherapy; natural compounds  \n1. Introduction  \nCancer is an important disease that endangers human health. It is the second leading cause of death in the world, and it poses a huge challenge and burden to individuals, families, and even entire societies [1,2] . According to the Global Cancer Incidence and Death Statistics 2022, there were nearly 20 million new cases of cancer in 2022 and nearly 9.7 million deaths from cancer, and there are likely to be more new cases each year in the future [3] . Chemotherapy is an important means of cancer treatment [4], and new compounds have been found to have positive effects on cancer treatment, which may provide us with a new way to treat cancer.  \nPlants are important sources of natural drugs, and many natural compounds extracted from plants have good therapeutic effects on cancer, such as steroidal saponins [5] . Flavonoids are widely found in plants and are secondary metabolites of plants. They can exist as glycoside ligands or several derivatives of glycosylation, acetylation, methylation, and sulfation [6] . Flavonoids are also commonly found in vegetables and fruits in our daily diet [7–9] . Flavonoids are plant-derived polyphenolic compounds with a 15-carbon flavonoid skeleton of C6-C3-C6 with a benzene ring attached to the 2-position of benzopyran [10] . A wide variety of flavonoids have shown good biological activities in the treatment of cancer, such as genistein [11], quercetin [12–14], chalcone [15–17], and others.  \nTangeretin (5,6,7,8,4′ -pentamethoxy flavonoid) is an important flavonoid, and its structure is shown in Figure 1 [18] . Tangeretin is widely found in citrus plants, and its content can be determined using liquid chro","cbCaivsTPe3lazTz","https://ap.wps.com/l/cbCaivsTPe3lazTz","pdf",669671,16,"English","# Introduction\n## Cancer burden and need for new treatments\n## Flavonoids as natural polyphenols\n## Tangeretin occurrence and extraction\n# Biological activity and anticancer mechanisms\n## Cell cycle effects and signaling pathways\n## Interaction with chemotherapy and drug resistance","[{\"question\":\"What anticancer effects does tangeretin have?\",\"answer\":\"Tangeretin inhibits cancer cell growth, proliferation, and metastasis. It is described as regulating signaling pathways and the cell cycle of tumor cells.\"},{\"question\":\"How does tangeretin exert its anticancer mechanisms?\",\"answer\":\"It is reported to act through JAK/STAT signaling and caspase-3 signal transduction, and to influence the cell cycle, including blockade in the G1/S phase.\"},{\"question\":\"Does tangeretin work with chemotherapy drugs?\",\"answer\":\"Yes. The document states that tangeretin can work with other chemotherapy drugs such as cisplatin to reduce drug resistance and improve therapeutic outcomes.\"}]","The Anticancer Perspective of Tangeretin - A Small Review | PDF",1790169273]