[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-367584-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-367584-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","targeting-gastrointestinal-cancers-with-carvacrol-mechanistic-insights-and-therapeutic-potential","Targeting Gastrointestinal Cancers with Carvacrol - Mechanistic Insights and Therapeutic Potential","","Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, create a major global health burden through high incidence, aggressiveness, and constrained treatment outcomes. This review evaluates carvacrol, a naturally occurring monoterpenoid phenol from oregano and other aromatic plants, and its ability to modulate apoptosis, inflammation, angiogenesis, and metastasis-related molecular pathways. Preclinical evidence highlights selective anticancer activity with reduced harm to healthy tissue, while nanotechnology and combination regimens may improve pharmacological performance; clinical validation is still required.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/targeting-gastrointestinal-cancers-with-carvacrol-mechanistic-insights-and-therapeutic-potential/367584/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/targeting-gastrointestinal-cancers-with-carvacrol-mechanistic-insights-and-therapeutic-potential/367584.png","ImageObject",300,407,{"name":42,"@type":43},"Putri","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are gastrointestinal (GI) cancers considered a major global health challenge?","Question",{"text":63,"@type":64},"GI cancers are linked to high incidence and aggressive progression, and they account for a substantial share of new cases and cancer-related deaths worldwide.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What biological mechanisms does carvacrol target in GI cancers?",{"text":68,"@type":64},"Carvacrol is described as modulating multiple pathways related to apoptosis, inflammation, angiogenesis, and metastasis.",{"name":70,"@type":61,"acceptedAnswer":71},"How might nanotechnology improve carvacrol’s therapeutic potential?",{"text":72,"@type":64},"Nanotechnology is reported to enhance solubility and stability and support tumor-targeted delivery, improving the drug’s pharmacological profile.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},367584,1790289102,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Review  \nTargeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential  \nNitika Patwa 1,†, Gagandeep Singh 2, Vikas Sharma 3, Priyanka Chaudhary 4, Bunty Sharma 5, Shafiul Haque 6,7, Vikas Yadav 8, Shakti Ranjan Satapathy 8, *,‡ and Hardeep Singh Tuli 9, *,‡  \nAcademic Editor: Javier Martínez Useros  \nReceived: 13 April 2025  \nRevised: 17 May 2025  \nAccepted: 20 May 2025  \nPublished: 27 May 2025  \nCitation: Patwa, N.; Singh, G.; Sharma, V.; Chaudhary, P.; Sharma, B.; Haque, S.; Yadav, V.; Satapathy, S.R.; Tuli, H.S. Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential. Biomolecules 2025, 15, 777. [https://](https://)[ ](https://)[doi.org/10.3390/biom15060777](doi.org/10.3390/biom15060777)  \n[Copyright:](Copyright:) © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Biotechnology, DAV College, Ambala 133001, Haryana, India; [nitika0491@gmail.com](nitika0491@gmail.com)  \n2 Section of Microbiology , Central Ayurveda Research Institute, Jhansi 284003, Uttar Pradesh, India; [gsk.ccras@gmail.com](gsk.ccras@gmail.com)  \n3 Department of Biotechnology, Ambala College of Engineering and Applied Research, Ambala 133001, Haryana, India; [vikas.bt@ambalacollege.ac.in](vikas.bt@ambalacollege.ac.in)  \n4 Department of Zoology, DAV College (Lahore), Ambala 133001, Haryana, India; [priyankadavambala@gmail.com](priyankadavambala@gmail.com)  \n5 Department of Biotechnology, Graphic Era (Deemed to Be University), Dehradun 248001, Uttarakhand, India; [sharmabunty097@gmail.com](sharmabunty097@gmail.com)  \n6 Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan 45142, Saudi Arabia; [shafiul.haque@hotmail.com](shafiul.haque@hotmail.com)  \n7 School of Medicine, Universidad Espiritu Santo, Samborondon 091650, Ecuador  \n8 Cell & Experimental Pathology, Department of Translational Medicine, Lund University,  \n200 41 Malmo, Sweden; [vikas.yadav@med.lu.se](vikas.yadav@med.lu.se)  \n9 Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala 133001, Haryana, India  \n* Correspondence: [shakti_ranjan.satapathy@med.lu.se](shakti_ranjan.satapathy@med.lu.se) (S.R.S.); [hardeep.biotech@gmail.com](hardeep.biotech@gmail.com) (H.S.T.)  \n† Current address: University Centre for Research & Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali 140413, Punjab, India.  \n‡ These authors contributed equally to this work.  \nAbstract: Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, represent a major global health burden due to their high incidence, aggressive nature, and limited treatment outcomes. This review explores the therapeutic potential of carvacrol, a naturally occurring monoterpenoid phenol predominantly found in oregano and other aromatic plants. Carvacrol has demonstrated strong anticancer properties by modulating multiple molecular pathways governing apoptosis, inflammation, angiogenesis, and metastasis. Preclinical studies have revealed its ability to selectively target cancer cells while sparing healthy tissue. Advances in nanotechnology have further enhanced its pharmacological profile by improving solubility, stability, and tumor-targeted delivery. Additionally, carvacrol shows synergistic effects when used in combination with conventional chemotherapeutics. While the evidence is promising, clinical studies are needed to validate its translational potential. This review aims to consolidate current findings and encourage further investigation into carvacrol’s a","cbCaimYoUWP7VKdl","https://ap.wps.com/l/cbCaimYoUWP7VKdl","pdf",618315,14,"English","# Introduction\n## GI cancer burden and risk factors\n## Limitations of current chemotherapy and need for alternatives\n# Therapeutic potential of carvacrol","[{\"question\":\"Why are gastrointestinal (GI) cancers considered a major global health challenge?\",\"answer\":\"GI cancers are linked to high incidence and aggressive progression, and they account for a substantial share of new cases and cancer-related deaths worldwide.\"},{\"question\":\"What biological mechanisms does carvacrol target in GI cancers?\",\"answer\":\"Carvacrol is described as modulating multiple pathways related to apoptosis, inflammation, angiogenesis, and metastasis.\"},{\"question\":\"How might nanotechnology improve carvacrol’s therapeutic potential?\",\"answer\":\"Nanotechnology is reported to enhance solubility and stability and support tumor-targeted delivery, improving the drug’s pharmacological profile.\"}]","Targeting Gastrointestinal Cancers with Carvacrol - Mechanistic Insights and Therapeutic Potential | PDF",1790171502,35]