[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329895-105":59,"doc-detail-329895-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","targeting-colorectal-cancer-at-the-level-of-nuclear-pore-complex-review-article","Targeting colorectal cancer at the level of nuclear pore complex - Review Article","","Nuclear pore complexes (NPCs) are membrane-embedded architectures that control nucleocytoplasmic trafficking of proteins and RNAs, which is essential for normal cellular function. Altered NPC structure and activity, driven by dysregulated nucleoporins and karyopherins, reshape signaling networks in cancers, including colorectal cancer (CRC). The review analyzes evidence from 1990–2023 on NPC-related mechanisms, therapeutic implications, and the potential of karyopherin-targeting inhibitors to regulate aberrant cargo transport.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-colorectal-cancer-at-the-level-of-nuclear-pore-complex-review-article/329895/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-colorectal-cancer-at-the-level-of-nuclear-pore-complex-review-article/329895.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role do nuclear pore complexes play in cells?","Question",{"text":112,"@type":113},"Nuclear pore complexes regulate nucleocytoplasmic transportation of key materials such as proteins and RNAs, supporting proper cellular functionality.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is colorectal cancer linked to the nuclear pore complex?",{"text":117,"@type":113},"Variations and altered expression of nucleoporins and karyopherins can change cellular pathways and signaling networks that contribute to colorectal cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategy does the review highlight for colorectal cancer?",{"text":121,"@type":113},"Targeting karyopherins with inhibitors is discussed as a way to regulate altered karyopherin levels and potentially influence colorectal cancer-associated 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[homepage: www. elsevier. com/locate/jare](homepage: www. elsevier. com/locate/jare)  \nReview Article  \nTargeting colorectal cancer at the level of nuclear pore complex Muhammad Mahtab Aslam Khan Khakwani a,b, 1, Xin-Ying Ji c,d, 1, Saadullah Khattak a, Ying-Chuan Sun e, Kunhou Yao b, ⇑, Lei Zhang a,b, ⇑  \na Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medicine, Henan University, Kaifeng, Henan 475004, China b Department of General Surgery, Huaihe Hospital of Henan University, Henan University, Kaifeng 475004, China  \nc Department of Oncology, Huaxian County Hospital, Huaxian, Henan Province 456400, China  \nd Faculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Gong-Ming Rd, Mazhai Town, Erqi District, Zhengzhou, Henan 450064, China e Department of Internal Oncology (Section I), Xuchang Municipal Central Hospital, Xuchang, Henan 430000, China  \nh i g h l i g h t s  \n􀀁 A detailed architecture of nuclear pore complex (NPC) provides the basis for understanding the mechanism of diseases like cancers at NPC.  \n􀀁 Variations in different building block nucleoporins of NPC, result in altered cellular pathways associated with colorectal cancer.  \n􀀁 Dysregulation of nucleocytoplasmic transport via NPC by defected karyopherins, contributes to a number of disorders including colorectal cancer.  \n􀀁 Inhibitors of karyopherins at present have potential to regulate the altered level/expression of these karyopherin molecules.  \n􀀁 Development of novel and more effective karyopherin inhibitors may provide more effective therapeutic strategies for colorectal cancer.  \ng r a p h i c a l a b s t r a c t  \na r t i c l e i n f o  \nArticle history:  \nReceived 13 March 2024 Revised 23 May 2024  \na b s t r a c t  \nBackground: Nuclear pore complexes (NPCs) are the architectures entrenched in nuclear envelop of a cell that regulate the nucleo-cytoplasmic transportation of materials, such as proteins and RNAs for proper  \nAbbreviations: NPC, Nuclear pore complex; CRC, Colorectal cancer; Nups, Nucleoporins; GWAS, genome-wide association studies; KPNs, Karyopherins; EXP, Exportin; IMP, Importin; BATF2, Basic Leucine Zipper ATF-Like Transcription Factor 2; NLS, Nuclear localization signal; NES, Nuclear export signal; cNLS, Classical nuclear localization signal; ORI, Oridonin; RCC1, Regulator of chromosome condensation 1; lncRNA, Long non-coding RNA; miRNA, MicroRNA; siRNA, Small interfering RNA; SIRT1, sirtuin 1; CENPA, Centromere protein A; Wip1, Wild-type p53-induced phosphatase 1; BRCA1, Breast cancer type 1; AKT, Serine-threonine kinase; CSE1L, Chromosome segregation 1 like; TNPO, Transportin; FG, phenylalanine-glycine; HS-AFM, High-speed atomic force microscopy; CEACAM5, Carcinoembryonic antigen-related cell adhesion molecule 5; TPR, Translocated promoter region; SRCAP, SNF2-Related CBP Activator Protein; STAT3, Signal transducer and activator of transcription 3; GSK3b, Glycogen synthase kinase-3 beta; TCF-4, T-cell factor 4; NXF1, Nuclear RNA export factor 1; HOXA, Homeobox-A; TGF-b, Transforming growth factor beta; HOTTIP, HOXA distal transcript antisense RNA; DLEU1, Deleted in lymphocytic leukemia 1; SMARCA1, SWI/SNF Related, matrix associated, actin dependent regulator of chromatin, subfamily A 1; BRD-4, Bromodomain containing-4; DEPDC1B, DEP domain protein 1B; Wnt, Wingless related integration site; NF-jB, Nuclear factor kappa B; RAE1, Ribonucleic acid export 1.  \n⇑ Corresponding authors at: Department of General Surgery, Huaihe Hospital of Henan University, Henan University, Kaifeng 475004, China; School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.  \nE-mail addresses: [zhlei@henu.edu.cn](zhlei@henu.edu.cn) (L. Zhang), [yaokunhou@126.com](yaokunhou@126.com) (K. Yao).  \n1 These authors contributed equally to this work.  \n[https://d","cbCaitg8IPUiIaOJ","https://ap.wps.com/l/cbCaitg8IPUiIaOJ","pdf",4765666,22,"English","# Abstract\n## Background and significance\n## Review aim and scope\n## Therapeutic implications","[{\"question\":\"What role do nuclear pore complexes play in cells?\",\"answer\":\"Nuclear pore complexes regulate nucleocytoplasmic transportation of key materials such as proteins and RNAs, supporting proper cellular functionality.\"},{\"question\":\"How is colorectal cancer linked to the nuclear pore complex?\",\"answer\":\"Variations and altered expression of nucleoporins and karyopherins can change cellular pathways and signaling networks that contribute to colorectal cancer.\"},{\"question\":\"What therapeutic strategy does the review highlight for colorectal cancer?\",\"answer\":\"Targeting karyopherins with inhibitors is discussed as a way to regulate altered karyopherin levels and potentially influence colorectal cancer-associated mechanisms.\"}]","Targeting colorectal cancer at the level of nuclear pore complex - Review Article | PDF",1789986059,55]