[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427863-105":59,"doc-detail-427863-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","targeting-mgll-terazosin-regulates-triglyceride-metabolism-to-mitigate-endothelial-cell-senescence","TARGETING MGLL - TERAZOSIN REGULATES TRIGLYCERIDE METABOLISM TO MITIGATE ENDOTHELIAL CELL SENESCENCE","","Metabolic disorders frequently originate in senescent endothelial cells, damaging endothelial function, lowering vasodilation, and increasing vascular stiffness, thereby promoting cardiovascular disease. Molecular mechanisms linking endothelial senescence to vascular aging remain insufficiently defined, limiting therapeutic development. This study evaluates terazosin in aged mice and human umbilical vein endothelial cells using SA-β-gal staining, lipidomics, and molecular docking. Terazosin improves vasodilation, reduces stiffness, and suppresses senescence markers, while modulating glycerolipid metabolism by decreasing palmitic acid accumulation via MGLL.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-mgll-terazosin-regulates-triglyceride-metabolism-to-mitigate-endothelial-cell-senescence/427863/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-mgll-terazosin-regulates-triglyceride-metabolism-to-mitigate-endothelial-cell-senescence/427863.png","ImageObject",300,407,{"name":92,"@type":93},"Taylor Morgan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-17","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are senescent endothelial cells important for cardiovascular disease development?","Question",{"text":113,"@type":114},"Senescent endothelial cells impair endothelial function, reduce vasodilation, and increase vascular stiffness, all of which contribute to cardiovascular disease.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What experimental approaches were used to study terazosin’s effects?",{"text":118,"@type":114},"The study used in vivo aged mice and in vitro HUVEC models, applying SA-β-gal staining, lipidomics analysis, and molecular docking simulations.",{"name":120,"@type":111,"acceptedAnswer":121},"How does terazosin mitigate endothelial cell senescence according to the findings?",{"text":122,"@type":114},"Terazosin reduces senescence markers and improves vascular function, partly by modulating glycerolipid metabolism and lowering palmitic acid accumulation through targeting MGLL.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},427863,1790722633,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":81},1099523885336,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Innovation in Aging, 2025, Vol. 9, No. S2 855  \nAbstract citation ID: igaf122.2894  \nTARGETING MGLL: TERAZOSIN REGULATES  \nTRIGLYCERIDE METABOLISM TO MITIGATE  \nENDOTHELIAL CELL SENESCENCE  \nJie Huang1, Jinghua Yan2, Hao Nie2, and Cuntai Zhang3,  \n1. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei, China (People’s Republic), 2. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (People’s Republic), 3. Huazhong University of Science and Technology, Wuhan, Hubei, China (People’s Republic)  \nMetabolic disorders often arise in senescent endothelial cells, impairing endothelial function, leading to diminished vasodilation and increased vascular stiffness, contributing to the development of cardiovascular disease (CVD). Despite notable advancements, the molecular mechanisms driving endothelial cell senescence and its contribution to vascular aging remain poorly understood. This knowledge gap hinders the development of effective therapeutic strategies. This study investigates the role of terazosin (TZ) in mitigating vascular endothelial cell senescence, with emphasis on its impact on glycerolipid metabolism. Using both in vivo (aged mice) and in vitro (human umbilical vein endothelial cells, HUVECs) models, the research employs techniques such assenescence-associated β-galactosidase (SA-β-gal) staining, lipidomics analysis, and molecular docking simulations to uncover the underlying mechanisms. The results demonstrated that TZ treatment could significantly improve endothelial-dependent vasodilation, reduce vascular stiffness, and attenuate senescence markers in aged mice. Lipidomics analysis revealed that TZ could modulate glycerolipid metabolism, specifically by reducing palmitic acid accumulation in senescent endothelial cells. Further investigation identified monoglyceride lipase (MGLL), which hydrolyzed monoglycerides into palmitic acid and glycerol, as a key player in endothelial cell senescence. TZ reduced palmitic acid accumulation by targeting MGLL, thereby mitigating endothelial senescence. In conclusion, this study provides novel insights into the anti-senescence effects of TZ, highlighting its potential as a therapeutic agent for age-related vascular diseases. Moreover, the identification of MGLL as a critical regulator of glycerolipid metabolism and endothelial cell senescence offers a promising target for future interventions in vascular aging.","cbCaifdKYGz7cD4t","https://ap.wps.com/l/cbCaifdKYGz7cD4t","pdf",771627,"English","# Abstract\n## Background\n## Methods\n## Key Findings\n## Conclusion and Implications","[{\"question\":\"Why are senescent endothelial cells important for cardiovascular disease development?\",\"answer\":\"Senescent endothelial cells impair endothelial function, reduce vasodilation, and increase vascular stiffness, all of which contribute to cardiovascular disease.\"},{\"question\":\"What experimental approaches were used to study terazosin’s effects?\",\"answer\":\"The study used in vivo aged mice and in vitro HUVEC models, applying SA-β-gal staining, lipidomics analysis, and molecular docking simulations.\"},{\"question\":\"How does terazosin mitigate endothelial cell senescence according to the findings?\",\"answer\":\"Terazosin reduces senescence markers and improves vascular function, partly by modulating glycerolipid metabolism and lowering palmitic acid accumulation through targeting MGLL.\"}]","TARGETING MGLL - TERAZOSIN REGULATES TRIGLYCERIDE METABOLISM TO MITIGATE ENDOTHELIAL CELL SENESCENCE | PDF",1790644999]