[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332702-105":59,"doc-detail-332702-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","targeting-catalase-in-cancer-review","Targeting catalase in cancer - Review","","Healthy cells rely on a coordinated antioxidant network to avoid toxic reactive oxygen species (ROS) buildup triggered by environmental stress. Cancer cells frequently show elevated ROS and disrupted antioxidant balance, with catalase often reduced. Because catalase detoxifies hydrogen peroxide while influencing numerous redox-linked cellular pathways, it becomes central to controlling proliferation, metabolic rewiring, immune escape, and metastasis. This review summarizes the past decade’s progress and remaining challenges, including catalase regulation, subcellular localization, microbial catalases, and catalase-based therapeutic strategies with their advantages and limitations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-catalase-in-cancer-review/332702/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-catalase-in-cancer-review/332702.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is catalase important in cancer biology?","Question",{"text":112,"@type":113},"Catalase helps manage oxidative stress by detoxifying hydrogen peroxide. Its altered expression and activity in cancer cells influence ROS-dependent processes linked to proliferation, immune escape, and metastasis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does ROS relate to tumor progression in the reviewed context?",{"text":117,"@type":113},"The review states that cancer cells often have higher ROS levels and altered antioxidant molecule levels, which supports proliferative advantages and drives metabolic reprogramming, immune escape, and metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"What topics does the review cover about catalase?",{"text":121,"@type":113},"It discusses regulation of catalase expression, subcellular localization, potential roles of microbial catalases in tumor environments, and summarizes catalase-based therapies and their pros, cons, and limitations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332702,1790997883,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Redox Biology 77 (2024) 103404  \nContents lists available at ScienceDirect  \nRedox Biology  \njournal [homepage:](homepage: www.elsevier.com/locate/redox)[ www.elsevier.com/locate/redox](homepage: www.elsevier.com/locate/redox)  \n| Targeting catalase in cancer\u003Cbr>Christophe Glorieux a,*, Pedro Buc Calderon b,c,d,**\u003Cbr>a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 510060, Guangzhou, China\u003Cbr>b Química y Farmacia, Facultad de Ciencias de La Salud, Universidad Arturo Prat, 1100000, Iquique, Chile\u003Cbr>c Instituto de Química Medicinal, Universidad Arturo Prat, 1100000, Iquique, Chile\u003Cbr>d Research Group in Metabolism and Nutrition, Louvain Drug Research Institute, Universit´e Catholique de Louvain, 1200, Brussels, Belgium |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords: Catalase\u003Cbr>Cancer\u003Cbr>Regulation Subcellular localization Tumor environment Catalase-based therapy |  | Healthy cells have developed a sophisticated network of antioxidant molecules to prevent the toxic accumulation of reactive oxygen species (ROS) generated by diverse environmental stresses. On the opposite, cancer cells often exhibit high levels of ROS and an altered levels of antioxidant molecules compared to normal cells. Among them, the antioxidant enzyme catalase plays an essential role in cell defense against oxidative stress through the dismutation of hydrogen peroxide into water and molecular oxygen, and its expression is often decreased in cancer cells. The elevation of ROS in cancer cells provides them proliferative advantages, and leads to metabolic reprogramming, immune escape and metastasis. In this context, catalase is of critical importance to control these cellular processes in cancer through various mechanisms. In this review, we will discuss the major progresses and challenges in understanding the role of catalase in cancer for this last decade. This review also aims to provide important updates regarding the regulation of catalase expression, subcellular localization and discuss about the potential role of microbial catalases in tumor environment. Finally, we will describe the different catalase-based therapies and address the advantages, disadvantages, and limitations associated with modulating catalase therapeutically in cancer treatment. |\n\n1. Introduction  \nThe discovery of catalase (Enzyme commission number: EC [1.11.1.6](1.11.1.6)) can be traced back to the early 19th century when the French chemist Louis-Jacques Th´enard discovered hydrogen peroxide (H2O2) [1]. In 1900, Oscar Loew proposed the name ‘catalase’ for the substance capable to detoxify H2O2 and found in many organisms ranging from plants to mammals [2]. Later, the works of the Nobel prize laureates Otto Warburg, James Sumner, Christian de Duve, and studies of eminent scientists such as Britton Chance and Helmut Sies provided further insights into the mechanisms of catalase enzyme activity, its structure, subcellular localization and function [3–7]. The mammalian catalases predominantly exert a catalatic activity through the dismutation of H2O2 into water and molecular oxygen (Enzymatic reaction: 2H2O2 → 2H2O + O2). In addition, catalase can decompose peroxynitrite (ONOO¡ ) [8], oxidize nitric oxide to nitrogen dioxide [9], metabolize reactive sulfide species [10], exhibit a marginal peroxidase [11] and low oxidase activity [12]. The human catalase enzyme consists of four identical  \nsubunits of 62 kDa, each subunit containing four distinct domains, a NADPH binding site and one prosthetic heme group [13]. Catalase is a powerful and extremely efficient enzyme with the highest turnover number (k cat), defined as the maximal number of molecules of substrate converted to product per active site per unit of time, of all enzymes found in living beings [14]. This antioxidant enzyme possesses the ability to metabolize tens of millions molecules of H2O2 per s","cbCaicM1hRdLcmbU","https://ap.wps.com/l/cbCaicM1hRdLcmbU","pdf",3464935,16,"English","# Introduction\n## Catalase discovery and biochemical properties\n## Catalase structure and cellular role\n## Catalase regulation in healthy vs cancer cells\n# Article focus and aims","[{\"question\":\"Why is catalase important in cancer biology?\",\"answer\":\"Catalase helps manage oxidative stress by detoxifying hydrogen peroxide. Its altered expression and activity in cancer cells influence ROS-dependent processes linked to proliferation, immune escape, and metastasis.\"},{\"question\":\"How does ROS relate to tumor progression in the reviewed context?\",\"answer\":\"The review states that cancer cells often have higher ROS levels and altered antioxidant molecule levels, which supports proliferative advantages and drives metabolic reprogramming, immune escape, and metastasis.\"},{\"question\":\"What topics does the review cover about catalase?\",\"answer\":\"It discusses regulation of catalase expression, subcellular localization, potential roles of microbial catalases in tumor environments, and summarizes catalase-based therapies and their pros, cons, and limitations.\"}]","Targeting catalase in cancer - Review | PDF",1789999129]