[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-388135-105":3,"detail-sidebar-cat-0-en-105":85,"doc-detail-388135-en":135},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":78,"head_meta":80,"extra_data":82,"updated_unix":84},105,"en","the-ameliorative-effect-of-acetylsalicylic-acid-plus-ascorbic-acid-against-renal-injury-in-corn-syrup-fed-rats","The ameliorative effect of acetylsalicylic acid plus ascorbic acid against renal injury in corn syrup-fed rats","","Dietary corn syrup can trigger reactive oxygen species generation and inflammatory signaling that contribute to kidney damage in humans and experimental animals. This study evaluated whether the antioxidant properties of acetylsalicylic acid (ASA) and ascorbic acid (AA) ameliorate corn syrup (CS)-induced renal injury. Male Sprague–Dawley rats were assigned to control, CS, CS+ASA, CS+AA, and combined CS+ASA+AA groups, with biochemical, histopathological, and immunohistochemical assessments in blood and tissues. CS increased MDA and reduced catalase activity, while ASA, AA, and the combination reversed oxidative and tissue injury markers, reversing tubular and hemorrhagic alterations.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/the-ameliorative-effect-of-acetylsalicylic-acid-plus-ascorbic-acid-against-renal-injury-in-corn-syrup-fed-rats/388135/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/the-ameliorative-effect-of-acetylsalicylic-acid-plus-ascorbic-acid-against-renal-injury-in-corn-syrup-fed-rats/388135.png","ImageObject",300,407,{"name":42,"@type":43},"Emma Wilson","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",21,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What was the purpose of this study?","Question",{"text":63,"@type":64},"To assess the effects of ASA and AA antioxidant properties against corn syrup-induced kidney damage in rats.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the rats grouped for the experiment?",{"text":68,"@type":64},"Rats were divided into five groups: control (C), CS, CS+ASA, CS+AA, and CS+ASA+AA combination therapy.",{"name":70,"@type":61,"acceptedAnswer":71},"Which biomarkers and analyses were used to evaluate kidney injury?",{"text":72,"@type":64},"Biochemical assays, histopathological analysis, and immunohistochemical staining were performed on blood and tissue samples.",{"name":74,"@type":61,"acceptedAnswer":75},"Did antioxidant treatment improve the kidney damage caused by corn syrup?",{"text":76,"@type":64},"Yes. ASA, AA, and the combination reduced CS-associated oxidative stress markers and reversed histopathological changes.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},388135,1790456795,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,114,119,124,127,131],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},7,40,"healthcare",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},8,"Research & Report",30,"research-report",{"id":120,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":122,"slug":123},9,"Religion & Spirituality",20,"religion-spirituality",{"id":122,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":122,"slug":126},"World Cup","world-cup",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":128,"slug":130},10,"Lifestyle","lifestyle",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":101,"slug":134},19,"General","general",{"code":4,"msg":86,"data":136},{"doc_id":83,"user_id":137,"nickname":42,"user_avatar":138,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":120,"language":144,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":12,"update_tm":148,"read_time":149,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","MAE Vet Fak Derg, 7 (1): 26-33, 2022  \nDOI: 10.24880/maeuvfd.981913  \nResearch Article  \nThe ameliorative effect of acetylsalicylic acid plus ascorbic acid against renal injury in corn syrup-fed rats  \nSukriye Yesilot1, Halil Asci2, Meltem Ozgocmen3, Mustafa Saygin4, Ilkay Armagan3, Ekrem Cicek 1Department of Nursing, Bucak School of Health, Burdur Mehmet Akif Ersoy University, Burdur, TURKEY  \n2Medicine, Medical Device and Dermocosmetic Research and Application Laboratory (IDAL), Faculty of Medicine, Suleyman Demirel University, Isparta, TURKEY 3Department of Histology and Embryology, Faculty of Medicine, Suleyman Demirel University, Isparta, TURKEY  \n4Department of Physiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.  \nKey Words:  \nacetylsalicylic acid ascorbic acid corn syrup renal injury  \nReceived : 12.08.2021  \nAccepted : 19.10.2021  \nPublished Online : 29.04.2022  \nArticle Code : 981913  \nCorrespondence: S YESILOT  \n([syesilot@mehmetakif.edu.tr](syesilot@mehmetakif.edu.tr))  \nORCID  \nS YESILOT : 0000-0003-3354-8489  \nH ASCI : 0000-0002-1545-035X  \nM OZGOCMEN : 0000-0003-3190-4486  \nM SAYGIN : 0000-0003-4925-3503  \nI ARMAGAN : 0000-0002-8080-9429  \nE CICEK : 0000-0002-4954-3482  \nThis study’s histological result was presented as a poster at the 5th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels, 9-12 September 2014, Isparta/ Turkey.  \nABSTRACT  \nDietary consumption of commercially prepared (often through processing) corn syrup can activate reactive oxygen species and the inflammatory pathways observed in kidney damage in humans and experimental animals. The study sought to assess the effects of the antioxidant properties of acetylsalicylic (ASA) and ascorbic acid (AA) on corn syrup (CS)-induced kidney damage. The rats (male Sprague–Dawley) were classified into 5 groups as follows: control (C), CS, CS+ASA (ASA-10 mg/kg/day/po), CS+AA (AA- 200 mg/kg/day/po) and CS+ASA+AA (combination therapy with ASA and AA doses) . Biochemical, histopathological and immunohistochemical analyzes were performed on blood and tissue samples. The levels of malondialdehyde (MDA) were rised in the CS-fed rats compared to control (p\u003C0.001) and were reduced in the ASA, AA and ASA+AA treated groups (p≤0.001 for all) compared to the CS group. Thecatalase (CAT) activities were reduced in the CS-fed group (p≤0.001) compared to the control (p\u003C0.001) and significantly rised in ASA+AA-treated group (p\u003C0.001) compared to the CS-fed group. Significant histopathological changes including tubular vacuoler degeneration, tubular dilatation, cortical and medullar haemorrhage, mononuclear cell infiltration, and increased inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) staining were observed in the CS group. Combination theraphy reversed all these changes. The administration of ASA and AA for the treatment of kidney damage due to corn syrup consumption provides an ideal target for improving oxidative stress and potential therapeutic treatments.  \nINTRODUCTION  \nCorn syrups (CS) obtained by hydrolysis of corn starch with α-amylase and glycoamylase are commercially added to food and widely used in the preparation of packaged foods (1) . CS is an additional source of sugar for daily consumption in most western countries that is consumed in ready meals (2) . Since CS significantly replaces sucrose in processed foods, the amount of daily fructose consumption by humans has increased significantly (3) . Fructose is naturally found in the fruits and vegetables; however, it is added to many convenience foods such as sucrose (from sugar cane and sugar beet) and high fructose corn syrup (HFCS) . HFCS is a modified sweetener formed by mixing free fructose and free glucose at varying concentrations. Although fructose and glucose are similar molecules, fructose-derived intermediate metabolites in the liver cause lipogenesis as they cannot be controlled physiological","cbCaisT6cSZCmabS","https://ap.wps.com/l/cbCaisT6cSZCmabS","pdf",1702181,"English","# ABSTRACT\n# INTRODUCTION","[{\"question\":\"What was the purpose of this study?\",\"answer\":\"To assess the effects of ASA and AA antioxidant properties against corn syrup-induced kidney damage in rats.\"},{\"question\":\"How were the rats grouped for the experiment?\",\"answer\":\"Rats were divided into five groups: control (C), CS, CS+ASA, CS+AA, and CS+ASA+AA combination therapy.\"},{\"question\":\"Which biomarkers and analyses were used to evaluate kidney injury?\",\"answer\":\"Biochemical assays, histopathological analysis, and immunohistochemical staining were performed on blood and tissue samples.\"},{\"question\":\"Did antioxidant treatment improve the kidney damage caused by corn syrup?\",\"answer\":\"Yes. ASA, AA, and the combination reduced CS-associated oxidative stress markers and reversed histopathological changes.\"}]","The ameliorative effect of acetylsalicylic acid plus ascorbic acid against renal injury in corn syrup-fed rats | PDF",1790294162,23]