[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-381857-105":59,"doc-detail-381857-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","targeting-ferroptosis-in-melanoma-cancer-therapeutics","Targeting ferroptosis in melanoma - cancer therapeutics","","Melanoma is a highly aggressive skin cancer whose incidence has risen rapidly, accounting for a small fraction of cases yet causing most skin cancer deaths. New therapies are needed to improve overall survival, especially given resistance to existing treatment modalities. Ferroptosis is a distinct regulated cell death process marked by iron and lipid peroxide accumulation, playing a key role in tumor progression. Inducing ferroptosis can suppress melanoma growth and tumorigenesis. The review summarizes ferroptosis characteristics and discusses its potential applications in melanoma cancer treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-ferroptosis-in-melanoma-cancer-therapeutics/381857/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-ferroptosis-in-melanoma-cancer-therapeutics/381857.png","ImageObject",300,407,{"name":92,"@type":93},"Kurz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is melanoma considered a major health problem despite its relatively low incidence?","Question",{"text":112,"@type":113},"Melanoma makes up only about 1% of skin cancers but leads to a high majority of skin cancer deaths due to its aggressive nature and high-risk progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What defines ferroptosis and how does it differ from other forms of cell death?",{"text":117,"@type":113},"Ferroptosis is a regulated cell death process distinguished from autophagy, apoptosis, necrosis, and pyroptosis by biochemistry, genetics, and morphology. It occurs mainly through the accumulation of iron and lipid peroxides in cells.",{"name":119,"@type":110,"acceptedAnswer":120},"How can targeting ferroptosis help melanoma therapy?",{"text":121,"@type":113},"Studies described in the review indicate that ferroptosis plays a key role in tumor progression. Inducing ferroptosis in melanoma cells can inhibit tumor cell growth and reduce back warding tumorigenesis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381857,1790521723,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Khorsandi et al.  \nCell Communication and Signaling (2023) 21:337 [https://doi.org/10.1186/s12964-023-01296-w](https://doi.org/10.1186/s12964-023-01296-w)  \nCell Communication and Signaling  \n REVIEW Open Access  \nTargeting ferroptosis in melanoma: cancer therapeutics  \nKhatereh Khorsandi 1*, HomaSadat Esfahani1, Saeedeh Keyvani‑ Ghamsari2 and Parisa lakhshehei3  \nAbstract  \nMelanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for only about 1% of skin cancers but leads to a high majority of skin cancer deaths. Thus, new useful therapeutic approaches are currently required, to state effective treatments to consistently enhance the overall survival rate of melanoma patients. Ferroptosis is a recently identified cell death process, which is different from autophagy, apoptosis, necrosis, and pyroptosis in terms of biochemistry, genetics, and morphology which plays an important role in cancer treatment. Ferroptosis happens mostly by accumulating iron and lipid peroxides in the cell. Recently, studies have revealed that ferroptosis has a key role in the tumor’s progression. Especially, inducing ferroptosis in cells can inhibit the tumor cells’ growth, leading to back warding tumorigenesis. Here, we outline the ferroptosis characteristics from its basic role in melanoma cancer and mention its possible applications in melanoma cancer treatment. Keywords Ferroptosis, Melanoma, Cell death, Cancer treatment, Targeted therapy  \nIntroduction  \nMelanoma is the most invasive skin cancer, and metastatic melanoma has the highest risk of death with a median survival rate of nearly 6 months [1]. Melanoma prevalence is significantly rising all around the world [2, 3]. Specialized pigment cells are known as melanocytes, which are found in the basal epidermis, and lead to melanoma [4]. In a normal physiological condition, keratinocytes control melanocyte growth and activity [4]. Due to abnormalities in critical genes that control cell growth, melanocytes cannot adequately respond to regulatory cues from keratinocytes, which ultimately results in aberrant growth. Melanoma can develop without a precursor  \n*Correspondence: Khatereh Khorsandi  \n[khorsandi.kh@ut.ac.ir](khorsandi.kh@ut.ac.ir); [Biochem.kh@gmail.com](Biochem.kh@gmail.com)  \n1 Department of Photodynamics, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran  \n2 Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran  \n3 Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran  \nlesion, although in certain instances, the development of a nevus or mole marks the beginning of this aberrant growth [5]. Melanoma has also been identified from transformed stem cells. Stem cell markers such as CD20, and CD133, as well as OCT 4, NANOG, and pSTAT 3, have been recognized in melanoma [6, 7]. A challenge in treating melanoma is the variety of cell populations with stem cell characteristics since some of these cells are resistant to therapy [8]. Cancer stem cells are also known to secrete factors in response to hypoxia, increasing tumor angiogenesis, and thereby promoting disease progression [9]. In spite of the development mechanism of melanoma, neovessel formation precedes tumor progression.  \nCurrent cancer treatment methods include surgical resection, chemotherapy, photodynamic therapy, immunotherapy, and targeted therapy. Depending on the patient’s health, tumor stage, and location, the therapeutic strategy may consist of single drugs or combined therapies. Due to the development of different resistance mechanisms, the efficacy of various treatments may be decreased. Studies of the genetic profile of melanocytes and the discovery of molecular factors involved in the  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distrib","cbCairg7pBNAv0OM","https://ap.wps.com/l/cbCairg7pBNAv0OM","pdf",2549614,16,"English","# Abstract\n# Introduction\n# Current cancer treatment approaches\n# Targeted therapy and immunotherapy in melanoma\n# Targeting ferroptosis in melanoma\n## Ferroptosis characteristics and role in tumor progression\n## Therapeutic application via inducing ferroptosis","[{\"question\":\"Why is melanoma considered a major health problem despite its relatively low incidence?\",\"answer\":\"Melanoma makes up only about 1% of skin cancers but leads to a high majority of skin cancer deaths due to its aggressive nature and high-risk progression.\"},{\"question\":\"What defines ferroptosis and how does it differ from other forms of cell death?\",\"answer\":\"Ferroptosis is a regulated cell death process distinguished from autophagy, apoptosis, necrosis, and pyroptosis by biochemistry, genetics, and morphology. It occurs mainly through the accumulation of iron and lipid peroxides in cells.\"},{\"question\":\"How can targeting ferroptosis help melanoma therapy?\",\"answer\":\"Studies described in the review indicate that ferroptosis plays a key role in tumor progression. Inducing ferroptosis in melanoma cells can inhibit tumor cell growth and reduce back warding tumorigenesis.\"}]","Targeting ferroptosis in melanoma - cancer therapeutics | PDF",1790247481]