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Boron neutron capture therapy (BNCT) can improve the therapeutic ratio and reduce harm, but is limited by insufficient boron accumulation and short retention time. Recent developments focus on radiosensitizers designed to selectively accumulate in cancer-cell organelles to reduce side effects, overcome radioresistance, and enhance radiosensitivity. This review emphasizes nanomedicine-based organelle-targeted radiosensitizers, including nucleus, mitochondria, endoplasmic reticulum, and lysosomes, and presents organelle-targeted boron carriers for BNCT.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-the-organelle-for-radiosensitization-in-cancer-radiotherapy/339144/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-the-organelle-for-radiosensitization-in-cancer-radiotherapy/339144.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is conventional radiotherapy insufficient for effective cancer treatment?","Question",{"text":112,"@type":113},"Conventional radiotherapy is limited by low radiation energy deposition, damage to nearby normal tissues, and tumor resistance to radiation. These factors can prevent achieving the desired therapeutic effect.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What limitations does BNCT face in practice?",{"text":117,"@type":113},"BNCT improves the therapeutic ratio but remains constrained by insufficient boron accumulation in tumors and a short boron retention time, which limits curative outcomes.",{"name":119,"@type":110,"acceptedAnswer":120},"How do organelle-targeted radiosensitizers improve radiosensitization?",{"text":121,"@type":113},"They are designed to selectively accumulate in specific cancer-cell organelles. This strategy reduces side effects from normal tissue damage, helps overcome radioresistance, and improves overall radiosensitivity.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},339144,1790167833,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Asian Journal of Pharmaceutical Sciences 19 (2024) 100903  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \njournal [homepage:](homepage: www.elsevier.com/locate/AJPS)[ www.elsevier.com/locate/AJPS](homepage: www.elsevier.com/locate/AJPS)  \n| Review Article |  |  |  |\n| --- | --- | --- | --- |\n| Targeting the organelle for radiosensitization in cancer radiotherapy |  |  | |\n| Xiaoyan Sun a,f, Linjie Wu a,f, Lina Dub,∗, Wenhong Xuc,∗, Min Han a,c,d,e,f,∗\u003Cbr>a Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China\u003Cbr>b Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China\u003Cbr>c Department of Radiation Oncology, Key Laboratory of Cancer Prevention and Intervention, The Second Afliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China\u003Cbr>d Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou 310058, China\u003Cbr>eJinhua Institute of Zhejiang University, Jinhua 321299, China\u003Cbr>f National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China |  |  |  |\n| a r t i c l e i n f o |  | a b s t r a c t |  |\n| Article history:\u003Cbr>Received 6 October 2023 Revised 29 December 2023 Accepted 16 January 2024 Available online 10 March 2024 |  | Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation energy deposition, severe damage to surrounding normal cells, and high tumor resistance to radiation. Among various radiotherapy methods, boron neutron capture therapy (BNCT) has emerged as a principal approach to improve the therapeutic ratio of malignancies and reduce lethality to surrounding normal tissue, but it remains deficient in terms of insufficient boron accumulation as well as short retention time, which limits the curative effect. Recently, a series of radiosensitizers that can selectively accumulate in specific organelles of cancer cells have been developed to precisely target radiotherapy, thereby reducing side effects of normal tissue damage, overcoming radioresistance, and improving radiosensitivity. In this review, we mainly focus on the field of nanomedicine-based cancer radiotherapy and discuss the organelle-targeted radiosensitizers, specifically including nucleus, mitochondria, endoplasmic reticulum and lysosomes. Furthermore, the organelle-targeted boron carriers used in BNCT are particularly presented. Through demonstrating recent developments in organelle-targeted radiosensitization, we hope to provide insight into the design of organelle-targeted radiosensitizers for clinical cancer treatment.\u003Cbr>© 2024 Shenyang Pharmaceutical University. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license\u003Cbr>([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)) |  |\n| Keywords:\u003Cbr>Cancer radiotherapy Organelle-target Radiosensitization\u003Cbr>Boron neutron capture therapy Nanomedicines |  |  |  |\n\n∗ Corresponding authors.  \nE-mail [addresses:](addresses: dulina@188.com)[ dulina@188.com](addresses: dulina@188.com) (L. Du), [wenhongxu@zju.edu.cn](wenhongxu@zju.edu.cn) (W. Xu), [hanmin@zju.edu.cn](hanmin@zju.edu.cn) (M. Han).  \nPeer review under responsibility of Shenyang Pharmaceutical University.  \n[https://doi.org/10.1016/j.ajps.2024.100903](https://doi.org/10.1016/j.ajps.2024.100903)  \n1818-0876/© 2024 Shenyang Pharmaceutical University. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/))  \n1. Introduction  \nRadiotherapy (RT) is the most effective cytotoxic therapy for localized solid carcinomas and is widely used in current ","cbCaimtjfdmSL2MP","https://ap.wps.com/l/cbCaimtjfdmSL2MP","pdf",3396205,"English","# Introduction\n## Radiotherapy limitations\n## Boron neutron capture therapy (BNCT)\n## Organelle-targeted radiosensitizers","[{\"question\":\"Why is conventional radiotherapy insufficient for effective cancer treatment?\",\"answer\":\"Conventional radiotherapy is limited by low radiation energy deposition, damage to nearby normal tissues, and tumor resistance to radiation. These factors can prevent achieving the desired therapeutic effect.\"},{\"question\":\"What limitations does BNCT face in practice?\",\"answer\":\"BNCT improves the therapeutic ratio but remains constrained by insufficient boron accumulation in tumors and a short boron retention time, which limits curative outcomes.\"},{\"question\":\"How do organelle-targeted radiosensitizers improve radiosensitization?\",\"answer\":\"They are designed to selectively accumulate in specific cancer-cell organelles. This strategy reduces side effects from normal tissue damage, helps overcome radioresistance, and improves overall radiosensitivity.\"}]","Targeting the organelle for radiosensitization in cancer radiotherapy | PDF",1790028215]