[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380221-105":59,"doc-detail-380221-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","systemic-photoprotection-in-melanoma-and-non-melanoma-skin-cancer","Systemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer","","Non-melanoma skin cancers (NMSCs)—including basal cell carcinoma, squamous cell carcinoma, and actinic keratosis—are the most common malignancies and become severe when diagnosis and treatment are delayed or inadequate. Malignant melanoma is less frequent but more deadly. Because skin cancers impose both individual and societal burdens, prevention is essential, with ultraviolet exposure being a key risk factor. The review focuses on topical and systemic photoprotection, especially orally administered molecules that protect through antioxidant, anti-inflammatory, or immunomodulator mechanisms, and summarizes clinical and preclinical evidence for systemic agents.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/systemic-photoprotection-in-melanoma-and-non-melanoma-skin-cancer/380221/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/systemic-photoprotection-in-melanoma-and-non-melanoma-skin-cancer/380221.png","ImageObject",300,407,{"name":92,"@type":93},"Sophia Brooks","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What are NMSCs and which diseases are included in this group?","Question",{"text":113,"@type":114},"NMSCs include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and actinic keratosis (AK). They are the most common skin cancers.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is photoprotection considered a key prevention strategy?",{"text":118,"@type":114},"Ultraviolet (UV) ray exposure is identified as a main risk factor for skin cancer. The review states that photoprotection can be topical or systemic and aims to prevent UV-related damage.",{"name":120,"@type":111,"acceptedAnswer":121},"How does systemic photoprotection work and what kinds of molecules are discussed?",{"text":122,"@type":114},"Systemic photoprotection consists of oral molecules that protect human skin against UV damage via antioxidant, anti-inflammatory, or immunomodulator mechanisms. The review summarizes clinical and preclinical data on commonly used systemic compounds.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},380221,1790472378,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","biomolecules  \nReview  \nSystemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer  \nMariafrancesca Hyeraci 1,2,*, Elena Sofia Papanikolau 1, Marta Grimaldi 3, Francesco Ricci 1, Sabatino Pallotta 1, Rosanna Monetta 1, Ylenia Aura Minafá 1, Giovanni Di Lella 1, Giovanna Galdo 4, Damiano Abeni 1, Luca Fania 1 and Elena Dellambra 1  \nCitation: Hyeraci, M.; Papanikolau, E.S.; Grimaldi, M.; Ricci, F.; Pallotta, S.; Monetta, R.; Minafò, Y.A.; Di Lella, G.; Galdo, G.; Abeni, D.; et al. Systemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer. Biomolecules 2023, 13, 1067 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)biom13071067  \nAcademic Editors: Dietrich Büsselberg, Samson Mathews Samuel and Peter Kubatka  \nReceived: 13 June 2023  \nRevised: 29 June 2023  \nAccepted: 30 June 2023  \nPublished: 2 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 IDI-IRCCS, Dermatological Research Hospital, Via dei Monti di Creta 104, 00167 Rome, Italy;  \n[es.papanikolaou@gmail.com](es.papanikolaou@gmail.com) (E.S.P.); [f.ricci@idi.it](f.ricci@idi.it) (F.R.); [s.pallotta@idi.it](s.pallotta@idi.it) (S.P.);  \n[ros.monetta88@gmail.com](ros.monetta88@gmail.com) (R.M.); [y.minafo@idi.it](y.minafo@idi.it) (Y.A.M.); [g.dilella@idi.it](g.dilella@idi.it) (G.D.L.); [d.abeni@idi.it](d.abeni@idi.it) (D.A.);  \n[l.fania@idi.it](l.fania@idi.it) (L.F.); [e.dellambra@idi.it](e.dellambra@idi.it) (E.D.)  \n2 Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy  \n3 Department of Medical and Surgical Sciences, Division of Dermatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy; [martagrimaldi64@gmail.com](martagrimaldi64@gmail.com)  \n4 Dermatology Unit, AORN San Giuseppe Moscati, 83100 Avellino, Italy; giovannagaldo@libero.it  \n* [Correspondence: mariafrancesca.hyeraci@gmail.com](Correspondence: mariafrancesca.hyeraci@gmail.com)  \nAbstract: Non-melanoma skin cancers (NMSCs), which include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and actinic keratosis (AK), are the most common cancer diseases in the Caucasian race. If diagnosed late and improperly treated, BCC and SCC can become locally advanced and metastasize. Malignant melanoma (MM) is less frequent but more lethal than NMSC. Given the individual and social burdens of skin cancers, performing an adequate prevention is needed. Ultraviolet (UV) ray exposure is one of the main risk factors for skin cancer. Thus, the first-choice prevention strategy is represented by photoprotection that can be both topical and systemic. The latter consists of the oral administration of molecules which protect human skin against the damaging effects of UV rays, acting through antioxidant, anti-inflammatory, or immunomodulator mechanisms. Although several compounds are commonly used for photoprotection, only a few molecules have demonstrated their effectiveness in clinical trials and have been included in international guidelines for NMSC prevention (i.e., nicotinamide and retinoids) . Moreover, none of them have been demonstrated as able to prevent MM. Clinical and preclinical data regarding the most common compounds used for systemic photoprotection are reported in this review, with a focus on the main mechanisms involved in their photoprotective properties.  \nKeywords: photoprotection; melanoma; non-melanoma; basal cell carcinoma; squamous cell carcinoma  \n1. Introduction  \nNon-melanoma skin cancers (NMSCs) account for approximately 20% of all malignancies and their incidence is steadily increasing [1,2] . These tumors consist of basal cell ","cbCaibgXXEy53eZp","https://ap.wps.com/l/cbCaibgXXEy53eZp","pdf",1970208,14,"English","# Introduction\n## Non-melanoma skin cancers (NMSCs) epidemiology and clinical features\n## Malignant melanoma (MM) classification and mortality impact\n## Ultraviolet (UV) exposure as a primary cause and prevention rationale","[{\"question\":\"What are NMSCs and which diseases are included in this group?\",\"answer\":\"NMSCs include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and actinic keratosis (AK). They are the most common skin cancers.\"},{\"question\":\"Why is photoprotection considered a key prevention strategy?\",\"answer\":\"Ultraviolet (UV) ray exposure is identified as a main risk factor for skin cancer. The review states that photoprotection can be topical or systemic and aims to prevent UV-related damage.\"},{\"question\":\"How does systemic photoprotection work and what kinds of molecules are discussed?\",\"answer\":\"Systemic photoprotection consists of oral molecules that protect human skin against UV damage via antioxidant, anti-inflammatory, or immunomodulator mechanisms. The review summarizes clinical and preclinical data on commonly used systemic compounds.\"}]","Systemic Photoprotection in Melanoma and Non-Melanoma Skin Cancer | PDF",1790239269,35]