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Together, these links form a regulatory network with translational implications for next-generation anti-tumor precision strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/targeting-dormant-cancer-cells-ferroptosis-asa-precision-therapeutic-strategy/354076/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/targeting-dormant-cancer-cells-ferroptosis-asa-precision-therapeutic-strategy/354076.png","ImageObject",300,407,{"name":42,"@type":43},"วิน","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are dormant cancer cells a major challenge in cancer therapy?","Question",{"text":63,"@type":64},"Dormant cancer cells contribute to recurrence and metastasis and show robust resistance to conventional therapies, making them difficult to eliminate.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What defines ferroptosis as a regulated cell death mechanism?",{"text":68,"@type":64},"Ferroptosis is characterized by intracellular iron accumulation and the induction of lipid peroxidation, enabling cell death through a distinct pathway from apoptosis and necrosis.",{"name":70,"@type":61,"acceptedAnswer":71},"How do oxidative stress, TGF-β signaling, autophagy, and lipid metabolism relate to ferroptosis and dormancy?",{"text":72,"@type":64},"These processes have dual roles in dormant cancer-cell survival and in the progression of ferroptosis, shaping how dormant cells respond to ferroptosis-based interventions.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},354076,1790154553,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","Hao et al. Cellular & Molecular Biology Letters (2026) 31:68 [https://doi.org/10.1186/s11658-026-00895-y](https://doi.org/10.1186/s11658-026-00895-y)  \nCellular & Molecular Biology Letters  \nMINI REVIEW Open Access  \nTargeting dormant cancer cells: ferroptosis asa precision therapeutic strategy  \nSijia Hao1,2, Yulu Guo1,2, Qiaozhen Huang3, Lu Gan1,2, Cheng Chen4, Qiang Li1,2*, Cuixia Di1,2* and Jing Si1,2*  \n*Correspondence: Qiang Li[liqiang@impcas.ac.cn](liqiang@impcas.ac.cn)[ ](liqiang@impcas.ac.cn)Cuixia Di[dicx@impcas.ac.cn](dicx@impcas.ac.cn)[ ](dicx@impcas.ac.cn)Jing Si  \n[sijing@impcas.ac.cn](sijing@impcas.ac.cn)[ ](sijing@impcas.ac.cn)1Department of Medical PhysicsInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China  \n2College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China  \n3School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, China  \n4Department of Breast, Gansu Wuwei Tumour Hospital, Wuwei, China  \nAbstract  \nDormant cancer cells are a significant source of cancer recurrence and metastasis and exhibit robust resistance to conventional therapies. Therefore, the exploration of novel therapeutic strategies to eliminate these cells has become a hot topic in cancer research. Ferroptosis, a newly identified form of regulated cell death, has garnered considerable attention in the field of cancer therapy in recent years. As a novel form of regulated cell death, the core mechanism of ferroptosis lies in the accumulation of intracellular iron and the induction of lipid peroxidation. Oxidative stress, the transforming growth factor-β (TGF-β) signaling pathway, autophagy, and lipid metabolism play dual roles in the survival of dormant cancer cells and the process of ferroptosis, influencing the response of dormant cancer cells to ferroptosis. These complex molecular mechanisms form a regulatory network between ferroptosis and dormant cancer cells, which holds significant implications for the development of future anti-tumor therapeutic strategies. This review synthesizes current evidence on targeting ferroptosis to eliminate dormant cancer cells, positions ferroptosis asa precision modality against dormant cancer cells, and discusses its therapeutic promise as a conceptual framework for developing next-generation anti-tumor strategies.  \nKeywords Cancer dormancy, Ferroptosis, Oxidative stress, TGF-β signaling, Lipid metabolism, Autophagy  \nGraphical abstract  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by-nc-nd/4.0/.  \nHao et al. Cellular & Molecular Biology Letters (2026) 31:68 Page 2 of 26  \nIntroduction  \nGlobal cancer statistics indicate that in 2020 an estimated 19.3 million new cancer cases and nearly 10 million cancer-related deaths occurred worldwide [1]. As time progresses, the likelihood that cancer will become the leading cause of human death is increasing.  \nNevertheless, cancer therapy continues to face numerous challenges, among which the problem ","cbCait7H8jWiPpX1","https://ap.wps.com/l/cbCait7H8jWiPpX1","pdf",1710628,26,"English","# Abstract\n# Introduction\n# The history of discovery and treatment of dormant cancer cells","[{\"question\":\"Why are dormant cancer cells a major challenge in cancer therapy?\",\"answer\":\"Dormant cancer cells contribute to recurrence and metastasis and show robust resistance to conventional therapies, making them difficult to eliminate.\"},{\"question\":\"What defines ferroptosis as a regulated cell death mechanism?\",\"answer\":\"Ferroptosis is characterized by intracellular iron accumulation and the induction of lipid peroxidation, enabling cell death through a distinct pathway from apoptosis and necrosis.\"},{\"question\":\"How do oxidative stress, TGF-β signaling, autophagy, and lipid metabolism relate to ferroptosis and dormancy?\",\"answer\":\"These processes have dual roles in dormant cancer-cell survival and in the progression of ferroptosis, shaping how dormant cells respond to ferroptosis-based interventions.\"}]","Targeting dormant cancer cells: ferroptosis asa precision therapeutic strategy | PDF",1790108767,66]