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Methods: TGP and SS protein targets were retrieved from databases, and the intersecting genes were identified. A drug-target network was built and analyzed with Cytoscape, followed by Gene Ontology and KEGG enrichment. Potential targets were further tested by molecular docking. Results: Forty-six overlapping genes supported TGP’s multitarget actions on apoptosis, oxidative stress response, and rhythmic processes. Conclusion: Key targets linked to 3372 proteins were proposed.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targets-of-total-glucosides-of-paeony-in-the-treatment-of-sjogren-syndrome-a-network-pharmacology-study/436735/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targets-of-total-glucosides-of-paeony-in-the-treatment-of-sjogren-syndrome-a-network-pharmacology-study/436735.png","ImageObject",300,407,{"name":92,"@type":93},"Angel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the goal of this study on TGP in Sjogren syndrome?","Question",{"text":112,"@type":113},"To explore the underlying mechanism of total glucoside of peony (TGP) in treating Sjogren syndrome (SS) using a network pharmacology approach.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were potential targets of TGP and SS identified and analyzed?",{"text":117,"@type":113},"Protein targets were obtained via database search, then intersecting targets between TGP and SS were identified. A drug-target network was constructed in Cytoscape, and Gene Ontology/KEGG enrichment was performed. Docking was used to evaluate predicted potential targets.",{"name":119,"@type":110,"acceptedAnswer":120},"What major biological processes and key targets were suggested by the results?",{"text":121,"@type":113},"The 46 overlapping genes indicated involvement of intrinsic apoptotic signaling, oxidative stress response, and other processes. Key targets included caspase 3 and VEGFA-related factors, associated with 3372 proteins.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436735,1790794660,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687207412472,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d",".  \nJ Chin MedAssoc  \nOriginal article  \nTargets of total glucosides of paeony in the treatment of Sjogren syndrome: A network pharmacology study  \nLu Xiaoa, Wei Xiaob, Feng Zhana,*  \naDepartment of Rheumatology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan, China; bDepartment of Respiratory, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan, China  \nAbstract  \nBackground: We aimed to explore the underlying mechanism of the total glucoside of peony (TGP) in treating Sjogren syndrome (SS) using the network pharmacology approach.  \nMethods: The protein targets of TGP and SS were identified by database search. Then, the intersection of the two groups was studied. The drug–target network between TGP and the overlapping genes was constructed, visualized, and analyzed by Cytoscape software. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment were performed to analyze these genes. Finally, the predictions of potential targets were evaluated by docking study.  \nResults: Forty-six overlapping genes were discovered. The results suggested that TGP used in the treatment of SS is associated with cellular tumor antigen p53, neurotrophic tyrosine kinase receptor type 1, and epidermal growth factor receptor, as well as their related 3372 protein networks, which regulate intrinsic apoptotic signaling pathway, cellular response to oxidative stress, rhythmic process, and other processes. Molecular docking analysis proved that hydrogen bonding is the main form of interaction. Conclusion: Our research provided the protein targets affected by TGP in SS treatment. The key targets (caspase 3, vascular endothelial growth factor A, glyceraldehyde-3-phosphate dehydrogenase, etc.), which involve 3372 proteins, are the multitarget mechanism of TGP in SS treatment.  \nKeywords: CASP3; Network pharmacology; Sjogren syndrome; Total glucosides of peony  \n1. INTRODUCTION  \nSjogren syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands.1 Recent epidemiological studies reported that SS is the second most common rheumatic disease in China with a mean annual incidence rate of 7.7 cases per 100,000 adults.2 The classical clinical manifestations of SS are dry mouth and dry eyes, as well as high levels of the ribonucleoproteins, Ro/SSA, and/or La/SSB.3 Current therapeutic regimens are focused on symptom relief and broad-spectrum immunosuppression. Recent advancementsin medicine and pharmacology have led to the development of more comprehensive, multistage SS therapies, and alternative medicine has become the patient’s choice. Traditional Chinese medicine (TCM) is the most frequently used alternative medicine in the prevention and control of SS in China because of its good therapeutic effect and low toxic side effect.  \n* Address correspondence. Dr. Feng Zhan, Department of Rheumatology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan, China. E-mail address: [renal@126.com](renal@126.com) (F. Zhan).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 375-380.  \nReceived August 26, 2021; accepted July 27, 2022.  \ndoi: 10. 1097/JCMA.0000000000000884.  \nCopyright © 2023, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nTotal glucoside of peony (TGP) is extracted from Radix Paeoniae Alba, which is considered an effective TCM for several diseases. TGP consists of several active ingredients, including paeoniflorin, albiflorin, and benzoylpaeoniflorin; among which, paeoniflorin accounts for more than 90%.4,5 TGP was approved as a disea","cbCaim6SbbXKyKtQ","https://ap.wps.com/l/cbCaim6SbbXKyKtQ","pdf",1026044,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# 1. Introduction","[{\"question\":\"What is the goal of this study on TGP in Sjogren syndrome?\",\"answer\":\"To explore the underlying mechanism of total glucoside of peony (TGP) in treating Sjogren syndrome (SS) using a network pharmacology approach.\"},{\"question\":\"How were potential targets of TGP and SS identified and analyzed?\",\"answer\":\"Protein targets were obtained via database search, then intersecting targets between TGP and SS were identified. A drug-target network was constructed in Cytoscape, and Gene Ontology/KEGG enrichment was performed. Docking was used to evaluate predicted potential targets.\"},{\"question\":\"What major biological processes and key targets were suggested by the results?\",\"answer\":\"The 46 overlapping genes indicated involvement of intrinsic apoptotic signaling, oxidative stress response, and other processes. Key targets included caspase 3 and VEGFA-related factors, associated with 3372 proteins.\"}]","Targets of total glucosides of paeony in the treatment of Sjogren syndrome - A network pharmacology study | PDF",1790678862,15]