[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331056-105":59,"doc-detail-331056-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","targeting-notch-signaling-pathways-with-natural-bioactive-compounds-a-promising-approach-against-cancer-a-review","Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer - a review","","Notch signaling is abnormally activated in solid and hematological tumors, driving cell differentiation, survival, proliferation, and angiogenesis. Cross-talk between Notch and other oncogenic pathways increases malignancy aggressiveness. This review summarizes natural bioactive compounds that inhibit human cancers by suppressing the Notch pathway and blocking Notch crosstalk, aiming to support further development of rational therapeutic regimens and novel anticancer drugs. Notch is presented as challenging yet promising for oncology.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-notch-signaling-pathways-with-natural-bioactive-compounds-a-promising-approach-against-cancer-a-review/331056/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-notch-signaling-pathways-with-natural-bioactive-compounds-a-promising-approach-against-cancer-a-review/331056.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is Notch signaling considered an important target in cancer?","Question",{"text":112,"@type":113},"Notch signaling is abnormally activated in many malignancies and regulates proliferation, differentiation, survival, and angiogenesis, contributing to cancer aggressiveness.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do natural bioactive compounds relate to the Notch pathway?",{"text":117,"@type":113},"Natural bioactive compounds can alter signaling molecules linked to or interacting with Notch pathways, including inhibiting Notch signaling and reducing Notch cross-talk with other oncogenic pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the main goal of targeting Notch in anticancer therapy?",{"text":121,"@type":113},"By modulating Notch signaling, the approach seeks to weaken tumor aggressiveness and improve outcomes, supporting the development of rational therapeutic regimens and novel anticancer drugs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331056,1790195662,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TYPE Review  \nPUBLISHED 18 July 2024  \nDOI 10.3389/fphar.2024.1412669  \nOPEN ACCESS  \nEDITED BY  \nAntonella D’Anneo,  \nUniversity of Palermo, Italy  \nREVIEWED BY  \nMagesh Muthu,  \nWayne State University, United States Armel Hervé Nwabo Kamdje, University of Garoua, Cameroon Maria Pia Felli,  \nSapienza University of Rome, Italy  \n*CORRESPONDENCE  \nYing Xie,  \n [leoxieying16@outlook.com](leoxieying16@outlook.com)[ ](leoxieying16@outlook.com)Peiyu Yan,  \n [pyyan@must.edu. mo](pyyan@must.edu. mo)[ ](pyyan@must.edu. mo)Rong Rong,  \n [rosierong@163.com](rosierong@163.com)  \nRECEIVED 05 April 2024  \nACCEPTED 27 June 2024  \nPUBLISHED 18 July 2024  \nCITATION  \nYang J, Sun Q, Liu X, Yang Y, Rong R, Yan P and Xie Y (2024), Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer.  \nFront. Pharmacol. 15:1412669 .  \ndoi: 10.3389/fphar.2024.1412669  \nCOPYRIGHT  \n© 2024 Yang, Sun, Liu, Yang, Rong, Yan and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nTargeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer  \nJia Yang 1,2,3, Qihui Sun 1,4, Xiaoyun Liu 5, Yong Yang 5, Rong Rong 1,2*, Peiyu Yan 2* and Ying Xie 3*  \n1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, 2State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China, 3State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, 4School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China, 5Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China  \nNotch signaling pathway is activated abnormally in solid and hematological tumors, which perform essential functions in cell differentiation, survival, proliferation, and angiogenesis. The activation of Notch signaling and communication among Notch and other oncogenic pathways heighten malignancy aggressiveness. Thus, targeting Notch signaling offers opportunities for improved survival and reduced disease incidence. Already, most attention has been given to its role in the cancer cells. Recent research shows that natural bioactive compounds can change signaling molecules that are linked to or interact with the Notch pathways. This suggests that there may be a link between Notch activation and the growth of tumors. Here, we sum up the natural bioactive compounds that possess inhibitory effects on human cancers by impeding the Notch pathway and preventing Notch crosstalk with otheroncogenic pathways, which provoke further study of these natural products to derive rational therapeutic regimens for the treatment of cancer and develop novel anticancer drugs. This review revealed Notch as a highly challenging but promising target in oncology.  \nKEYWORDS  \nnotch signaling, crosstalk, oncogenic pathways, phytochemicals, cancer  \nAbbreviations: Notch1/2/3/4, Notch receptor 1/2/3/4; DLL1/3/4, Delta-like protein 1/3/4; ADAM, Adisintegrin and metalloprotease; NECD, extracellular domain; NICD, intracellular domain of Notch; CSL, CBF1, Suppressor of Hairless, Lag-1; EGCG, Epigallocatechin-3-gallate; GSIs, gamma-secretase inhibitors; RBPJ, recombination signal-binding protein of immunoglobulin kappa J region; PTCH, patched receptor; SMO, smoothened; SUFU, suppressor of fused; COS2, costal 2; PKA, protein ki","cbCaiu8tnL0Z6zP2","https://ap.wps.com/l/cbCaiu8tnL0Z6zP2","pdf",2417616,17,"English","# 1 Introduction\n## Notch signaling in cancer\n## Current cancer treatment challenges and need for new targets","[{\"question\":\"Why is Notch signaling considered an important target in cancer?\",\"answer\":\"Notch signaling is abnormally activated in many malignancies and regulates proliferation, differentiation, survival, and angiogenesis, contributing to cancer aggressiveness.\"},{\"question\":\"How do natural bioactive compounds relate to the Notch pathway?\",\"answer\":\"Natural bioactive compounds can alter signaling molecules linked to or interacting with Notch pathways, including inhibiting Notch signaling and reducing Notch cross-talk with other oncogenic pathways.\"},{\"question\":\"What is the main goal of targeting Notch in anticancer therapy?\",\"answer\":\"By modulating Notch signaling, the approach seeks to weaken tumor aggressiveness and improve outcomes, supporting the development of rational therapeutic regimens and novel anticancer drugs.\"}]","Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer - a review | PDF",1789991382,43]