[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-381457-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-381457-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","the-anticancer-effect-of-napabucasin-bbi608-a-natural-naphthoquinone","The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone","","Napabucasin (also known as BBI608) is a natural naphthoquinone identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo findings indicate significant anticancer effects across multiple cancer types. Napabucasin suppresses proliferation, induces apoptosis and cell-cycle arrest, and reduces metastasis and relapse. The main activity is linked to inhibition of cancer stemness via targeting STAT3 and related gene suppression, with additional reported molecular targets including NQO1 and TrxR1.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-anticancer-effect-of-napabucasin-bbi608-a-natural-naphthoquinone/381457/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-anticancer-effect-of-napabucasin-bbi608-a-natural-naphthoquinone/381457.png","ImageObject",300,407,{"name":42,"@type":43},"Angel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What anticancer effects does napabucasin show?","Question",{"text":63,"@type":64},"Napabucasin inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, suppresses metastasis and relapse, and can help overcome drug resistance.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which molecular pathway is mainly associated with napabucasin’s mechanism?",{"text":68,"@type":64},"Its anticancer activities mainly rely on inhibiting cancer stemness by targeting STAT3 and suppressing related genes.",{"name":70,"@type":61,"acceptedAnswer":71},"What other molecular targets besides STAT3 are reported for napabucasin?",{"text":72,"@type":64},"Reported additional targets include NQO1 (NAD(P)H:quinone oxidoreductase 1) and TrxR1 (thioredoxin reductase 1), which are discussed as part of its molecular mechanism.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},381457,1790794587,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":112},687207412472,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","molecules   \nReview  \nThe Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone  \nZeyang Shao 1, Heng Wang 1, Haiyan Ren 1, Yinxiang Sun 2,* and Xiuping Chen 1,3,4,5, *  \nCitation: Shao, Z.; Wang, H.; Ren, H.; Sun, Y.; Chen, X. The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone. Molecules 2023, 28, 5678. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/molecules28155678](10.3390/molecules28155678)  \nAcademic Editor: Claudiu  \nT. Supuran  \nReceived: 9 June 2023  \nRevised: 23 July 2023  \nAccepted: 24 July 2023  \nPublished: 27 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, China; [mc25501@umac.mo](mc25501@umac.mo) (Z.S.); [mc15347@umac.mo](mc15347@umac.mo) (H.W.); [mc15376@umac.mo](mc15376@umac.mo) (H.R.)  \n2 Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, China  \n3 Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao, China  \n4 MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao, China  \n5 GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Disease, Guangzhou Medical University, Guangzhou 511436, China  \n* Correspondence: [sunyinxiang_3@163.com](sunyinxiang_3@163.com) (Y.S.); [xpchen@um.edu.mo](xpchen@um.edu.mo) (X.C.)  \nAbstract: Napabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, and suppresses metastasis and relapse. Such anticancer activities of napabucasin mainly rely on the inhibition of cancer stemness by targeting signal transducer and activator of transcription 3 (STAT3) and its related gene inhibition. However, several novel molecular targets for napabucasin, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and thioredoxin reductase 1 (TrxR1), have been reported. Napabucasin represents a promising anticancer lead for multiple cancers. In this mini review, the anticancer potential and the molecular mechanism of napabucasin will be briefly highlighted.  \nKeywords: napabucasin; cancer; STAT3; NQO1  \n1. Introduction  \nCancer is one of the most lethal diseases in the world, with a high annual mortality rate. So far, it is the second leading cause of death in the United States [1], and it has surpassed smoking as the main cause of death in China [2] . Surgy, radiotherapy, and chemotherapy are included as the most common conventional management for most cancers. Despite the fact that novel therapeutics, such as immunotherapy, etc., have shown promising results in specific patients [3], chemotherapy, including targeted therapy, and the fight against cancer by using cytotoxic compounds, hormone drugs, biological response modifiers, etc. are the most basic clinical treatment options in many developing countries. Despite the various drugs available in the anticancer menu, their prescriptions are often limited by the side effects, and their efficacy is frequently compromised by the inevitably developed drug resistance. Therefore, the discovery of anticancer drugs with high efficacy and minimal toxicity is urgently needed.  \nNatural products isolated from plants, animals, minerals, and microorganisms are important sources for anticancer drug research and development. The huge number and","cbCairEHeWnJKlQf","https://ap.wps.com/l/cbCairEHeWnJKlQf","pdf",741946,12,"English","# Abstract\n# Keywords\n# 1. Introduction\n# 2. Anticancer Activity of Napabucasin\n## 2.1. Cell Proliferation Inhibition and Cell Death Induction","[{\"question\":\"What anticancer effects does napabucasin show?\",\"answer\":\"Napabucasin inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, suppresses metastasis and relapse, and can help overcome drug resistance.\"},{\"question\":\"Which molecular pathway is mainly associated with napabucasin’s mechanism?\",\"answer\":\"Its anticancer activities mainly rely on inhibiting cancer stemness by targeting STAT3 and suppressing related genes.\"},{\"question\":\"What other molecular targets besides STAT3 are reported for napabucasin?\",\"answer\":\"Reported additional targets include NQO1 (NAD(P)H:quinone oxidoreductase 1) and TrxR1 (thioredoxin reductase 1), which are discussed as part of its molecular mechanism.\"}]","The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone | PDF",1790245392]