[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426294-105":59,"doc-detail-426294-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","systemic-inflammation-and-its-interaction-with-alzheimers-disease-pathology-in-accelerating-cognitive-decline","Systemic Inflammation and Its Interaction with Alzheimer’s Disease Pathology in Accelerating Cognitive Decline","","Systemic inflammation may accelerate cognitive decline linked to Alzheimer’s disease, but mechanisms remain uncertain. This study tested associations between blood systemic inflammatory markers and longitudinal cognitive decline and examined interactions with AD pathology markers (amyloid, tau) and neuroinflammation (GFAP). Using 161 BIOCARD participants, baseline and change measures were analyzed with linear mixed-effects models, controlling for age, sex, education, and vascular risk. Inflammation alone showed no direct effect, while significant interactions indicated accelerated decline when systemic inflammation co-occurred with amyloid/tau or GFAP, suggesting a synergistic risk model to support targeted intervention.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/systemic-inflammation-and-its-interaction-with-alzheimers-disease-pathology-in-accelerating-cognitive-decline/426294/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/systemic-inflammation-and-its-interaction-with-alzheimers-disease-pathology-in-accelerating-cognitive-decline/426294.png","ImageObject",300,407,{"name":92,"@type":93},"Grenda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-05","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Does systemic inflammation alone predict faster cognitive decline in Alzheimer’s disease?","Question",{"text":112,"@type":113},"No. Systemic inflammatory markers were not associated with faster cognitive decline on their own.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which interactions showed steeper cognitive decline?",{"text":117,"@type":113},"Faster decline occurred when systemic inflammation co-occurred with AD pathology or neuroinflammation. Examples include CRP×Aβ42/40 and TNFR1×ptau181, as well as IL1β×GFAP (CSF-based) and CRP×Aβ42/40 and TNFR1×GFAP (blood-based).",{"name":119,"@type":110,"acceptedAnswer":120},"What does the study conclude about the role of systemic inflammation?",{"text":121,"@type":113},"Systemic inflammation does not act independently; it amplifies adverse effects of amyloid, tau, and GFAP, supporting a synergistic model and potentially helping identify individuals at elevated risk for targeted intervention.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426294,1790794690,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},7971474921005,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","1288 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.4294  \nSYSTEMIC INFLAMMATION AND ITS INTERACTION  \nWITH ALZHEIMER’S DISEASE PATHOLOGY IN  \nACCELERATING COGNITIVE DECLINE  \nDiefei Chen1, Keenan Walker2, Marilyn Albert3,  \nJeremy Walston3, Jacqueline Langdon3, and Alden Gross1, 1. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States, 2. National Institute on Aging, Baltimore, Maryland, United States, 3. Johns Hopkins School of Medicine, Baltimore, Maryland, United States  \nSystemic inflammation may accelerate cognitive decline related to Alzheimer’s disease (AD), yet underlying mechanisms remain unclear. We tested whether systemic inflammatory markers are associated with cognitive decline and whether they interact with AD pathology (amyloid, tau) and neuroinflammation (GFAP) to accelerate cognitive decline. We analyzed  \n161 participants from the BIOCARD study, who were cognitively unimpaired at baseline, with the first biofluid collection at mean age of 59.3 years (SD = 6.2), median of 3 samples (range 2–5) over 19.5 years on average. Blood-based systemic inflammatory markers were: IL1β, IL6, IL8, TNFα, TNFR1, CRP. Baseline Aβ42/40, ptau181, and GFAP were assayed in both CSF and blood. Linear mixedeffects models related (1) baseline systemic inflammatory levels,(2) withinperson change in each systemic inflammatory marker, and (3) interactions between baseline systemic inflammation and Aβ, ptau181, or GFAP to change in a general cognitive factor score, adjusting for age, sex, education, and vascular risk. Systemic inflammatory markers alone were not associated with faster cognitive decline. However, significant interactions indicated steeper cognitive decline when systemic inflammation cooccurred with AD pathology or neuroinflammation. Using CSF markers, faster decline was seen for CRP×Aβ42/40, TNFR1×ptau181, and IL1β×GFAP. Using blood-based markers, similar patterns emerged for CRP×Aβ42/40; IL8, TNFα, TNFR1×ptau181; IL8, TNFR1×GFAP. Systemic inflammation did not predict cognitive decline on its own but amplified the adverse effects of amyloid, tau, and GFAP. These findings support a synergistic model in which systemic inflammation interacts with AD pathophysiology to accelerate cognitive decline and may aid in identifying individuals at elevated risk for targeted intervention.","cbCaitoyKp1t75Ps","https://ap.wps.com/l/cbCaitoyKp1t75Ps","pdf",1136345,"English","# Background and Objective\n## Study Design and Cohort\n## Inflammatory and Pathology Markers\n## Statistical Modeling Approach\n## Key Findings and Implications","[{\"question\":\"Does systemic inflammation alone predict faster cognitive decline in Alzheimer’s disease?\",\"answer\":\"No. Systemic inflammatory markers were not associated with faster cognitive decline on their own.\"},{\"question\":\"Which interactions showed steeper cognitive decline?\",\"answer\":\"Faster decline occurred when systemic inflammation co-occurred with AD pathology or neuroinflammation. Examples include CRP×Aβ42/40 and TNFR1×ptau181, as well as IL1β×GFAP (CSF-based) and CRP×Aβ42/40 and TNFR1×GFAP (blood-based).\"},{\"question\":\"What does the study conclude about the role of systemic inflammation?\",\"answer\":\"Systemic inflammation does not act independently; it amplifies adverse effects of amyloid, tau, and GFAP, supporting a synergistic model and potentially helping identify individuals at elevated risk for targeted intervention.\"}]","Systemic Inflammation and Its Interaction with Alzheimer’s Disease Pathology in Accelerating Cognitive Decline | PDF",1790640123]