[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-329714-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-329714-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","targeting-matrix-metalloproteinases-and-their-inhibitors-in-melanoma","Targeting Matrix Metalloproteinases and Their Inhibitors in Melanoma","","Malignant melanoma represents a highly lethal dermatological cancer, with mortality largely driven by metastatic spread. Early diagnosis and treatment can improve outcomes because therapeutic success correlates with the depth of tumor invasion. Matrix metalloproteinases (MMPs) are central to melanoma initiation and progression, with several key MMPs (e.g., MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14) strongly implicated in disease development. The tumor microenvironment and extracellular matrix (ECM) are critical regulators of progression. This review summarizes how MMPs and their inhibitors contribute to ECM degradation and melanoma progression, and evaluates their potential as therapeutic targets.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/targeting-matrix-metalloproteinases-and-their-inhibitors-in-melanoma/329714/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/targeting-matrix-metalloproteinases-and-their-inhibitors-in-melanoma/329714.png","ImageObject",300,407,{"name":42,"@type":43},"Theodora","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is early detection of melanoma important for treatment outcomes?","Question",{"text":63,"@type":64},"Early detection is crucial because the effectiveness of treatment is directly related to the depth of the cancerous growth.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What role do matrix metalloproteinases (MMPs) play in melanoma?",{"text":68,"@type":64},"MMPs regulate initiation and progression of melanoma, largely through their involvement in extracellular matrix degradation and remodeling.",{"name":70,"@type":61,"acceptedAnswer":71},"How are melanoma deaths most commonly associated with disease progression?",{"text":72,"@type":64},"The document states that mortality is primarily due to the occurrence of metastases, making metastatic disease the most frequent cause of death.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},329714,1790828533,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","Review  \nTargeting Matrix Metalloproteinases and Their Inhibitors in Melanoma  \nOrest Szczygielski 1,*, Emilia Da˛browska 2, Sylwia Niemyjska 2, Andrzej Przylipiak 3,4 and Monika Zajkowska 5  \nCitation: Szczygielski, O.; Da˛browska, E.; Niemyjska, S.; Przylipiak, A.; Zajkowska, M. Targeting Matrix Metalloproteinases and Their Inhibitors in Melanoma. Int. J. Mol. Sci. 2024, 25, 13558. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms252413558](10.3390/ijms252413558)  \nAcademic Editor: Karel Smetana, Jr.  \nReceived: 18 November 2024  \nRevised: 10 December 2024  \nAccepted: 16 December 2024  \nPublished: 18 December 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Clinic of Paediatric Surgery, Institute of Mother and Child, Kasprzaka Str 17a, 01-211 Warsaw, Poland  \n2 General Hospital in Wysokie Mazowieckie, Szpitalna Str 5, 18-200 Wysokie Mazowieckie, Poland  \n3 Department of Esthetic Medicine, Medical University of Bialystok, 15-267 Bialystok, Poland  \n4 Department of Health Sciences, University of Lomza, 18-400 Lomza, Poland  \n5 Faculty of Medicine with the Division of Dentistry and Division of Medical Education in English, Medical University of Bialystok, 15-269 Bialystok, Poland; [monika.zajkowska@umb.edu.pl](monika.zajkowska@umb.edu.pl)  \n* Correspondence: [orest1966@o2.pl](orest1966@o2.pl)  \nAbstract: Malignant melanoma is one of the most important dermatological neoplasms. The high mortality rate associated with this skin disease is primarily due to the occurrence of metastases, while the diagnosis and treatment of melanoma in its early stages has a favorable prognosis. Early detection is crucial because the success of treatment is directly related to the depth of cancerous growth. The family of matrix metalloproteinases (MMPs) plays a critical role in the initiation and progression of melanoma. Prominent MMPs, including MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, and MMP-14, have been shown to significantly contribute to the development of melanoma. The tumor microenvironment, particularly the extracellular matrix (ECM), has emerged as a critical factor in modulating cancer progression. This review focuses on the role of matrix metalloproteinases and their inhibitors in ECM degradation and the subsequent progression of melanoma, as well as their potential as therapeutic targets.  \nKeywords: dermatological; skin disease; drugs; MMPs  \n1. Introduction  \nMelanoma is one of the less common neoplasms, accounting for fewer than five percent of all skin cancers. However, it is the most lethal, responsible for approximately 80% of skin tumor-related deaths worldwide [1] . Melanoma is a malignant neoplasm that originates from melanocytes, which are derived from neural crest cells and are responsible for the production of the pigment melanin. Melanocytes are predominantly located in the epidermis, hair follicles, along the surfaces of mucous membranes, within the meninges, and in the choroid layer of the eye [2–4] . Given the distribution of these cells, melanoma can arise in various anatomical sites, leading to classifications such as mucous membrane melanoma, ocular melanoma, and cutaneous melanoma. The most prevalent form is cutaneous melanoma, which accounts for over 90% of all melanoma cases, and its incidence is continually on the rise [5] . Cutaneous melanoma is the leading cause of mortality due to skin neoplasm, primarily attributable to its capacity for metastasis [6] . Consequently, the presence of metastatic disease is the most frequent cause of mortality associated with melanoma, and the estimated 5-year overall survival rate for patients with stage IV melanoma is approximately 23%[7] . Althou","cbCaitaM2e9SV76i","https://ap.wps.com/l/cbCaitaM2e9SV76i","pdf",961492,18,"English","# 1. Introduction\n## Matrix metalloproteinases (MMPs) and their role in melanoma\n# Abstract\n# Keywords","[{\"question\":\"Why is early detection of melanoma important for treatment outcomes?\",\"answer\":\"Early detection is crucial because the effectiveness of treatment is directly related to the depth of the cancerous growth.\"},{\"question\":\"What role do matrix metalloproteinases (MMPs) play in melanoma?\",\"answer\":\"MMPs regulate initiation and progression of melanoma, largely through their involvement in extracellular matrix degradation and remodeling.\"},{\"question\":\"How are melanoma deaths most commonly associated with disease progression?\",\"answer\":\"The document states that mortality is primarily due to the occurrence of metastases, making metastatic disease the most frequent cause of death.\"}]","Targeting Matrix Metalloproteinases and Their Inhibitors in Melanoma | PDF",1789985296,45]