[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378445-105":59,"doc-detail-378445-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","synthetic-receptors-for-early-detection-and-treatment-of-cancer","Synthetic Receptors for Early Detection and Treatment of Cancer","","Over recent decades, synthetic macrocyclic compounds have attracted scientific interest for their ability to selectively and reversibly form complexes with diverse guest molecules. This review surveys major macrocycles, including cyclodextrins, calixarenes, calixresorcinarenes, pillarenes, and cucurbiturils, highlighting their complexation, sensing performance, and relevance to cancer detection. It also addresses how reversible encapsulation can enhance anticancer drug solubility, stability, and in vivo delivery, and discusses potential applications for detecting environmental carcinogens and related cleanup.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/synthetic-receptors-for-early-detection-and-treatment-of-cancer/378445/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/synthetic-receptors-for-early-detection-and-treatment-of-cancer/378445.png","ImageObject",300,407,{"name":92,"@type":93},"Kurz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are synthetic macrocyclic receptors and why are they important for cancer detection?","Question",{"text":112,"@type":113},"They are macrocyclic compounds that can selectively and reversibly form complexes with target molecules. Their binding ability enables sensitive detection and quantification of cancer-related guests and can target cancer cell surfaces or marker compounds.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which macrocyclic families are covered in the review?",{"text":117,"@type":113},"The review summarizes common synthetic macrocyclic compounds, including cyclodextrins, calixarenes, calixresorcinarenes, pillarenes, and cucurbiturils. It links these families to their complexation behavior and relevance to cancer applications.",{"name":119,"@type":110,"acceptedAnswer":120},"How can macrocyclic encapsulation improve anticancer therapy?",{"text":121,"@type":113},"Many anticancer drugs face limitations such as low solubility, instability in vivo, and poor transport to required sites. Reversible encapsulation in macrocyclic carriers can improve solubility, stability, and transport, supporting controlled release for therapeutic effect.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378445,1791172589,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","biosensors  \nReview  \nSynthetic Receptors for Early Detection and Treatment of Cancer  \nFrank Davis  and S²amus P. J. Higson *  \nCitation: Davis, F.; Higson, S.P.J. Synthetic Receptors for Early Detection and Treatment of Cancer. Biosensors 2023, 13, 953. [https://](https://)[ ](https://)[doi.org/10.3390/bios13110953](doi.org/10.3390/bios13110953)  \nReceived: 5 September 2023  \nRevised: 10 October 2023  \nAccepted: 22 October 2023  \nPublished: 25 October 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK; [fd417@cam.ac.uk](fd417@cam.ac.uk)  \n* Correspondence: [sh2124@cam.ac.uk](sh2124@cam.ac.uk)  \nAbstract: Over recent decades, synthetic macrocyclic compounds have attracted interest from thescientific community due to their ability to selectively and reversibly form complexes with a huge variety of guest moieties. These molecules have been studied within a wide range of sensing and other fields. Within this review, we will give an overview of the most common synthetic macrocyclic compounds including cyclodextrins, calixarenes, calixresorcinarenes, pillarenes and cucurbiturils. These species all display the ability to form a wide range of complexes. This makes these compounds suitable in the field of cancer detection since they can bind to either cancer cell surfaces or indeed to marker compounds for a wide variety of cancers. The formation of such complexes allows sensitive and selective detection and quantification of such guests. Many of these compounds also show potential for the detection and encapsulation of environmental carcinogens. Furthermore, many anticancer drugs, although effective in in vitro tests, are not suitable for use directly for cancer treatment due to low solubility, inherent instability in in vivo environments or an inability to be adsorbed by or transported to the required sites for treatment. The reversible encapsulation of these species in amacrocyclic compound can greatly improve their solubility, stability and transport to required sites where they can be released for maximum therapeutic effect. Within this review, we intend to present the use of these species both in cancer sensing and treatment. The various macrocyclic compound families will be described, along with brief descriptions of their synthesis and properties, with an outline of their use in cancer detection and usage as therapeutic agents. Their use in the sensing of environmental carcinogens as well as their potential utilisation in the clean-up of some of these species will also be discussed.  \nKeywords: cancer; early diagnosis of cancer; synthetic receptors for early detection of cancer; synthetic receptors for treatment of cancer; calixarene; cyclodextrin; cucurbituril  \n1. Introduction  \nCancer is one of the world's most serious diseases, leading to chronic illness for millions of people worldwide every year and in 2020 more than 10 million deaths [1] . Mitigating this situation requires both early detection of cancer before it is too late for treatment and after detection through, for example, a combination of surgical, radiological and chemotherapy procedures to cure, treat or manage the condition. Detection and determination of cancer is the first crucial step for curing any patient. A wide number of methods have been used to detect cancer; some of these involve physical-based techniques such as MRI and other scanning methods, while others rely on the selective determination of marker compounds produced by the cancer. Examples of such techniques include prostate-specific antigen, high levels of which can","cbCaij1DuxeDXpIX","https://ap.wps.com/l/cbCaij1DuxeDXpIX","pdf",2637451,27,"English","# Introduction\n# Cancer detection methods\n# Artificial systems for cancer detection\n# Macrocyclic receptors in cancer sensing and treatment\n# Drug delivery challenges and macrocyclic encapsulation","[{\"question\":\"What are synthetic macrocyclic receptors and why are they important for cancer detection?\",\"answer\":\"They are macrocyclic compounds that can selectively and reversibly form complexes with target molecules. Their binding ability enables sensitive detection and quantification of cancer-related guests and can target cancer cell surfaces or marker compounds.\"},{\"question\":\"Which macrocyclic families are covered in the review?\",\"answer\":\"The review summarizes common synthetic macrocyclic compounds, including cyclodextrins, calixarenes, calixresorcinarenes, pillarenes, and cucurbiturils. It links these families to their complexation behavior and relevance to cancer applications.\"},{\"question\":\"How can macrocyclic encapsulation improve anticancer therapy?\",\"answer\":\"Many anticancer drugs face limitations such as low solubility, instability in vivo, and poor transport to required sites. Reversible encapsulation in macrocyclic carriers can improve solubility, stability, and transport, supporting controlled release for therapeutic effect.\"}]","Synthetic Receptors for Early Detection and Treatment of Cancer | PDF",1790230118,68]