[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330548-105":3,"doc-detail-330548-en":73,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":66,"head_meta":68,"extra_data":70,"updated_unix":72},105,"en","targeting-telomere-dynamics-as-an-effective-approach-for-the-development-of-cancer-therapeutics-review","Targeting Telomere Dynamics as an Effective Approach for the Development of Cancer Therapeutics - REVIEW","","Telomeres are protective structures at chromosome ends that maintain genome integrity, and their dynamics strongly influence cancer progression. This review frames targeting telomere dynamics as a therapeutic strategy and explains multiple molecular routes, including anti-telomerase immune activation, telomere shortening, induction of telomere dysfunction, and telomerase-responsive drug release systems. Preclinical and clinical agents interfere with telomere signaling and show potential as chemotherapy and immunotherapy, including possible effects on cancer stem cells and nanoparticle or antibody-drug conjugate delivery approaches.",{"@graph":14,"@context":65},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/targeting-telomere-dynamics-as-an-effective-approach-for-the-development-of-cancer-therapeutics-review/330548/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/targeting-telomere-dynamics-as-an-effective-approach-for-the-development-of-cancer-therapeutics-review/330548.png","ImageObject",300,407,{"name":42,"@type":43},"Aurora","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59],{"name":60,"@type":61,"acceptedAnswer":62},"How do telomere length patterns relate to different cancers?","Question",{"text":63,"@type":64},"A systematic analysis of tumor and normal samples found most cases with telomere shortening, while some cancers showed elongating telomeres. Differences across cancer types are summarized with examples such as testicular germ cell tumors and cervical cancer.","Answer","https://schema.org",{"og:url":32,"og:type":67,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":69,"canonical":32},"index,follow",{"doc_id":71,"site_id":7},330548,1790174840,{"code":4,"msg":74,"data":75},"success",{"doc_id":71,"user_id":76,"nickname":42,"user_avatar":77,"doc_module":4,"category_id":78,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":79,"file_id":80,"file_url":81,"file_type":82,"file_size":83,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":84,"language":85,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":86,"faqs":87,"seo_title":88,"seo_description":12,"update_tm":89,"read_time":90,"preview_page_count":4},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d",8,"International Journal of Nanomedicine Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nTargeting Telomere Dynamics as an Effective Approach for the Development of Cancer Therapeutics  \nHong-yu Tao, Chun-yan Zhao, Ying Wang , Wei-jin Sheng, Yong-su Zhen  \nLaboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China  \nCorrespondence: Wei-jin Sheng; Yong-su Zhen, Email [swj_zjnb@imb.cams.cn](swj_zjnb@imb.cams.cn); [zhenys@imb.pumc.edu.cn](zhenys@imb.pumc.edu.cn)  \n\n| Abstract: Telomere is a protective structure located at the end of chromosomes of eukaryotes, involved in maintaining the integrity and stability of the genome. Telomeres play an essential role in cancer progression; accordingly, targeting telomere dynamics emerges as an effective approach for the development of cancer therapeutics. Targeting telomere dynamics may work through multifaceted molecular mechanisms; those include the activation of anti-telomerase immune responses, shortening of telomere lengths, induction of telomere dysfunction and constitution of telomerase-responsive drug release systems. In this review, we summarize a wide variety of telomere dynamics-targeted agents in preclinical studies and clinical trials, and reveal their promising therapeutic potential in cancer therapy. As shown, telomere dynamics-active agents are effective as anti-cancer chemotherapeutics and immunotherapeutics. Notably, these agents may display efficacy against cancer stem cells, reducing cancer stem levels. Furthermore, these agents can be integrated with the capability of tumor-specific drug delivery by the constitution of related nanoparticles, antibody drug conjugates and HSAbased drugs.\u003Cbr>Keywords: telomere dynamics, telomerase, alternative lengthening of telomeres (ALT), cancer therapy |\n| --- |\n| Introduction\u003Cbr>Telomere is a protective structure located at the end of the linear chromosome of eukaryotes, which is made up of tandem repetitive DNA sequences and related proteins. It is essential for maintaining the integrity and stability of the genome. A cancer cell, originated from the aggregates of abnormal mutated cells, is characterized by uncontrollably infinite proliferation, infiltrating into surrounding tissues, further metastasizing to distant organs and ultimately leading to the death of host organisms.1 Remarkable advances in the field of telomere biology have revealed the paramount importance of telomere in cancer progression. However, slightly different from the general hypothesis, several analyses focused on the correlation of telomere lengths and cancer incidence reported that both longer and shorter telomeres were correlated with cancer development.2 A systematic analysis of telomere lengths of 18,430 samples covering tumor and normal tissues from 31 types of cancers revealed that 70% of samples displayed shortening telomere lengths in comparison with matched normal tissues and 30% showed elongating telomere lengths. In detail, elongated telomeres existed in testicular germ cell tumors, low grade glioma and sarcoma, whereas cervical cancer, endometrial cancer, uveal melanoma, lymphoma, kidney papillary and kidney chromophobe carcinoma showed shortened telomeres.3 With the participation of telomerase and alternative lengthening of telomeres (ALT) pathway, longer telomeres indicate more replicative times and provide favorable opportunity for the unlimited proliferation of cancer cells. Meanwhile, shortened telomeres may cause the telomere crisis and genomic instability, which also facilitate tumor progression.4,5 Thus, instead of merely affecting telomere lengths, seeking versatile mechanisms which refer to targeting telomere dynamics may achieve satisfactory results in cancer therapy. The emerging multifaceted strategy as chemotherapeutic, immunotherapeutic and |\n\nReceived: 7 November 2023  \nAccept","cbCaiiMgZ9su4omU","https://ap.wps.com/l/cbCaiiMgZ9su4omU","pdf",3437319,21,"English","# Introduction\n## Telomere structure and role in genome stability\n## Telomere length, telomerase, and cancer progression\n## Targeting telomere dynamics for therapeutic benefit\n# Telomere Dynamics as Drug Target\n## Historical discovery of telomeres\n## Telomere sequence conservation","[{\"question\":\"How do telomere length patterns relate to different cancers?\",\"answer\":\"A systematic analysis of tumor and normal samples found most cases with telomere shortening, while some cancers showed elongating telomeres. Differences across cancer types are summarized with examples such as testicular germ cell tumors and cervical cancer.\"}]","Targeting Telomere Dynamics as an Effective Approach for the Development of Cancer Therapeutics - REVIEW | PDF",1789989373,53,{"code":4,"msg":74,"data":92},[93,97,101,105,110,115,120,123,128,131,134],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},7,"Healthcare",40,"healthcare",{"id":78,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":121,"slug":122},30,"research-report",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":55,"slug":133},"Lifestyle","lifestyle",{"id":135,"doc_module":4,"doc_module_name":25,"category_name":136,"show_sort_weight":106,"slug":137},19,"General","general"]