[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-327641-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-327641-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","targeting-tumor-associated-macrophages-review","Targeting tumor-associated macrophages - Review","","Tumor-associated macrophages (TAMs) are essential tumor microenvironment components with marked phenotypic heterogeneity and plasticity. They often drive tumor-promoting functions that include angiogenesis, metastasis, immunosuppression, and therapy resistance, while also modulating cancer-cell cytotoxic elimination and phagocytosis. TAMs further coordinate innate and adaptive immunity through interactions with other immune cells. This review summarizes up-to-date TAM roles in tumor progression and highlights recent TAM-targeting therapeutic advances, along with key obstacles and future perspectives.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/targeting-tumor-associated-macrophages-review/327641/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/targeting-tumor-associated-macrophages-review/327641.png","ImageObject",300,407,{"name":42,"@type":43},"Aurora","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-11","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What role do tumor-associated macrophages play in tumor progression?","Question",{"text":63,"@type":64},"TAMs promote multiple tumor-driving processes such as angiogenesis, metastasis, immunosuppression, and resistance to therapy. They also regulate cytotoxic elimination and phagocytosis of cancer cells.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does TAM heterogeneity and plasticity affect their function?",{"text":68,"@type":64},"TAMs show phenotypic heterogeneity and plasticity that depend on environmental cues within the tumor microenvironment. This supports distinct, functionally relevant polarization states.",{"name":70,"@type":61,"acceptedAnswer":71},"What therapeutic strategies target TAMs and what challenges are discussed?",{"text":72,"@type":64},"The review summarizes recent TAM-targeting therapeutic strategies and discusses obstacles and perspectives for TAM-targeting cancer therapies, including the complexity of TAM roles in different contexts.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},327641,1790168179,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146,"preview_page_count":4},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","INTERNATIONAL JOURNAL OF ONCOLOGY 64: 60, 2024  \nTargeting tumor‑associated macrophages: Critical players in tumor progression and therapeutic strategies (Review)  \nPENGFEI SU 1,2 , OU LI 1,2 , KUN KE 1,2 , ZHICHEN JIANG 1,2 , JIANZHANG WU 1 , YUANYU WANG 1 , YIPING MOU 1,2 and WEIWEI JIN 1,2  \n1  \nDepartment of General Surgery, Cancer Center, Division of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital,  \n2  \nAffiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310000, P.R. China; Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310000, P.R. China  \nReceived March 1, 2024; Accepted April 19, 2024  \nDOI: 10.3892/ijo.2024.5648  \nAbstract. Tumor‑associated macrophages (TAMs) are essen‑ tial components of the tumor microenvironment (TME) and display phenotypic heterogeneity and plasticity associated  \nCorrespondence to: Professor Weiwei Jin, Department of General Surgery, Cancer Center, Division of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang 310000, P.R. China  \nE‑mail: [jinww@zju.edu.cn](jinww@zju.edu.cn)  \nAbbreviations: TAMs, tumor‑associated macrophages; TME, tumor microenvironment; TRMs, tissue resident macrophages; CSF1, colony‑stimulating factor 1; TGF‑β, transforming growth factor‑β; IL, interleukin; CCL, C‑C motif chemokine ligand; CXCL, C‑X‑C motif chemokine ligand; LPS, lipopolysaccharide; IFN‑γ, interferon‑γ; GM‑CSF, granulocyte‑macrophage colony‑stimulating factor; TLRs, Toll‑like receptors; MHC, major histocompatibility complex class; iNOS, inducible nitric oxide synthase; TNF‑α , tumor necrosis factor‑α; ROS, reactive oxygen species; RNS, reactive nitrogen species; Th, helper T cells; Treg, regulatory T cells; Arg, arginase; CD163, scavenger receptor; CD206, mannose receptor; VEGF, vascular endothelial growth factor; EMP, erythro‑myeloid progenitors; HSC, hematopoietic stem cell; EGF, epidermal growth factor; HIF‑1α , hypoxia‑inducible factor 1α; PDGF, platelet‑derived growth factor; MMP, matrix metalloproteinase; ECM, extracellular matrix; PDAC, pancreatic ductal adenocarcinoma; CRC, colorectal cancer; GC, gastric cancer; ICIs, immune checkpoint inhibitors; CTLA‑4, cytotoxic T lymphocyte antigen 4; PD‑1, programmed cell death protein 1; LILRB, leukocyte immunoglobulin‑like receptor B; EMT, epithelial‑mesenchymal transition; HCC, hepatocellular carcinoma; NK cells, natural killer cells; TSGCT, tenosynovial giant cell tumor; MDSCs, myeloid‑derived suppressor cells; CAR‑T, chimeric antigen receptor T cell; PTX, paclitaxel; DAMPs, damage‑associated molecular patterns; MARCO, macrophage receptor with collagenous structure; SIRPα , signal regulatory protein α; NA, not available; NSCLC, non‑small cell lung cancer  \nKey words: tumor‑associated macrophage, tumor microenvironment, tumor progression, targeted therapy  \nwith the stimulation of bioactive molecules within the TME. TAMs predominantly exhibit tumor‑promoting phenotypes involved in tumor progression, such as tumor angiogenesis, metastasis, immunosuppression and resistance to therapies. In addition, TAMs have the potential to regulate the cytotoxic elimination and phagocytosis of cancer cells and interact with other immune cells to engage in the innate and adap‑ tive immune systems. In this context, targeting TAMs has been a popular area of research in cancer therapy, and a comprehensive understanding of the complex role of TAMsin tumor progression and exploration of macrophage‑based therapeutic approaches are essential for future therapeutics against cancers. The present review provided a comprehen‑ sive and updated overview of the function of TAMs in tumor progression, summarized recent advances in TAM‑targeting therapeutic strategies and discussed the obstacles a","cbCailF9HkjKCRNQ","https://ap.wps.com/l/cbCailF9HkjKCRNQ","pdf",2718902,21,"English","# Contents\n## 1. Introduction\n## 2. Origin and heterogeneity of TAMs\n## 3. TAMs and tumor progression\n## 4. Therapeutic strategies targeting TAMs\n## 5. Combinations of TAMs-targeted and conventional therapies\n## 6. Conclusion and perspective","[{\"question\":\"What role do tumor-associated macrophages play in tumor progression?\",\"answer\":\"TAMs promote multiple tumor-driving processes such as angiogenesis, metastasis, immunosuppression, and resistance to therapy. They also regulate cytotoxic elimination and phagocytosis of cancer cells.\"},{\"question\":\"How does TAM heterogeneity and plasticity affect their function?\",\"answer\":\"TAMs show phenotypic heterogeneity and plasticity that depend on environmental cues within the tumor microenvironment. This supports distinct, functionally relevant polarization states.\"},{\"question\":\"What therapeutic strategies target TAMs and what challenges are discussed?\",\"answer\":\"The review summarizes recent TAM-targeting therapeutic strategies and discusses obstacles and perspectives for TAM-targeting cancer therapies, including the complexity of TAM roles in different contexts.\"}]","Targeting tumor-associated macrophages - Review | PDF",1789977709,53]