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Sixty-six single-tooth implants were restored with all-ceramic crowns in 65 patients and followed at prosthetic delivery and after 1, 3, 5, and 10 years. Peri-implant soft tissue parameters were recorded, while standardized radiographs assessed peri-implant bone loss over time. Statistical comparisons used linear mixed regression and Wilcoxon Signed Rank tests (p \u003C 0.05).",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ten-year-results-of-a-prospective-study-on-one-piece-zirconia-oral-implants-for-single-tooth-reconstruction/439731/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ten-year-results-of-a-prospective-study-on-one-piece-zirconia-oral-implants-for-single-tooth-reconstruction/439731.png","ImageObject",300,407,{"name":92,"@type":93},"Cipher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main objective of the 10-year prospective study?","Question",{"text":113,"@type":114},"To clinically and radiographically investigate the outcomes of a one-piece zirconia implant system for single-tooth replacement over a 10-year period.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How many patients and implants were included, and how long were they followed?",{"text":118,"@type":114},"Sixty-five patients received 66 single-tooth implants. Follow-ups were performed at delivery and after 1, 3, 5, and 10 years.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key findings on implant survival and bone loss after 10 years?",{"text":122,"@type":114},"Sixteen implants were lost, producing a cumulative survival rate of 73.3%. The average marginal bone loss of remaining implants was 1.09 mm, with advanced bone loss reported as frequent.",{"name":124,"@type":111,"acceptedAnswer":125},"Based on the study conclusions, should the implant be used routinely?",{"text":126,"@type":114},"No. Due to the high implant loss rate after 10 years and the high occurrence of advanced bone loss, the implant was not recommended for routine clinical use.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},439731,1790716428,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":144,"language":145,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":146,"faqs":147,"seo_title":148,"seo_description":67,"update_tm":149,"read_time":41,"preview_page_count":4},687208528416,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Clinical Oral Implants Research  \nORIGINAL ARTICLE  OPEN ACCESS   \nTen-Year Results of a Prospective Study on One-Piece Zirconia Oral Implants for Single-Tooth Reconstruction  \nRalf-Joachim Kohal1  | Agneta Lith2 | Futoshi Komine3  | Junichi Honda3 | Benedikt C. Spies1 | Felix Burkhardt1  | Kirstin Vach4  \n1Medical Center – University of Freiburg, Center for Dental Medicine, Department of Prosthetic Dentistry, Faculty of Medicine, University of Freiburg, Freiburg, Germany | 2Department of Oral and Maxillofacial Radiology, Institute of Odontology, Sahlgrenska Academy, Gothenburg University, Göteborg, Sweden | 3Department of Fixed Prosthodontics, Nihon University School of Dentistry, Chiyoda-Ku, Tokyo, Japan | 4Medical Center – University of  \nFreiburg, Institute of Medical Biometry and Statistics, Freiburg, Germany Correspondence: Ralf-Joachim Kohal ([ralf.kohal@uniklinik-freiburg.de](ralf.kohal@uniklinik-freiburg.de))  \nReceived: 12 May 2025 | Revised: 16 July 2025 | Accepted: 10 September 2025  \nKeywords: clinical investigation | fixed dental prosthesis | oral implant | prospective | zirconia implant  \nABSTRACT  \nObjectives: The intention of this 10-year prospective cohort investigation was to clinically and radiographically investigate the outcomes of a one-piece zirconia implant system for single-tooth replacement.  \nMaterials and Methods: A total of 65 patients received 66 single-tooth implants restored with all-ceramic crowns. Follow-up assessments were conducted at the time of prosthetic delivery, after 1, 3, 5, and 10 years. Peri-implant soft tissue parameters were evaluated. To assess peri-implant bone loss, standardized radiographs were taken at implant placement, prosthetic delivery, atthe 1-, 3-, 5-, and 10-year follow-ups. Statistical analysis was conducted using linear mixed regression models and Wilcoxon Signed Rank tests to compare differences over time and between groups (p \u003C 0.05) .  \nResults: Over the course of 10 years, 16 implants were lost, yielding a cumulative survival rate of 73.3% . Fifteen patients were lost to follow-up over the 10-year period. The average marginal bone loss of the remaining implants was 1.09 mm. Probing depth, attachment level, and bleeding showed an increase over time, while plaque index slightly decreased.  \nConclusions: Given the high implant loss rate after 10 years and the high occurrence of advanced bone loss observed in this study, the implant was not recommended for routine clinical use.  \n1 | Introduction  \nThe clinical use of zirconia implants has seen significant growth over the past decade (Mohseni et al. 2023) . They are often viewed as a complement to titanium implants (Kohaland Dennison 2020), which continue to be the gold standard in oral implantology (Sanz et al. 2019) . Reasons for choosing zirconia implants include patients' desire for metal-free restorations, potential hypersensitivity to titanium, or aesthetic concerns when titanium may not be suitable for certain cases (Sicilia et al. 2008; Tschernitschek et al. 2005) . Especially,  \ntitanium particles/ions released from corroding or weardebris-generating titanium implants have been shown to influence the immune environment of peri-implant tissues. In particular, they can induce macrophage activation and polarization, often shifting them toward a pro-inflammatory M1 phenotype. This activation leads to the release of cytokines such as TNF-α, IL-1β, and IL-6, which can impair osteoblastic differentiation and promote bone resorption. Moreover, Ti ions may cause oxidative stress and stimulate the NLRP3 inflammasome, which has been linked to chronic inflammation and peri-implant bone loss (Huang et al. 2024; Lee et al. 2013;  \n\n| In this manuscript zirconia refers to 3% mol yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP) . |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the orig","cbCaigcmuEIfX2hi","https://ap.wps.com/l/cbCaigcmuEIfX2hi","pdf",1063908,12,"English","# ABSTRACT\n## Objectives\n## Materials and Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the main objective of the 10-year prospective study?\",\"answer\":\"To clinically and radiographically investigate the outcomes of a one-piece zirconia implant system for single-tooth replacement over a 10-year period.\"},{\"question\":\"How many patients and implants were included, and how long were they followed?\",\"answer\":\"Sixty-five patients received 66 single-tooth implants. Follow-ups were performed at delivery and after 1, 3, 5, and 10 years.\"},{\"question\":\"What were the key findings on implant survival and bone loss after 10 years?\",\"answer\":\"Sixteen implants were lost, producing a cumulative survival rate of 73.3%. The average marginal bone loss of remaining implants was 1.09 mm, with advanced bone loss reported as frequent.\"},{\"question\":\"Based on the study conclusions, should the implant be used routinely?\",\"answer\":\"No. Due to the high implant loss rate after 10 years and the high occurrence of advanced bone loss, the implant was not recommended for routine clinical use.\"}]","Ten-Year Results of a Prospective Study on One-Piece Zirconia Oral Implants for Single-Tooth Reconstruction | PDF",1790690027]