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This study examines whether the Hippo pathway co-activator TAZ regulates gluconeogenesis and promotes tumorigenesis in HCC, and whether TAZ acts through the glucocorticoid receptor (GR). Using TCGA and clinical validation, cellular gain/loss of TAZ, gene expression profiling, in vivo tumor models, and mechanistic assays, results identify TAZ upregulation, altered gluconeogenic genes, and a TAZ–GR interaction that suppresses GR transcriptional activity.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/taz-ww-domain-mediated-regulation-of-gluconeogenesis-and-tumorigenesis-in-hepatocellular-carcinoma-through-interaction-with-the-glucocorticoid-receptor/349159/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/taz-ww-domain-mediated-regulation-of-gluconeogenesis-and-tumorigenesis-in-hepatocellular-carcinoma-through-interaction-with-the-glucocorticoid-receptor/349159.png","ImageObject",300,407,{"name":42,"@type":43},"Đào","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What problem does the study address in hepatocellular carcinoma?","Question",{"text":63,"@type":64},"It addresses poor outcomes in HCC by focusing on how tumor metabolism, particularly glucose metabolism, supports tumor survival and progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was TAZ involvement in HCC evaluated?",{"text":68,"@type":64},"TAZ expression was analyzed using TCGA data and validated in clinical samples and cell lines, then TAZ was overexpressed or silenced to test effects on proliferation, apoptosis, migration, and invasion.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the relationship between TAZ, gluconeogenesis genes, and tumor behavior?",{"text":72,"@type":64},"TAZ was significantly upregulated in HCC, and TAZ overexpression increased proliferation while decreasing apoptosis and promoting migration/invasion; gluconeogenesis genes PCK1 and G6PC were downregulated and negatively correlated with TAZ.",{"name":74,"@type":61,"acceptedAnswer":75},"How does TAZ influence the glucocorticoid receptor in this study?",{"text":76,"@type":64},"The study shows that TAZ interacts with the glucocorticoid receptor and suppresses its transcriptional activity on gluconeogenic gene promoters.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},349159,1790692785,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,109,113,118,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Technology",50,"technology",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":111,"slug":112},7,40,"healthcare",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},8,"Research & Report",30,"research-report",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},9,"Religion & Spirituality",20,"religion-spirituality",{"id":121,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":121,"slug":125},"World Cup","world-cup",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":127,"slug":129},10,"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":101,"slug":133},19,"General","general",{"code":4,"msg":86,"data":135},{"doc_id":83,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":110,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":143,"language":144,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":12,"update_tm":148,"read_time":149},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Original Article  \nEndocrinol Metab 2026;41:267-287 [https://doi.org/10.3803/EnM.2025.2471](https://doi.org/10.3803/EnM.2025.2471)[ ](https://doi.org/10.3803/EnM.2025.2471)[pISSN 2093-596X](pISSN 2093-596X) · eISSN 2093-5978  \nTAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor  \nHongxiang Huang1,2, Jinhong Chen1, Xingyu Tao3, Peiyuan Zhong1, Yanqiu Meng1, Sujuan Peng1, Wanying Luo3, Zhiyong He3, Shuai Luo3, Xie Zhu1, Zhihui Lu1, Li Chen1, Yangyang Liu1  \n1Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang; 2Department of Oncology, Ganzhou People’s Hospital, Ganzhou; 3Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China  \nBackground: Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, characterized by poor prognosis due to its high proliferative and invasive potential. Tumor metabolic reprogramming, particularly involving glucose metabolism, is essential for tumor survival. This study investigates the role of the Hippo pathway effector transcriptional co-activator with PDZ-binding motif (TAZ) in regulating gluconeogenesis and promoting tumorigenesis in HCC.  \nMethods: TAZ expression in HCC was analyzed using The Cancer Genome Atlas data and validated in clinical samples and cell lines. TAZ was overexpressed or silenced in HCC cell lines to evaluate its effects on cell proliferation, apoptosis, migration, and invasion. The expression and prognostic relevance of the gluconeogenesis-related genes phosphoenolpyruvate carboxykinase 1 (PCK1) and glucose-6-phosphatase (G6PC) were examined, along with their correlation with TAZ expression. Tumor growth was assessed in nude mice. Interactions between TAZ and the glucocorticoid receptor (GR) were investigated using co-immunoprecipitation, immunofluorescence, and chromatin immunoprecipitation assays.  \nResults: TAZ was significantly upregulated in HCC tissues and cell lines. TAZ overexpression enhanced proliferation, reduced apoptosis, and promoted migration and invasion. In contrast, PCK1 and G6PC were downregulated in HCC and showed a negative correlation with TAZ expression.  \nConclusion: TAZ modulates gluconeogenesis and accelerates tumor growth, whereas its knockdown attenuates tumor progression. TAZ interacts with GR, suppressing its transcriptional activity on gluconeogenic gene promoters.  \n\n| Keywords: Hepatocellular carcinoma; TAZ; Glucose metabolism; Gluconeogenesis genes; Receptors, glucocorticoid |  |\n| --- | --- |\n| Received: 22 May 2025, Revised: 1 September 2025, Accepted: 30 September 2025\u003Cbr>Corresponding authors: Li Chen\u003Cbr>Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.17, Yongwai Zhengjie, Donghu District, Nanchang City 330006, Jiangxi Province, China\u003Cbr>Tel: +86-13803515919, Fax: +86-0791-7068511, E-mail: [clmedic@126.com](clmedic@126.com)\u003Cbr>Yangyang Liu\u003Cbr>Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.17, Yongwai Zhengjie, Donghu District, Nanchang City 330006, Jiangxi Province, China\u003Cbr>Tel: +86-15927166267, Fax: +86-0791-7068511, E-mail: [liuyyeyhl@163.com](liuyyeyhl@163.com) | Copyright © 2026 Korean Endocrine Society\u003Cbr>This is an Open Access article distributed under the terms of\u003Cbr>the Creative Commons Attribution Non-Commercial License ([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.\u003Cbr>|\n\n[www.e-enm.org](www.e-enm.org) 267  \nHuang H, et al.  \nINTRODUCTION  \nHepatocellular carcinoma (HCC) is the most common type of primary liver cancer, ranking sixth in incidence and third in cancer-related m","cbCaiolhkWbKqF0w","https://ap.wps.com/l/cbCaiolhkWbKqF0w","pdf",3159353,21,"English","# Introduction\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What problem does the study address in hepatocellular carcinoma?\",\"answer\":\"It addresses poor outcomes in HCC by focusing on how tumor metabolism, particularly glucose metabolism, supports tumor survival and progression.\"},{\"question\":\"How was TAZ involvement in HCC evaluated?\",\"answer\":\"TAZ expression was analyzed using TCGA data and validated in clinical samples and cell lines, then TAZ was overexpressed or silenced to test effects on proliferation, apoptosis, migration, and invasion.\"},{\"question\":\"What is the relationship between TAZ, gluconeogenesis genes, and tumor behavior?\",\"answer\":\"TAZ was significantly upregulated in HCC, and TAZ overexpression increased proliferation while decreasing apoptosis and promoting migration/invasion; gluconeogenesis genes PCK1 and G6PC were downregulated and negatively correlated with TAZ.\"},{\"question\":\"How does TAZ influence the glucocorticoid receptor in this study?\",\"answer\":\"The study shows that TAZ interacts with the glucocorticoid receptor and suppresses its transcriptional activity on gluconeogenic gene promoters.\"}]","TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor | PDF",1790082013,53]