[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-337713-105":59,"doc-detail-337713-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","targeting-acat1-in-cancer-from-threat-to-treatment","Targeting ACAT1 in cancer: from threat to treatment","","Altered cholesterol metabolism is identified as a critical feature of cancers. Cholesterol is essential for membrane integrity and signaling, yet intracellular cholesterol is tightly regulated through transport and conversion into cholesteryl esters by acyl-CoA:cholesterol acyltransferases (ACATs). Although ACAT2 shows limited relevance in tumors, ACAT1 is widely implicated in tumor initiation and progression and is also essential for regulating anti-tumor immunity, suggesting ACAT1 inhibition as a strategy to enhance immune responses and eliminate tumors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/targeting-acat1-in-cancer-from-threat-to-treatment/337713/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/targeting-acat1-in-cancer-from-threat-to-treatment/337713.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is targeting ACAT1 considered relevant in cancer?","Question",{"text":112,"@type":113},"ACAT1 is widely involved in tumor initiation and progression. It also plays a key role in regulating anti-tumor immunity through its function in cholesterol metabolism.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does cholesterol play in cancer biology according to the text?",{"text":117,"@type":113},"Cholesterol maintains cell membrane integrity and supports signaling transduction for cell survival. Tumor cells rely on cholesterol for membrane biogenesis and multiple biological processes.",{"name":119,"@type":110,"acceptedAnswer":120},"How do ACAT1 and ACAT2 relate to cholesterol ester formation?",{"text":121,"@type":113},"ACATs convert cholesterol into less toxic cholesteryl esters. The text notes that ACAT1 is implicated in tumors, while ACAT2 has limited value in tumors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},337713,1790787012,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TYPE Mini Review  \nPUBLISHED 24 April 2024  \nDOI 10.3389/fonc.2024.1395192  \nOPEN ACCESS  \nEDITED BY  \nParmanand Malvi,  \nUniversity of Alabama at Birmingham, United States  \nREVIEWED BY  \nChunming Cheng,  \nUniversity of Oklahoma, United States Elena Sacco,  \nUniversity of Milano-Bicocca, Italy Uri Nir,  \nBar-Ilan University, Israel  \n*CORRESPONDENCE Xuan Xiao  \n [brex@sina.com](brex@sina.com)  \nRECEIVED 03 March 2024  \nACCEPTED 12 April 2024  \nPUBLISHED 24 April 2024  \nCITATION  \nSun T and Xiao X (2024) Targeting ACAT1 in cancer: from threat to treatment.  \nFront. Oncol. 14:1395192 .  \ndoi: 10.3389/fonc.2024.1395192  \nCOPYRIGHT  \n© 2024 Sun and Xiao. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) .  \nThe use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nTargeting ACAT1 in cancer: from threat to treatment  \nTie Sun and Xuan Xiao*  \nDepartment of Thyroid and Breast Surgery, People’s Hospital of China Medical University (Liaoning Provincial People’s Hospital), Shenyang, China  \nAltered cholesterol metabolism has been identified as a critical feature of cancers. Cholesterol functions as the main component of cell membrane, cholesterol and is required for sustaining membrane integrity and mediating signaling transduction for cell survival. The intracellular level of cholesterol is dynamically regulated. Excessive cholesterol could be converted to less toxic cholesteryl esters by acyl-coenzyme A:cholesterol acyltransferases (ACATs) . While ACAT2 has limited value in cancers, ACAT1 has been found to be widely participated in tumor initiation and progression. Moreover, due to the important role of cholesterol metabolism in immune function, ACAT1 is also essential for regulating anti-tumor immunity. ACAT1 inhibition may be exploited as a potential strategy to enhance the anti-tumor immunity and eliminate tumors. Herein, a comprehensive understanding of the role of ACAT1 in tumor development and anti-tumor immunity may provide new insights for anti-tumor strategies.  \nKEYWORDS  \nmetabolism, immunity, ACAT (acyl-CoA:cholesterol acyltransferase), cancer, cholesterol  \nIntroduction  \nA hallmark of cancer is the deregulated metabolism (1) . As an integral component of cell membrane, cholesterol is crucial for maintaining membrane integrity and signaling transduction for cell survival (2) . Besides, cholesterol also participates in the regulation of multiple biological processes, including lipid metabolism, inflammation, apoptosis, and cell survival (3–5) . Cholesterol-derived metabolites exert a wide variety of biological effects in tumor development and anti-tumor immunity responses (6) . As fast-proliferating cells, tumor cells rely on cholesterol for membrane biogenesis and various biological processes  \n(7) . Therefore, targeting cholesterol metabolism may provide novel therapeutic strategies for cancer management.  \nIntracellular cholesterol is dynamically transported for maintaining membrane integrity (8) . Excessive cholesterol is either exported by ATP-binding cassette proteins, or converted to less toxic cholesteryl esters by acyl-coenzyme A: cholesterol acyltransferases (ACATs) to store in the form of lipid droplets or lipoproteins (3) . ACATs belong to membrane-bound O-acyltransferase family, are composed of two enzymes localizing in the mitochondria and cytoplasm, respectively (9) . ACAT1 and ACAT2 catalyze acyl transfer from acyl-coenzyme A (CoA) to cholesterol and produce cholesterol esters that are used for  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nstorage and intercellular transport of sterol, which is important for cellular cholesterol homeostasis (10) . ACAT","cbCaio1BLxsqQf8Z","https://ap.wps.com/l/cbCaio1BLxsqQf8Z","pdf",1403549,"English","# Introduction\n## ACAT1 structure, regulation, and function","[{\"question\":\"Why is targeting ACAT1 considered relevant in cancer?\",\"answer\":\"ACAT1 is widely involved in tumor initiation and progression. It also plays a key role in regulating anti-tumor immunity through its function in cholesterol metabolism.\"},{\"question\":\"What role does cholesterol play in cancer biology according to the text?\",\"answer\":\"Cholesterol maintains cell membrane integrity and supports signaling transduction for cell survival. Tumor cells rely on cholesterol for membrane biogenesis and multiple biological processes.\"},{\"question\":\"How do ACAT1 and ACAT2 relate to cholesterol ester formation?\",\"answer\":\"ACATs convert cholesterol into less toxic cholesteryl esters. The text notes that ACAT1 is implicated in tumors, while ACAT2 has limited value in tumors.\"}]","Targeting ACAT1 in cancer: from threat to treatment | PDF",1790020293,18]