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This review focuses on dietary terpenoids that show anticancer activity against both melanoma and non-melanoma skin cancers, supporting collective skin protection against tumor development.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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Non-Melanoma Skin Cancers  \nYe Eun Yoon 1,*, Young Jae Jung 1 and Sung-Joon Lee 2,3, *  \nCitation: Yoon, Y.E.; Jung, Y.J.; Lee, S.-J. The Anticancer Activities of Natural Terpenoids That Inhibit Both Melanoma and Non-Melanoma Skin Cancers. Int. J. Mol. Sci. 2024, 25, 4423 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms25084423  \nAcademic Editor: Philip W. Wertz  \nReceived: 8 February 2024  \nRevised: 12 April 2024  \nAccepted: 15 April 2024  \nPublished: 17 April 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Biotechnology, Graduate School of Life Sciences & Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02855, Republic of Korea; [lyjung51@korea.ac.kr](lyjung51@korea.ac.kr)  \n2 Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul 02855, Republic of Korea  \n3 Interdisciplinary Program in Precision Public Health, BK21 Four Institute of Precision Public Health, Korea University, Seoul 02846, Republic of Korea  \n* [Correspondence: yeeun916@korea.ac.kr](Correspondence: yeeun916@korea.ac.kr) (Y.E.Y.); [junelee@korea.ac.kr](junelee@korea.ac.kr) (S.-J.L.)  \nAbstract: The prevalence of two major types of skin cancer, melanoma and non-melanoma skin cancer, has been increasing worldwide. Skin cancer incidence is estimated to rise continuously over the next 20 years due to ozone depletion and an increased life expectancy. Chemotherapeutic agents could affect healthy cells, and thus may be toxic to them and cause numerous side effects or drug resistance. Phytochemicals that are naturally occurring in fruits, plants, and herbs are known to possess various bioactive properties, including anticancer properties. Although the effects of phytochemicals are relatively milder than chemotherapeutic agents, the long-term intake of phytochemicals may be effective and safe in preventing tumor development in humans. Diverse phytochemicals have shown anti-tumorigenic activities for either melanoma or non-melanoma skin cancer. In this review, we focused on summarizing recent research findings of the natural and dietary terpenoids (eucalyptol, eugenol, geraniol, linalool, and ursolic acid) that have anticancer activities for both melanoma and non-melanoma skin cancers. These terpenoids may be helpful to protect skin collectively to prevent tumorigenesis of both melanoma and nonmelanoma skin cancers.  \nKeywords: skin cancer; melanoma; non-melanoma skin cancer; natural terpenoids; phytochemicals  \n1. Introduction  \nSkin, constituting approximately 16% of body mass, serves as a physiochemical barrier against daily attacks such as scratches, wounds, and environmental stressors, like chemicals, pathogens, and ultraviolet (UV) radiation [1,2] . As skin occupies the largest area of the body and each layer of skin has its distinctive function, maintaining skin health is crucial. However, the skin cancer incidence is dramatically increasing due to increased UV exposure, environmental factors, hereditary risk elements, and enhanced surveillance leading to earlier recognition, and has become a problem worldwide [3] .  \nSkin cancers are mainly divided into the following two types: melanoma and nonmelanoma skin cancer (NMSC) . Melanoma is a cancer that arises from the melanocytes in the epidermis. Melanoma, particularly cutaneous malignant melanoma (CMM), is renowned as the most aggressive form of skin cancer, distinguished by its likelihood of metastasis and elevated mortality rates [4] . CMM is frequently detected on t","cbCaiebLb0yFvebb","https://ap.wps.com/l/cbCaiebLb0yFvebb","pdf",3266915,16,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"Why is skin cancer incidence increasing worldwide?\",\"answer\":\"The document attributes rising incidence to factors such as ozone depletion and increased life expectancy, alongside increased UV exposure and environmental and hereditary risks.\"},{\"question\":\"What limitations are associated with chemotherapeutic agents?\",\"answer\":\"Chemotherapeutic agents may affect healthy cells, causing toxic side effects and contributing to numerous side effects or drug resistance.\"},{\"question\":\"Which terpenoids does the review focus on for anticancer activity?\",\"answer\":\"The review highlights natural dietary terpenoids, including eucalyptol, eugenol, geraniol, linalool, and ursolic acid, with anticancer activities against both melanoma and non-melanoma skin cancers.\"}]","The Anticancer Activities of Natural Terpenoids That Inhibit Both Melanoma and Non-Melanoma Skin Cancers | PDF",1789989191]