[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331462-105":59,"doc-detail-331462-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","targeting-lipid-metabolism-in-cancer-stem-cells-for-anticancer-treatment-review","Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment - Review","","Cancer stem cells (CSCs), also called tumor-initiating cells (TICs), exist as rare subpopulations that drive relapse and therapeutic resistance. Lipid metabolic reprogramming shapes drug efficacy by affecting diffusion, membrane permeability, mitochondrial function, and lipid composition, thereby promoting chemoresistance across cancers. Autophagy is tightly connected to lipid regulation, yet the mechanisms by which autophagy and lipid metabolism coordinate CSC control remain insufficiently defined. This review summarizes recent advances on lipid metabolism in CSCs, highlighting key regulatory enzymes, inhibitors, and autophagy’s role in lipid homeostasis, aiming to guide new anticancer target discovery.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-lipid-metabolism-in-cancer-stem-cells-for-anticancer-treatment-review/331462/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-lipid-metabolism-in-cancer-stem-cells-for-anticancer-treatment-review/331462.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are cancer stem cells (CSCs) important for cancer relapse and therapy resistance?","Question",{"text":112,"@type":113},"CSCs are small subpopulations that are crucial for relapse and resistance. 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Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment. Int. J. Mol. Sci. 2024, 25, 11185. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms252011185  \nAcademic Editor: Sabrina Battista  \nReceived: 6 September 2024  \nRevised: 14 October 2024  \nAccepted: 16 October 2024  \nPublished: 17 October 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea; [manishbiochem@gmail.com](manishbiochem@gmail.com) (M.K.S.); [sunheehan@khu.ac.kr](sunheehan@khu.ac.kr) (S.H.)  \n2 Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea  \n3 Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea  \n* Correspondence: [sgskim@khu.ac.kr](sgskim@khu.ac.kr) (S.K.); [iskang@khu.ac.kr](iskang@khu.ac.kr) (I.K.); Tel.: +82-2-961-0524 (S.K.);+82-2-961-0922 (I.K.)  \nAbstract: Cancer stem cells (CSCs), or tumor-initiating cells (TICs), are small subpopulations (0.0001–0.1%) of cancer cells that are crucial for cancer relapse and therapy resistance. The elimination of each CSC is essential for achieving long-term remission. Metabolic reprogramming, particularly lipids, has a significant impact on drug efficacy by influencing drug diffusion, altering membrane permeability, modifying mitochondrial function, and adjusting the lipid composition within CSCs. These changes contribute to the development of chemoresistance in various cancers. The intricate relationship between lipid metabolism and drug resistance in CSCs is an emerging area of research, as different lipid species play essential roles in multiple stages of autophagy. However, the link between autophagy and lipid metabolism in the context of CSC regulation remains unclear. Understanding the interplay between autophagy and lipid reprogramming in CSCs could lead to the development of new approaches for enhancing therapies and reducing tumorigenicity in these cells. In this review, we explore the latest findings on lipid metabolism in CSCs, including the role of key regulatory enzymes, inhibitors, and the contribution of autophagy in maintaining lipid homeostasis. These recent findings may provide critical insights for identifying novel pharmacological targets for effective anticancer treatment.  \nKeywords: autophagy; cancer stem cell; drug resistance; lipids; stemness; tumor microenvironment  \n1. Introduction  \nCancer is a multifactorial disease and ranked as the second cause of death in the United States in 2020 and 2021 [1] . The National Cancer Institute GDC Data Portal reports an increasing number of cases every year, with the highest cases being bone marrow and blood cancer, followed by lung cancer. While advanced-stage cancer offers bleak prospects for complete recovery and reduces survival rates, early detection, accurate diagnosis, and effective treatment are crucial for improving a patient’s quality of life and increasing survival rates. Despites advancements in treatment, recurrence and relapse rates remain high, largely due to tumor heterogeneity and therapy resistance. CSCs have been identified as significant contributors to drug resistance and tumor recurrence.  \nCSCs use alternative sources of energy and altered metabolism to thrive in the tumor microenvironment [2] . They utilize substrates, such as glutamine, serine, ","cbCaiabDyi8vvZqY","https://ap.wps.com/l/cbCaiabDyi8vvZqY","pdf",2956567,28,"English","# Introduction\n# Cancer Stem Cells (CSCs)","[{\"question\":\"Why are cancer stem cells (CSCs) important for cancer relapse and therapy resistance?\",\"answer\":\"CSCs are small subpopulations that are crucial for relapse and resistance. Eliminating each CSC is considered essential for achieving long-term remission.\"},{\"question\":\"How does lipid metabolism influence drug resistance in CSCs?\",\"answer\":\"Lipid metabolic changes affect drug efficacy by influencing drug diffusion, membrane permeability, mitochondrial function, and the lipid composition inside CSCs, which contributes to chemoresistance.\"},{\"question\":\"What is the relationship between autophagy and lipid metabolism in CSCs according to the review?\",\"answer\":\"Autophagy is a key pathway for protein degradation and nutrient recycling, and induced autophagy has been reported in CSCs. The review highlights that the detailed link between autophagy and lipid metabolism in CSC regulation is not fully clear, and clarifying it could support new therapeutic approaches.\"}]","Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment - Review | PDF",1789993344,71]