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Searching for biomarkers that predict CESC prognosis and enable molecular treatment targets is therefore critical. TGFA, a polypeptide growth factor with high affinity for EGFR, has limited evidence in CESC. This study uses clinical data analysis and bioinformatics to assess TGFA–CESC relationships. Results show high TGFA expression in CESC tissues and cells, and TGFA knockdown suppresses CESC cell proliferation, migration, and invasion while reducing IL and MMP family proteins, suggesting TGFA as a potential therapeutic target.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tgfa-expression-is-associated-with-poor-prognosis-and-promotes-the-development-of-cervical-cancer/383182/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tgfa-expression-is-associated-with-poor-prognosis-and-promotes-the-development-of-cervical-cancer/383182.png","ImageObject",300,407,{"name":92,"@type":93},"awa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the central focus of the study regarding TGFA and CESC?","Question",{"text":113,"@type":114},"The study investigates whether TGFA expression is associated with CESC occurrence/progression and patient prognosis, and whether TGFA can serve as a potential molecular treatment target.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What do the results show about TGFA expression in cervical cancer?",{"text":118,"@type":114},"TGFA is highly expressed in cervical cancer tissues and cells compared with normal cervix and precancerous lesions, according to the study’s reported analyses.",{"name":120,"@type":111,"acceptedAnswer":121},"How does TGFA knockdown affect CESC cell behavior?",{"text":122,"@type":114},"TGFA knockdown inhibits CESC cell proliferation, migration, and invasion, and after TGFA knockout the expression of IL-family and MMP-family proteins is significantly reduced.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},383182,1790539201,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":36},3985747858093,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","DOI: 10. 1111/jcmm.18086  \nOR I G I NAL ART I C L E  \nTGFA expression is associated with poor prognosis and promotes the development of cervical cancer  \nXiaoxuan Ma1  | Jingying Zheng2 | Kang He1 | Liangjia Wang2 | Zeyu Wang1  | Kai Wang1 | Zunlong Liu1 | Zhiqiang San1 | Lijing Zhao1  | Lisheng Wang1  \n1Department of Rehabilitation, School of Nursing, Jilin University, Changchun, China  \n2Department of Gynecology and Obstetrics, Second Hospital of Jilin University, Changchun, China  \nCorrespondence  \nLijing Zhao and Lisheng Wang, Department of Rehabilitation, School of Nursing, Jilin University, Changchun 130021, China.  \nEmail: [zhao_lj@jlu.edu.cn](zhao_lj@jlu.edu.cn) and [lishengwang@jlu.edu.cn](lishengwang@jlu.edu.cn)  \nFunding information  \nJilin Provincial Department of Science and Technology project, Grant/Award Number: 20210204200YY  \nAbstract  \nCervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the second most common cancers in women aged 20–39. While HPV screening can help with early detection of cervical cancer, many patients are already in the medium to late stages when they are identified. As a result, searching for novel biomarkers to predict CESC prognosis and propose molecular treatment targets is critical. TGFA is a polypeptide growth factor with a high affinity for the epidermal growth factor receptor. Several studies have shown that TGFA can improve cancer growth and progression, but data on its impact on the occurrence and advancement of CESC is limited. In this study, we used clinical data analysis and bioinformatics techniques to explore the relationship between TGFA and CESC. The results showed that TGFA was highly expressed in cervical cancer tissues and cells. TGFA knockdown can inhibit the proliferation, migration and invasion of cervical cancer cells. In addition, after TGFA knockout, the expression of IL family and MMP family proteins in CESC cell lines was significantly reduced. In conclusion, TGFA plays an important role in the occurrence and development of cervical cancer. Therefore, TGFA may become a new target for cervical cancer treatment.  \nK E Y WO R D S  \nbioinformatics, biomarker, cervical cancer, prognosis, TGFA  \n1 | INTRODUCTION  \nCervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the second-largest causes of cancer death in women aged 20–39years, according to Cancer Statistics 2022.1 High-risk human papillomavirus (HPV) infection remains a major risk factor for cervical cancer.2 At the moment, the HPV vaccine offers considerable protection against cervical cancer.3 However, a significant percentage of  \nwomen have passed the vaccination age and frequently lack access to the HPV vaccine in places with lower socioeconomic levels. This will lead to hundreds of thousands of deaths from cervical cancer in the future.4 As a result, discovering novel biomarkers to predict patient prognosis and suggest treatment targets is critical.  \nTransforming growth factor α (TGFA) belongs to the epidermal growth factor (EGF) family of polypeptide growth factors and has a high affinity with the epidermal growth factor receptor (EGFR) .5  \nXiaoxuan Ma and Jingying Zheng contributed equally to this work.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.  \nWhen combined, EGF receptor (EGFR) dimer and tyrosine kinase activities are activated, and then downstream signalling pathways such as RAS/Raf/MAPK and PI3K/AKT are activated to promote cell proliferation, invasion, inhibit apoptosis and promote angiogenesis.6–11 TGFA may be associated with a variety of diseases. Mutation of the TGFA gene may increase the incidence of non-syndromic stomatofacial fissure and","cbCaic83QcKcMh9P","https://ap.wps.com/l/cbCaic83QcKcMh9P","pdf",20968961,16,"English","# Abstract\n# Introduction\n# Methods and Materials\n## Preprocessing and Data Sources","[{\"question\":\"What is the central focus of the study regarding TGFA and CESC?\",\"answer\":\"The study investigates whether TGFA expression is associated with CESC occurrence/progression and patient prognosis, and whether TGFA can serve as a potential molecular treatment target.\"},{\"question\":\"What do the results show about TGFA expression in cervical cancer?\",\"answer\":\"TGFA is highly expressed in cervical cancer tissues and cells compared with normal cervix and precancerous lesions, according to the study’s reported analyses.\"},{\"question\":\"How does TGFA knockdown affect CESC cell behavior?\",\"answer\":\"TGFA knockdown inhibits CESC cell proliferation, migration, and invasion, and after TGFA knockout the expression of IL-family and MMP-family proteins is significantly reduced.\"}]","TGFA expression is associated with poor prognosis and promotes the development of cervical cancer | PDF",1790255049]