[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426863-105":59,"doc-detail-426863-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","temporal-associations-between-t-cell-senescence-and-arterial-stiffness-in-middle-agedolder-adults","TEMPORAL ASSOCIATIONS BETWEEN T-CELL SENESCENCE AND ARTERIAL STIFFNESS IN MIDDLE-AGED/OLDER ADULTS","","Age-related arterial remodeling and load-dependent stiffening can be estimated using arterial pulse-wave velocity (PWV) and blood pressure, yet the timing between senescence-associated T-cells and arterial stiffness remains unclear. Using data from the 18-week VEGGIE randomized caloric restriction trial, baseline T-cell senescence gene expression (CD3+; p16INK4a, p21CIP1/WAF1, BCL2, BAK1) was related to ePWV-derived measures (S-ePWV and LD-ePWV) and 18-week changes with multivariable regression adjusted for key covariates.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/temporal-associations-between-t-cell-senescence-and-arterial-stiffness-in-middle-agedolder-adults/426863/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/temporal-associations-between-t-cell-senescence-and-arterial-stiffness-in-middle-agedolder-adults/426863.png","ImageObject",300,407,{"name":92,"@type":93},"jayni","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-12","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective regarding T-cell senescence and arterial stiffness?","Question",{"text":112,"@type":113},"To determine whether higher T-cell senescence precedes or follows higher arterial stiffness, evaluated via S-ePWV and LD-ePWV measures.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which dataset and design were used for the analysis?",{"text":117,"@type":113},"The analysis used data from the 18-week VEGGIE randomized, controlled caloric restriction weight-loss trial in middle-aged and older adults.",{"name":119,"@type":110,"acceptedAnswer":120},"Which baseline gene expression signals showed associations with arterial stiffness measures?",{"text":121,"@type":113},"Higher baseline p16 and p21 were nominally associated with increased T-ePWV, while higher baseline BAK1 was associated with increased S-ePWV.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426863,1790797177,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":142,"read_time":81},3985747859343,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","1090 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.3663  \nTEMPORAL ASSOCIATIONS BETWEEN T-CELL  \nSENESCENCE AND ARTERIAL STIFFNESS IN  \nMIDDLE-AGED /OLDER ADULTS  \nTheodore DeConne, Stephen Kritchevsky, Jamie Justice, and Jingzhong Ding, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States  \nAge-related structural arterial remodeling (S) and load-dependent (LD) arterial stiffening can be calculated using arterial pulse-wave velocity (PWV) and blood pressure. Senescence-associated T-cells are cross-sectionally associated with both S-PWV and LD-PWV; however, the temporality isn’t known. This analysis aimed to determine whether higher T-cellsenescence precedes or follows higher S-PWV and LD-PWV leveraging data from the VEGGIE trial. The VEGGIE trial was an 18-week randomized, controlled, caloric restriction weight-loss trial in middle-aged and older adults (age:57.6 ± 5.8 years, n = 58, systolic blood pressure=129±17mmHg at baseline) . PWV was estimated (ePWV) using mean arterial pressure and age at each timepoint with previously established reference values. S-ePWVand LD-ePWV were calculated from total ePWV (T-ePWV) using participant-specific exponential models. CD3+ T-cell senescence gene expression (p16INK4a, p21CIP1/WAF1, BCL2, and BAK1) was measured. Multivariable linear regressions tested associations between baseline T-cell senescence and arterial stiffness with 18-week change in PWV or T-cell senescence. Models were adjusted for biologic sex, BMI, race, and treatment-group. Higher baseline p16 (β = 0.546,P=0.0688) and p21 (β = 0.398,P=0.0593) were nominally associated with increased T-ePWV. Higher baseline BAK1 was associated with increased S-ePWV (β = 0.0987,P=0.037). A treatment-group-by-baseline p16 interaction effect was observed with delta T-ePWV (p=0.0234), where T-ePWV only increased in participants with high p16 at baseline in the caloric restriction group (β =1.16,P=0.00405). Interestingly, higher baseline T-ePWV (β=-0.329,P=0.0556) and S-ePWV (β=-0.378,P=0.048) were associated with decreased p21 . In conclusion, temporal associations between CD3+ senescence and arterial stiffness may be bi-directional and future research is needed directly measuring PWV andT-cell senescence over longer periods.","cbCaiiwmhP7v6vmn","https://ap.wps.com/l/cbCaiiwmhP7v6vmn","pdf",968336,"English","[{\"question\":\"What was the study’s main objective regarding T-cell senescence and arterial stiffness?\",\"answer\":\"To determine whether higher T-cell senescence precedes or follows higher arterial stiffness, evaluated via S-ePWV and LD-ePWV measures.\"},{\"question\":\"Which dataset and design were used for the analysis?\",\"answer\":\"The analysis used data from the 18-week VEGGIE randomized, controlled caloric restriction weight-loss trial in middle-aged and older adults.\"},{\"question\":\"Which baseline gene expression signals showed associations with arterial stiffness measures?\",\"answer\":\"Higher baseline p16 and p21 were nominally associated with increased T-ePWV, while higher baseline BAK1 was associated with increased S-ePWV.\"}]","TEMPORAL ASSOCIATIONS BETWEEN T-CELL SENESCENCE AND ARTERIAL STIFFNESS IN MIDDLE-AGED/OLDER ADULTS | PDF",1790642061]